Rheumatoid online recognizes anticyclic citrullinic acid protein (CCP) antibodies

Editor's Introduction

When it comes to rheumatoid arthritis (RA) autoantibodies, do you naturally think of rheumatoid factor (RF) and anticyclic citrullinide peptide (CCP) antibodies? In fact, in addition to anti-CCP antibodies, autoantibodies against citrullin proteins such as anti-perinuclear factor (APF), anti-keratin antibodies (AKA), anti-Sa antibodies, anti-mutant citrulline waveform protein (MCV) antibodies, etc.

Today, Xiaobian will take you to deeply understand these autoantibodies against citrullin proteins, classify and summarize, and facilitate everyone's memory

Anti-CCP antibodies are of great concern

APF antigen component is an insoluble protein present in the cytoplasm of buccal mucosal epithelial cells, which has a good linear relationship with RA, and its diagnostic specificity for RA increases with the increase of antibody titers, but there is no obvious correlation with RF, but it is closely related

AKA is an IgG-type antibody that reacts specifically to ra specifically with the components of the stratum corneum, and the serum AKA level is positively correlated with the main symptoms of RA, such as the duration of morning stiffness, the degree and extent of joint tenderness, and the patient's persistent high level of AKA suggests severe disease and poor

Anti-Sa antibodies are highly specific

MCV is a product of the protein structure change after the granullinization of the peptide-arginine ammonidase (PAD), and the waveform protein persists in the apoptotic cells because it is not cleared in time, thereby promoting the production