-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Tapinarof cream is a topical aromatic hydrocarbon receptor modulator, which is being studied for the treatment of psoriasis
.
Tapinarof cream can regulate the expression of interleukin 17 and skin barrier proteins filaggrin and loricrin
.
Recently, the top medical journal NEJM published a research article in which researchers conducted two identical phase 3 randomized trials in patients with mild to severe plaque psoriasis
.
Patients with a baseline physician’s overall assessment (PGA) score of 2 (mild) to 4 (severe) (range 0 to 4, the higher the score, the more severe the psoriasis) and the area of the disease that accounts for 3 to 20% of the total surface area is 2 The ratio of 1: 1 was randomly assigned to use 1% tapinarof cream or control cream once a day for 12 weeks of continuous treatment
.
The primary endpoint of the study was the PGA response, that is, a PGA score of 0 (cleared) or 1 (almost cleared) and a decrease of at least 2 points from baseline at week 12
.
The secondary efficacy endpoint of the study is a reduction of at least 75% in the Psoriasis Area and Severity Index (PASI) score, a PGA score of 0 or 1, the average change in the percentage of affected body surface area from baseline, and a reduction in the PASI score of at least 90 %
.
Quality of Life
In trials 1 and 2, the study screened a total of 692 and 674 patients, respectively, of which 510 and 515 patients were included
.
In trial 1, 35.
4% of the patients in the Tapinarof ointment group and 6.
Infect
It can be seen that in the 12-week treatment period, 1% Tapinarof cream once a day is better than the control ointment in reducing the severity of plaque psoriasis, but it is related to local adverse events and headaches
.
Compared with existing treatments for psoriasis, larger and longer-term trials are needed to evaluate the efficacy and safety of Tapinarof cream
.
During the 12-week treatment period, 1% Tapinarof cream once a day was better than the control ointment in reducing the severity of plaque psoriasis, but was related to local adverse events and headaches