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The HSS study revealed how ultraviolet light triggers immune activation and disease outbreaks in lupus patients
Time of Update: 2022-12-04
In a new study presented at the ACR Proceedings of the American College of Rheumatology 2022 Annual Meeting, researchers from the Hospital for Special Surgery (HSS) report that they have discovered a potential mechanism explaining this association: reduced lymphatic drainage, which contributes to the creation of photosensitivity and immune responses in lymph nodes.
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The immune system in MS patients is restarted
Time of Update: 2022-12-04
Removes useless immune cells"80% of patients are disease-free for a long time or permanently after receiving an autologous hematopoietic stem cell transplant," said recently retired Professor Roland Martin, who led the study and last author.
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Rice bioengineers look for better signals from cells
Time of Update: 2022-12-04
Jerzy Szablowski, a rice bioengineer who received the National Institutes of Health Trailblazer Award, developed a non-invasive, site-specific reporter secreted by cells to measure gene expression in deep tissues, particularly the brain.
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World Diabetes Day: Restoring blood sugar control to diabetic mice!
Time of Update: 2022-12-04
The technology, which builds on earlier work at Stanford School of Medicine, could open the door to a new type of organ transplant that doesn't require an immune-matched donor or years of immunosuppressive drugs.
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The length of REM sleep is related to body temperature
Time of Update: 2022-12-04
Siegel said the findings suggest a previously unobserved relationship between body temperature and rapid eye movement sleep (REM), the brain's highly active sleep phase.
Siegel said the findings suggest a previously unobserved relationship between body temperature and rapid eye movement sleep (REM), the brain's highly active sleep phase.
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CRISPR treatment reduces swelling in patients with hereditary angioedema
Time of Update: 2022-12-04
”In vivo CRISPR-Cas9 editing of KLKB1 in Patients with Hereditary Angioedema-A First-in-Human Study Danny Cohn, MD, senior author of the study, said: "Although the data are still increasing, plasma kininase levels decreased rapidly and significantly in all patients in the 25- and 75 mg dose groups treated with a single dose of NTLA-2002.
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Cell has released the largest whole genome sequencing study on autism, revealing 134 autism-related genes
Time of Update: 2022-12-04
Researchers at SickKids have identified new genes and genetic changes associated with autism spectrum disorder (ASD) in the largest whole-genome sequencing analysis of autism to date, leading to a better understanding of the "genomic structure" behind the disorder.
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Cell: The intravenous cancer vaccine is satisfactory
Time of Update: 2022-12-04
Researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, report that an experimental therapeutic cancer vaccine induced two different, satisfactory immune system responses that led to significant tumor regression in mice.
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The laboratory of Jingwei Xiong of the Institute of Future Technology found that neutrophil DUSP6 deficiency improves cardiac regeneration and repair
Time of Update: 2022-11-26
On November 5, 2022, Professor Jingwei Xiong's research group from the School of Future Technology of Peking University published an online report entitled "Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in acute inflammatory phase of" online in the journal Nature Communications myocardial infarction", which found that deletion of the Dusp6 gene can improve cardiac repair after myocardial infarction in rats and mice by reducing the killing effect of neutrophils on the myocardium during the inflammatory response period after myocardial infarction.
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Nature sub-issue: "Someone else" that causes Alzheimer's disease tau neurotoxicity
Time of Update: 2022-11-26
Researchers from Indiana University School of Medicine have identified a protein that interacts and promotes the spread of the neurotoxic tau, which is mainly found in neurons that appear abnormal in the brains of Alzheimer's patients.
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PNAS: Newly discovered cancer cell biology indicates which patients respond to immunotherapy
Time of Update: 2022-11-26
1 alterations in HPV- head and neck squamous cancer dictate immune microenvironment and anti-PD-1 inhibitor activity A new study found that patients with head and neck cancer who received immunotherapy had more genetic material on chromosome 9 in their cancer cells survived three times longer than those with less genetic material on chromosome 9.
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New progress has been made in the mechanism of maize MYC2s regulating maize insect resistance response by Kunming plants
Time of Update: 2022-11-26
The study, titled ZmMYC2s play important roles in maize responses to simulated herbivory and jasmonate, was published online in the Journal of Integrative Plant Biology Ma Canrong, a doctoral student at the Kunming Institute of Botany, Chinese Academy of Sciences, is the first author of the paper, and researcher Wu Jianqiang and associate researcher Wang Lei are co-corresponding authors.
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The basic research team of orthopedics of the Ninth Affiliated Hospital has made new breakthroughs in the field of infection diagnosis and treatment
Time of Update: 2022-11-26
Difficulties in early diagnosis of bacterial infections of implants and easy recurrence after treatment are two very difficult problems for orthopedic surgeons. There is no significant change in imag
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Effects of exposure to fine atmospheric particulate matter and its main components during pregnancy on cognitive and motor performance in 1-year-old children
Time of Update: 2022-11-26
5 exposure in the third trimester and the whole pregnancy showed a significant negative association with gross motor movements, problem solving, and personal-social energy zone scores.
5 exposure in the third trimester and the whole pregnancy showed a significant negative association with gross motor movements, problem solving, and personal-social energy zone scores.
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Nature: Challenge the norm! The higher the viscosity of the extracellular fluid, the easier it is for cancer cells to metastasize from the primary tumor to other parts of the body
Time of Update: 2022-11-26
These authors reveal physical cues about how cells sense and respond to increased viscosity, and how the cytoskeleton, which controls cell shape and intracellular structure and participates in cell movement, works with ion channels and ion transporters--- protein --- that guide charged molecules through the cell membrane to regulate efficient migration at high viscosities.
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IGF1 gene therapy slows reproductive aging in middle-aged female rats by affecting hypothalamic GnRH and kisspeptin neurons
Time of Update: 2022-11-26
"IGF1 gene therapy in middle-aged female rats delays, reproductive senescence through its effects on hypothalamic, GnRH and kisspeptin neurons Image: Figure 7.
"IGF1 gene therapy in middle-aged female rats delays, reproductive senescence through its effects on hypothalamic, GnRH and kisspeptin neurons Image: Figure 7.
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The shortest wavelength fluorescence reported to date makes dynamic cell imaging easier
Time of Update: 2022-11-26
Article Extension of the short wavelength side of fluorescent proteins using hydrated chromophores, and its application Figure: Chromatophore structure of a shortwave-edged avGFP mutantImage credit: Kazunori SugiuraOSAKA, Japan — Imagine how difficult it is to visually track five people scattered across a stadium.
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Chinese scholars and overseas collaborators have made progress in the research of stable learning inspired by cause and effect
Time of Update: 2022-11-26
Figure Causal Inspired Stable Learning Research Framework and Progress The heterogeneity and uncertainty of real data in an open environment pose severe challenges to the interpretability and general
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Fang Xiaofeng's research group in the School of Life Sciences and its collaborators jointly revealed the mechanism of plants coping with osmotic stress
Time of Update: 2022-11-26
Interestingly, SEU (removal of IDR1 or removal of α-helix structure in IDR1) without the ability to respond to phase separation of osmosis can completely complement the growth and development phenotype of its mutant under normal growth conditions, but cannot complement the sensitive phenotype of mutants under osmotic stress, indicating that SEU positively regulates the tolerance of plant cells to hypertonic stress through its aggregates.
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Fluorescent blood mice
Time of Update: 2022-11-26
”Because this new method induces mice to produce harmless fluorescent proteins to label blood, rather than chemical dyes, mice only need to be injected once, rather than multiple times and every few hours.