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Purpose : Lack of biomarkers for the diagnosis and progression of osteoarthritis (OA) .
This study aims to identify OA cycle biomarkers that can predict the occurrence of disease and / or the progression of joint replacement .
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This study aims to identify OA cycle biomarkers that can predict the occurrence of disease and / or the progression of joint replacement .
Method: Use the SomaScan platform (using the proximity extension method to measure protein to detect the specificity of SomaScan)
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Method:Method: Use the SomaScan platform (using the proximity extension method to measure protein to detect the specificity of SomaScan)
Results:Results: Among the large number of plasma proteins evaluated, cartilage acid protein 1 (CRTAC1) has the strongest correlation with the two OA diagnoses ( odds ratio of knee OA , OR 1.
ConclusionConclusion : By no hypothetical method, the study plasma CRTAC1 identified as a new OA biomarker candidates, both with OA occurs about, but also to predict the progression of joint replacement
Source:
Styrkarsdottir, U.
, Lund, SH, Saevarsdottir, S.
Styrkarsdottir, U.
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