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A &R: Effect of Atorvastatin on Knee Cartilage Volume in Patients with Symptomatic Knee Osteoarthritis: Results of Randomized Placebo Controlled Trials

 Last Update: 2021-12-25
 Source: Internet
 Author: User

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Purpose : To determine whether atorvastatin can reduce tibial cartilage volume loss in patients with symptomatic knee osteoarthritis (OA) in a multicenter, randomized, double-blind, placebo-controlled trial .

ObjectiveObjective : In a multicenter, randomized, double-blind, placebo-controlled trial to determine whether statins atorvastatin can slow symptomatic knee osteoarthritis (OA) of the tibial cartilage volume loss of the patient
.

Methods : Participants aged 40-70 were randomized to receive oral atorvastatin ( 40 mg once a day) ( n = 151 ) or matching placebo ( n = 153 )
.

The primary endpoint was the annual percentage change in tibial cartilage volume within 2 years, which was assessed using magnetic resonance imaging (MRI) .
The preset secondary endpoints are the progression of cartilage defects and bone marrow lesions within 2 years .

MethodsMethods : 40-70 year-old participants were randomized to receive oral atorvastatin ( 40 mg , once daily) ( the n-= 151 ) or matching placebo ( the n-= 153 )

Resultsresults : 304 participants in a total of 248 people (81.

ConclusionConclusion : Compared with placebo, oral atorvastatin (once daily 40 mg ) treatment did not significantly reduce the symptoms of knee OA patients 2 cartilage volume loss during the year

Wang, Y.

, Jones, G.
, Hill, C.

Wang, Y.

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