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A&R: The relationship between rheumatoid arthritis and lung function measurement indicators
Time of Update: 2021-12-26
Conclusion Conclusion : RA and the chance of restrictive and obstructive pulmonary mode increases related to this relationship can not be explained by confounding factors including smoking status .
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EULAR Recommendation: Core Data Set for Pregnancy Registration of Rheumatism
Time of Update: 2021-12-26
, These studies prospectively collect information about pregnant women with IRD, including the neonatal stage (4 weeks postpartum)Method: A step-by-step process includes two rounds of Delphi surveys and a face-to-face meeting to reach consensus on related projects .
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A&R: IL-34 reprograms glycolysis and osteoclast rheumatoid arthritis macrophages
Time of Update: 2021-12-26
The local expression of IL-34 induces arthritis by increasing glycolytic F4/80- positive and inducible nitric oxide synthase (iNOS) -positive macrophages, which in turn attract fibroblasts and polarized Th1/Th17 cells .
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A&R: Differences in the oral microbiome of patients with early rheumatoid arthritis and high-risk individuals with rheumatoid arthritis compared with healthy people
Time of Update: 2021-12-26
Results: There were no significant differences in the three periodontal variables between early RA patients, high-risk individuals and healthy controls ( BOP P = 0.
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J Invest Dermatol: Differences in clinical characteristics and comorbidity burden of more than 9,000 psoriasis patients with HLA-C*06:02 carrier group
Time of Update: 2021-12-26
Psoriasis is a chronic inflammatory skin disease mediated by T cells. It is a global health problem that affects at least 60 million people worldwide . Psoriasis has a complex genetic background.
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Best Practice & Research Clinical Rheumatology: New progress in crystal arthritis
Time of Update: 2021-12-26
In terms of anti-inflammatory prevention , the FORTUNE trial showed that the method to start lowering uric acid treatment is to start with a low dose and gradually ( use febuxostat to 40 mg within 8 weeks ) .
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Br J Dermatol: HSP90 inhibitor RGRN-305 in the treatment of plaque psoriasis
Time of Update: 2021-12-26
Here, we report the results of an open proof-of-concept study aimed at investigating the safety and effectiveness of RGRN-305 targeting HSP90 in patients with moderate to severe psoriasis .
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JEADV: Study on the correlation between seborrheic dermatitis and SARS-CoV-2
Time of Update: 2021-12-26
Taken together, these results indicate that, compared with other skin diseases, SD is not associated with a worse SARS-CoV-2 outcome, although it is potentially associated with immune disorders and the use of immunosuppressive agents .
J Eur Acad Dermatol Venereol 2021 Nov 22;Rakita U, Kaundinya T, Guraya A, Lack of association between seborrheic dermatitis and SARS-CoV-2 outcomes.
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Are inflammasomes related to autoimmune diseases in children?
Time of Update: 2021-12-26
A comprehensive multi-cohort comparison of inflammasome gene expression profiles in different pediatric rheumatism is needed to determine the subgroups of patients who may benefit from adjuvant therapy with IL-1β inhibitors .
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Lancet: Ianalumab (VAY736) in the treatment of moderate to severe primary Sjogren’s syndrome
Time of Update: 2021-12-25
Immune quality of lifeThe VAY736A2201 trial is a randomized, parallel, double-blind, placebo-controlled phase 2b dose exploratory study conducted in 56 centers in 19 countries to evaluate different doses of Ianalumab for moderate to severe primary dryness syndrome The safety and efficacy of the symptoms .
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NEJM: The effect of Tapinarof cream in the treatment of plaque psoriasis
Time of Update: 2021-12-25
During the 12-week treatment period, 1% Tapinarof cream once a day was better than the control ointment in reducing the severity of plaque psoriasis, but was related to local adverse events and headaches .
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A&R: Incidence and predictive characteristics of erosive hand osteoarthritis
Time of Update: 2021-12-25
Purpose : To assess age, gender, race, severity of osteoarthritis (OA) , metabolic factors, and bone health as baseline risk factors for erosive hand OA and the incidence over a 48 -month period .
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A&R: Estrogen-induced hsa-miR-10b-5p is elevated in T cells of patients with systemic lupus erythematosus and down-regulates the serine/arginine-rich splicing factor 1
Time of Update: 2021-12-25
41787Ramanujan, SA, Cravens, EN, Krishfield, SM, Kyttaris, VC and Moulton, VR (2021), Estrogen-Induced hsa-miR-10b-5p Is Elevated in T Cells From Patients With Systemic Lupus Erythematosus and Down-Regulates Serine/ Arginine-Rich Splicing Factor 1.
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A&R: Protein mannosylation as a diagnostic and prognostic biomarker for lupus nephritis
Time of Update: 2021-12-25
Further, the diagnosis when the diagnosis LN detecting renal biopsy sample from a patient to mannosylated predicted levels are shown to chronic kidney disease (CKD) development, specificity of 93% .
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Consensus guidelines for the evaluation and management of pulmonary disease in Sjogren’s syndrome
Time of Update: 2021-12-25
After identifying the urgent need for early diagnosis and improving the quality and consistency of care, the Sjögren Foundation developed clinical practice guidelines for the diagnosis, management, and treatment of Sjögren's pulmonary manifestations .
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JEADV: Ixekizumab can moderate to severe sexual effects related to genital psoriasis
Time of Update: 2021-12-25
J Eur Acad Dermatol Venereol 2021 Nov 23;Ryan C, Guenther L, Foley P, Ixekizumab provides persistent improvements in health-related quality of life and the sexual impact associated with moderate-to-severe genital psoriasis in adult patients during a 52-week, randomized, placebo-controlled, phase 3 clinical trial.
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A&R: CRTAC1 protein in plasma is associated with osteoarthritis and predicts whether joint replacement will be needed in the future: Large-scale proteomics scan in Iceland
Time of Update: 2021-12-25
Conclusion : Through a non-hypothetical method, this study identified CRTAC1 in plasma as a new candidate biomarker for OA , which is not only related to the occurrence of OA , but also predicts the progress of joint replacement .
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Arthritis Rheumatol: The effect of intra-articular corticosteroids and hyaluronic acid on the progression of knee osteoarthritis
Time of Update: 2021-12-25
The outcome was radiological progress based on Kellgren and Lawrence grades in the two cohorts, as well as joint space narrowing, medial joint space width of osteoarthritis initiative participants, and total knee arthroplasty .
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Clin Exp Allergy: Is the development of eczema still related to gender?
Time of Update: 2021-12-25
FLG LOF variants and paternal eczema are associated with a higher risk of early onset trajectories in men, while maternal eczema and high birth weight are associated with early onset trajectories in women .
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A&R: The enhancement of interferon gene stimulating factor induces the production of type I interferon in COPA syndrome
Time of Update: 2021-12-25
In vitro analysis showed that COPA V242G and previously reported pathogenic mutations enhanced the type I IFN promoter activity induced by stimulus of interferon gene (STING) .
