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New findings may solve the mystery of Parkinson's disease
Time of Update: 2022-11-26
References:Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models According to a recent study by scientists at Weill Cornell Medical College, protein-α synuclein aggregates spread through the brains of Parkinson's disease patients through a process of cellular waste injection.
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Look for the disrupted brain signals behind autism
Time of Update: 2022-11-26
In different experiments, the scientists found that the signal changes associated with suppressor cells, seen shortly after birth in mouse models of the same autism spectrum disorder (ASD) gene, may not be enough to interfere with normal brain development driven by other genes.
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The Institute of Aquatic Sciences has made progress in the study of the spatial distribution characteristics of nitrogen and the relationship between DOM in degraded large shallow lakes
Time of Update: 2022-11-26
Recently, the team of Wu Zhenbin, a researcher at the Institute of Hydrobiology, Chinese Academy of Sciences, took Honghu, a typical large shallow lake in the middle and lower reaches of the Yangtze River (Figure 1), and analyzed the spatial heterogeneity and coupling correspondence between different spatial nitrogen morphological composition, DOM composition, humification degree, and the intrinsic response relationship between microorganisms as the starting points.
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A better model of type 2 diabetes
Time of Update: 2022-11-26
While researchers have been using common laboratory mice and rats to improve our understanding of the disease, tracking the development of diet-induced diabetes and its complications in more typical rodent models has not yielded much rewards.
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The JMG:SHROOM4 gene plays an important role in embryonic development
Time of Update: 2022-11-26
”Original searchX-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems A study led by the Medical School of the University of Bonn in Germany found a gene that plays an important role in the development of human embryos.
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MIT: Genome-wide studies of mouse livers using the gene-editing system CRISPR
Time of Update: 2022-11-26
In a paper describing the technique, the researchers identified several genes important for liver cell survival and proliferation that had not previously been found in studies of cells grown in laboratory dishes.
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The shortest wavelength fluorescence reported to date makes dynamic cell imaging easier
Time of Update: 2022-11-26
Article Extension of the short wavelength side of fluorescent proteins using hydrated chromophores, and its application Figure: Chromatophore structure of a shortwave-edged avGFP mutantImage credit: Kazunori SugiuraOSAKA, Japan — Imagine how difficult it is to visually track five people scattered across a stadium.
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PNAS: Newly discovered cancer cell biology indicates which patients respond to immunotherapy
Time of Update: 2022-11-26
1 alterations in HPV- head and neck squamous cancer dictate immune microenvironment and anti-PD-1 inhibitor activity A new study found that patients with head and neck cancer who received immunotherapy had more genetic material on chromosome 9 in their cancer cells survived three times longer than those with less genetic material on chromosome 9.
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Chinese scholars have made progress in multimodal datasets and related research for mental disorders
Time of Update: 2022-11-26
Figure Data-driven quantitative research methods According to WHO statistics and forecasts, there are more than 300 million people with depression in the world, and depression will rank first in the global burden of disease by 2030.
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Nature: Challenge the norm! The higher the viscosity of the extracellular fluid, the easier it is for cancer cells to metastasize from the primary tumor to other parts of the body
Time of Update: 2022-11-26
These authors reveal physical cues about how cells sense and respond to increased viscosity, and how the cytoskeleton, which controls cell shape and intracellular structure and participates in cell movement, works with ion channels and ion transporters--- protein --- that guide charged molecules through the cell membrane to regulate efficient migration at high viscosities.
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New progress has been made in the mechanism of maize MYC2s regulating maize insect resistance response by Kunming plants
Time of Update: 2022-11-26
The study, titled ZmMYC2s play important roles in maize responses to simulated herbivory and jasmonate, was published online in the Journal of Integrative Plant Biology Ma Canrong, a doctoral student at the Kunming Institute of Botany, Chinese Academy of Sciences, is the first author of the paper, and researcher Wu Jianqiang and associate researcher Wang Lei are co-corresponding authors.
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Cell Systems: X chromosome silencing for some male cancers
Time of Update: 2022-11-26
But in the new study, the researchers found high levels of XIST RNA in male somatic cells sampled from cancer tissue.
But in the new study, the researchers found high levels of XIST RNA in male somatic cells sampled from cancer tissue.
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Nature sub-issue: "Someone else" that causes Alzheimer's disease tau neurotoxicity
Time of Update: 2022-11-26
Researchers from Indiana University School of Medicine have identified a protein that interacts and promotes the spread of the neurotoxic tau, which is mainly found in neurons that appear abnormal in the brains of Alzheimer's patients.
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Fang Xiaofeng's research group in the School of Life Sciences and its collaborators jointly revealed the mechanism of plants coping with osmotic stress
Time of Update: 2022-11-26
Interestingly, SEU (removal of IDR1 or removal of α-helix structure in IDR1) without the ability to respond to phase separation of osmosis can completely complement the growth and development phenotype of its mutant under normal growth conditions, but cannot complement the sensitive phenotype of mutants under osmotic stress, indicating that SEU positively regulates the tolerance of plant cells to hypertonic stress through its aggregates.
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Chinese scholars and overseas collaborators have made progress in the research of stable learning inspired by cause and effect
Time of Update: 2022-11-26
Figure Causal Inspired Stable Learning Research Framework and Progress The heterogeneity and uncertainty of real data in an open environment pose severe challenges to the interpretability and general
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The laboratory of Jingwei Xiong of the Institute of Future Technology found that neutrophil DUSP6 deficiency improves cardiac regeneration and repair
Time of Update: 2022-11-26
On November 5, 2022, Professor Jingwei Xiong's research group from the School of Future Technology of Peking University published an online report entitled "Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in acute inflammatory phase of" online in the journal Nature Communications myocardial infarction", which found that deletion of the Dusp6 gene can improve cardiac repair after myocardial infarction in rats and mice by reducing the killing effect of neutrophils on the myocardium during the inflammatory response period after myocardial infarction.
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Fluorescent blood mice
Time of Update: 2022-11-26
”Because this new method induces mice to produce harmless fluorescent proteins to label blood, rather than chemical dyes, mice only need to be injected once, rather than multiple times and every few hours.
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The basic research team of orthopedics of the Ninth Affiliated Hospital has made new breakthroughs in the field of infection diagnosis and treatment
Time of Update: 2022-11-26
Difficulties in early diagnosis of bacterial infections of implants and easy recurrence after treatment are two very difficult problems for orthopedic surgeons. There is no significant change in imag
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IGF1 gene therapy slows reproductive aging in middle-aged female rats by affecting hypothalamic GnRH and kisspeptin neurons
Time of Update: 2022-11-26
"IGF1 gene therapy in middle-aged female rats delays, reproductive senescence through its effects on hypothalamic, GnRH and kisspeptin neurons Image: Figure 7.
"IGF1 gene therapy in middle-aged female rats delays, reproductive senescence through its effects on hypothalamic, GnRH and kisspeptin neurons Image: Figure 7.
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A new device for measuring neural activity and treating sepsis and post-traumatic stress disorder
Time of Update: 2022-11-26
To explore the type of human autonomic organism, a population of patients whose involuntary nervous systems respond similarly to stress, the researchers conducted a series of tests in which study participants were asked to put their hands in ice water and then perform timed breathing exercises.
