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A large amount of literature has shown that the dysregulated interaction between genes and the environment can lead to human autoimmune diseases
.
Inflammasomes are multi-protein complexes that play an important role in sensing pathogens and cell disturbances, including pathogen-related molecular patterns (PAMP), danger-related molecular patterns (DAMP), and homeostasis alteration molecular processes (HAMP)
Inflammasomes are multi-protein complexes that play an important role in sensing pathogens and cell disturbances, including pathogen-related molecular patterns (PAMP), danger-related molecular patterns (DAMP), and homeostasis alteration molecular processes (HAMP)
The inflammasome is at the center of the interaction between genes and the environment, and the disorder of the inflammasome pathway may lead to auto-inflammation or autoimmune diseases
Discussed the use of IL-1 receptor antagonists as adjuvant therapy for several autoimmune diseases in children, including COVID-19- related macrophage activation syndrome (MAS) and childhood multiple system inflammatory syndrome (MIS-C) COVID-19
The mechanism of inflammasome activation in children's rheumatism :
The mechanism of inflammasome activation in childhood rheumatismMutations in single-gene autoinflammatory diseases:
Mutations in single-gene autoinflammatory diseases:Risk alleles and gene disorders involving inflammasomes in children with rheumatism:
Risk alleles and gene disorders involving inflammasomes in children with rheumatism:Protein markers related to the activation of inflammasomes and their association with the course of the disease:
Protein markers related to the activation of inflammasomes and their association with the course of the disease:Inflammasomes are involved in MAS and JSLE:
Inflammasomes are involved in MAS and JSLE:Activation of NLRP3 inflammasome in COVID-19
.
The components of SARS-CoV-2 can directly (viral porin 3a and ORF8b) or indirectly activate the NLRP3 inflammasome
Activation of NLRP3 inflammasome in COVID-19
In summary, evidence of inflammasome activation can be found in polygenic childhood autoimmune diseases
.
Among these polygenic diseases, SJIA and KD show the strongest IL-1 signal characteristics, and anti-IL-1 receptor therapy has been recommended in a subgroup of these patients
Among these polygenic diseases, SJIA and KD show the strongest IL-1 signal characteristics, and anti-IL-1 receptor therapy has been recommended in a subgroup of these patients
Original: Yang CA, Chiang BL.
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