-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Introduction: The vertebrate immune system is a powerful weapon against cancer cells and foreign pathogens
For T cells that coordinate adaptive responses, the solution is to convert pathogens and tumors into short (up to 24 residues) peptides for presentation to the T cell receptor (TCR) as a major histocompatibility complex (MHC) A complex of proteins (peptide-loaded MHC [pMHC])
Many surface receptors transmit signals to the interior of cells by changing their spatial structure upon ligand binding
https://doi.
01Research process
For structural analysis, the researchers selected a T-cell receptor for melanoma for immunotherapy treatment and optimized several steps to bind its antigen as tightly as possible
With the completion of the collection of images on the cryo-electron microscope, providing breakthrough insights into how T cell receptors work, as Tampé said: "On the basis of our structural analysis, we were able to show that the T cell receptors work.
Cryo-electron microscopy analysis of pMHC-linked TCRs
02
The structure of the gp100/HLA-A2/TCR complex was determined by cryo-electron microscopy using an all-gold scaffold of hydrophilic graphene monolayers to preserve the fully assembled multiprotein complex
03Future Outlook
An unresolved question of research is how antigen binding leads to T cell activation
"Our structure is a blueprint for future research on T cell activation," Tampé said
References:
https://phys.
https://doi.
