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    Home > Active Ingredient News > Immunology News > NEJM: How effective is Pesolizumab in treating systemic pustular psoriasis?

    NEJM: How effective is Pesolizumab in treating systemic pustular psoriasis?

    • Last Update: 2021-12-24
    • Source: Internet
    • Author: User
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    Systemic pustular psoriasis (GPP) is a rare, life-threatening inflammatory skin disease characterized by widespread outbreaks of sterile pustules


    Recently, a research article was published in the top medical journal NEJM.


    The primary end point of the study was the Generalized Pustular Psoriasis Physician’s Global Assessment (GPPGA) pustule score of 0 (range 0 [no visible pustules] to 4 [severe pustules] at the first week after treatment )


    A total of 53 patients were recruited for the study: 35 were assigned to receive pesolizumab, and 18 were assigned to receive placebo


    Infect

    In this phase 2 randomized trial involving GPP patients, the interleukin-36 receptor inhibitor pesolimab had a higher clearance rate than placebo at 1 week, but it was related to infection and systemic drug reactions


    The interleukin 36 receptor inhibitor Pesolizumab had a higher lesion clearance rate than placebo at 1 week, but it was related to infection and systemic drug reactions


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