-
J Autoimmun: Phosphatase controls cytokine-mediated overproduction of galactose-deficient IgA1 ( the main autoantigen for IgA nephropathy )
Time of Update: 2022-09-07
SiRNA knockdown of SOCS1 and associated SOCS3 increases Gd-IgA1 production in cells from healthy control PBMCs, indicating the role of these regulators in abnormal cytokine signaling and Gd-IgA1 overproduction.
-
J Autoimmun: Renal and vascular outcomes in patients with nephropathy with simple antiphospholipid syndrome
Time of Update: 2022-09-07
Conclusion: The renal prognosis of isolated APSN is poor, and 6 patients develop ESRD.
Conclusion: The renal prognosis of isolated APSN is poor, and 6 patients develop ESRD.
Conclusion: The renal prognosis of isolated APSN is poor, and 6 patients develop ESRD.
-
Several tests must be done by patients with high uric acid and gout!
Time of Update: 2022-09-07
Many patients with high uric acid and gout will have symptoms such as joint redness, swelling, and severe pain in the early stage of the disease, but they have not been diagnosed through detailed diagnosis, and they have missed the best treatment period, which has a great impact on the patient's future life .
-
Joint pain, must be rheumatoid?
Time of Update: 2022-09-07
Therefore, when you have joint pain, you do not necessarily have rheumatoid arthritis .
Therefore, when you have joint pain, you do not necessarily have rheumatoid arthritis .
Therefore, when you have joint pain, you do not necessarily have rheumatoid arthritis .
-
First discovery: In this population, low uric acid is associated with a high risk of death!
Time of Update: 2022-09-07
7 mg/dl, higher SU levels (per 1 mg/dl) were associated with a higher risk of death, which persisted after adjusting for DXA-derived body composition and historical weight loss exist .
-
Super detailed clinical experience, Professor Li Caifeng explained the diagnosis and treatment of MAS
Time of Update: 2022-09-07
*For medical professionals onlyEarly warning, active treatment, and lighting up hope for the lives of MAS patients. Macrophage activation syndrome (MAS) is a hemophagocytic lymphocytosis (HLH, also kn
-
Nature BE: Li Lele's team achieved real-time dynamic imaging and early diagnosis of inflammation-related mRNA in vivo
Time of Update: 2022-09-07
The study designed and constructed an inflammatory cell-specific signal amplification method based on enzyme-triggered molecular beacons, which achieved real-time dynamic imaging and early diagnosis of inflammation by spatially selectively amplifying inflammation-related RNA imaging signals.
-
Why do rheumatologists do a "blood routine" test?
Time of Update: 2022-09-07
Decreased red blood cell countIt is common in systemic lupus erythematosus, with hemolytic anemia as the first symptom of systemic lupus erythematosus in many cases, others also seen in rheumatoid arthritis, Sjogren's syndrome, aortic arteritis, systemic sclerosis, polymyositis/dermatomyositis.
-
Interpretation of Evidence-Based Medication Guidelines for High-Dose Methotrexate in China
Time of Update: 2022-09-07
Guideline name: Interpretation of Evidence-Based Medication Guidelines for High-Dose Methotrexate in ChinaEnglish title:Publisher: Department of Pharmacy, Peking University Third HospitalRelease date:
-
This type of vasculitis combined with dura mater, 6 characteristics to know!
Time of Update: 2022-09-07
Download the Doctor Station App and subscribe anytime, anywhere~*For medical professional reading reference onlyClinical information, reachable in 1s ▎Clinical question: What are the characteristics of hypertrophic dura mater (HP) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)?Screenshot of the literature▎Research protocol: This study included the clinical data of 663 Asian AAV patients (mean age 70.
-
Rheumatoid online recognizes anticyclic citrullinic acid protein (CCP) antibodies
Time of Update: 2022-09-07
Anti-CCP antibodies can be positive early in the course of RA and even before joint symptoms appear and are not associated with RF.
Anti-CCP antibodies can be positive early in the course of RA and even before joint symptoms appear and are not associated with RF.
-
J Autoimmun : SB431542 relieves lupus nephritis by regulating B cells and inhibiting TLR9/TGFβ1/PDGFB signaling
Time of Update: 2022-09-07
In addition, SB431542 treatment not only inhibited B cell infiltration in the spleen and kidneys, but also downregulated the systemic and local TLR9/TGFβ1/PDGFB signaling in these mice.
-
ARD: Loss-of-function variants in SAT1 cause X-linked childhood systemic lupus erythematosus
Time of Update: 2022-09-06
Conclusions: This study identifies two novel SAT1 loss-of-function (LOF) variants, shows the ability of frameshift mutations to confer lupus, highlights the pathogenic role of dysregulated polyamine catabolism, and identifies SAT1 LOF variants for a new monogenic cause of SLE .
-
Expert consensus on chronic disease management in patients with rheumatoid arthritis
Time of Update: 2022-09-06
RA is an autoimmune, systemic, chronic inflammatory polyarthritis for which there is currently no cure . As the course of RA progresses, patients will experience joint deformities, disability, and los
-
ARD: Over 30,000 Data Study: Efficacy of TNF Inhibitors, Abatacept, IL6 Inhibitors, and JAK Inhibitors in Patients with Rheumatoid Arthritis
Time of Update: 2022-09-06
Background: Several second-line treatment options are available to rheumatologists and patients for patients with rheumatoid arthritis who have an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (DMARDs) or who have contraindications .
-
Rheumatoid Arthritis Diet Dos and Don'ts List
Time of Update: 2022-09-06
Based on the understanding of TCM and Western medicine on the pathogenesis of rheumatoid arthritis, patients with rheumatoid arthritis should pay special attention to diet, which can aggravate the immune system disorder and TCM believes that it is the occurrence of wind, cold accumulation, dampness, and heat.
-
X-linked agammaglobulinemia: signs and symptoms, etiology, epidemiology, diagnosis, and treatment
Time of Update: 2022-09-06
X-linked agammaglobulinemia (XLA) is an X-linked recessive genetic disorder that is a primary immunodeficiency disease caused by a developmental disorder of the B-cell series in humans.
-
【Cell】Structural images of T cell receptors, revealing the mechanism of action of T cell receptors!
Time of Update: 2022-09-06
Researchers led by Lukas Suñac, Christoph Thomas and Robert Tampé of the Institute of Biochemistry at the University of Frankfurt, in collaboration with Simon Davis of the University of Oxford and Gerhard Hummer of the Max Planck Institute for Biophysics, have for the first time successfully visualized an antigen-binding protein in the Structure of the membrane-bound T-cell receptor complex together .
-
Can Rheumatoid Arthritis Be Disabled by Improper Treatment?
Time of Update: 2022-09-06
Simiao Xiaobi Decoction has good overall therapeutic effectIn the current clinical practice, rheumatoid arthritis is often treated by controlling the disease and improving the prognosis, and the earlier the intervention, the better the effect .
-
Is Rheumatoid Arthritis Curable?
Time of Update: 2022-09-06
It is recommended that patients with early symptoms such as morning stiffness and joint swelling and pain should go to the rheumatology and immunology department of the hospital for treatment in time .