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Systemic pustular psoriasis (GPP) is a rare, life-threatening inflammatory skin disease characterized by widespread outbreaks of sterile pustules
Recently, a research article was published in the top medical journal NEJM.
The primary end point of the study was the Generalized Pustular Psoriasis Physician’s Global Assessment (GPPGA) pustule score of 0 (range 0 [no visible pustules] to 4 [severe pustules] at the first week after treatment )
A total of 53 patients were recruited for the study: 35 were assigned to receive pesolizumab, and 18 were assigned to receive placebo
Infect
In this phase 2 randomized trial involving GPP patients, the interleukin-36 receptor inhibitor pesolimab had a higher clearance rate than placebo at 1 week, but it was related to infection and systemic drug reactions
The interleukin 36 receptor inhibitor Pesolizumab had a higher lesion clearance rate than placebo at 1 week, but it was related to infection and systemic drug reactions