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The "CAR pool" screens to identify the most effective cancer immunotherapy cells
Time of Update: 2022-12-04
Simplify T cell detectionRoybal, Goodman and co-first author Camillia Azimi developed CAR-pools to rapidly test the effectiveness of different CARs. The screening works by generating a DNA library containing the genetic code of many immune receptors, introducing them into millions of cells that then compete in a test tube for skills to survive, grow, recognize and destroy cancer.
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Cell Stem Cell, a "nerve-specific" protein that can heal the heart
Time of Update: 2022-12-04
According to research led by Dr. Li Qian of the University of North Carolina School of Medicine, a protein that helps neurons develop also has the function of reprogramming scar tissue cells into cardiomyocytes.
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Levels of three proteins in the blood can help detect undiagnosed prediabetes
Time of Update: 2022-12-04
Scientists have used proteomics methods to identify signatures of three proteins in the blood, which could improve detection of isolated impaired glucose tolerance, a form of prediabetes.
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Cancer cell immune transformation nanotechnology platform
Time of Update: 2022-12-04
In this study, the researchers used BiTN with SLAMF7 and Her2-recognizing antibodies to target Her2-positive breast cancer cells.
In this study, the researchers used BiTN with SLAMF7 and Her2-recognizing antibodies to target Her2-positive breast cancer cells.
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Nature sub-journal: Genome evolution of allium crops and the formation mechanism of special spicy flavors
Time of Update: 2022-12-04
Allium is the world's second largest vegetable cash crop after tomatoes, and because it is rich in unique spicy flavors, it is often used in vegetables, condiments or medicinal plants and is widely c
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Simulating Life: Breakthroughs in Non-Living Materials
Time of Update: 2022-12-04
Image source: Delft University of TechnologyResearchers in Irkoma's lab have discovered a new process that uses fuel to control non-biological matter, similar to the function of living cells.
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The success of the CRISPR cancer trial paved the way for personalized treatment
Time of Update: 2022-12-04
"After a series of analyses to confirm their findings, validate their predictions, and design a protein called the T cell receptor, which recognizes tumor mutations, the researchers took blood samples from each participant and inserted the receptor into their T cells using CRISPR genome editing.
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The University of Pennsylvania has discovered why the cancer recurs due to BRCA mutations
Time of Update: 2022-12-04
In a new study published this week in Nature Communications, researchers compared a group of tumors from patients with primary and recurrent BRCA1/2 mutation-associated breast and ovarian cancers and found multiple features associated with recurrence, including those that promise to improve the ability of tumor repair treatments to cause DNA damage.
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PNAS: Copper is a clue to fighting cancer
Time of Update: 2022-12-04
" We believe Memo1 protects cancer cells by binding copper when needed so they can continue to survive and spread," said Pernilla Wittung-Stafshede, one of the study's lead authors.
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Cancer Cell: A potential treatment for deadly childhood cancer
Time of Update: 2022-12-04
essayCancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma Image: Sheila Singh (left) and first author and postdoctoral researcher William GwynneSource: McMaster UniversityA study led by McMaster University says an enzyme that promotes the growth of deadly brain cancers in children could be key to future treatments.
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Science offers a new idea of cancer: the perfect combination of genetic alterations that tumors use to promote explosive growth and prevent their own death
Time of Update: 2022-12-04
essayTPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma Dr. Jonathan Alder is an assistant professor in the Department of Pulmonary, Allergy and Critical Care Medicine at the University of Pittsburgh School of MedicineImage source: University of PittsburghScientists at the University of Pittsburgh School of Medicine have discovered the missing piece of the puzzle in the mystery of how melanoma controls its mortality.
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Nature Medicine: Repeated infection with COVID-19 increases the risk of organ failure and death
Time of Update: 2022-12-04
Researchers led by Al-Aly found that repeated infections with SARS-CoV-2 added significant additional risks to poor health in multiple organ systems.
Researchers led by Al-Aly found that repeated infections with SARS-CoV-2 added significant additional risks to poor health in multiple organ systems.
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The Xinjiang Institute of Habitats has made progress in the study of global flood occurrence time and driving mechanism
Time of Update: 2022-12-04
In response to the above problems, Chen Yaning's team from the State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, selected 6167 hydrological stations based on GRDC dataset and GSIM dataset, and evaluated the change trend of global flood occurrence time.
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Scientists apply Prime Editing technology to small standing bowls of moss and potatoes
Time of Update: 2022-12-04
Recently, researchers at the University of Saclay in Paris, France, successfully applied Prime Editing technology to two plants, small standing moss and potato, paving the way for future precision crop breeding.
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Society for Neuroscience Young Scientist Achievement and Research Award 2022
Time of Update: 2022-12-04
Gina Turrigiano, Chair of SfN, said: "This year's Young Prize winners demonstrate the fearless creativity and tenacity needed to make foundational discoveries in the field of neuroscience, and the breadth of their work illustrates the diversity of approaches needed to gain a deeper understanding of the interactions between neural activity, behaviour and health.
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The article "Nature-Communication: Earth and Environment", where Xinjiang's birthplace is located, reveals that the ancient Asian Ocean finally closed in the early Triassic
Time of Update: 2022-12-04
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CRISPR treatment reduces swelling in patients with hereditary angioedema
Time of Update: 2022-12-04
”In vivo CRISPR-Cas9 editing of KLKB1 in Patients with Hereditary Angioedema-A First-in-Human Study Danny Cohn, MD, senior author of the study, said: "Although the data are still increasing, plasma kininase levels decreased rapidly and significantly in all patients in the 25- and 75 mg dose groups treated with a single dose of NTLA-2002.
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Nature: Using spatial genomics to understand how breast cancer cloning evolved
Time of Update: 2022-12-04
Recently, an international research team used spatial genomics technology to map different clones in two patients' breast tumors.
Recently, an international research team used spatial genomics technology to map different clones in two patients' breast tumors.
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Cell: The intravenous cancer vaccine is satisfactory
Time of Update: 2022-12-04
Researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, report that an experimental therapeutic cancer vaccine induced two different, satisfactory immune system responses that led to significant tumor regression in mice.
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Cell has released the largest whole genome sequencing study on autism, revealing 134 autism-related genes
Time of Update: 2022-12-04
Researchers at SickKids have identified new genes and genetic changes associated with autism spectrum disorder (ASD) in the largest whole-genome sequencing analysis of autism to date, leading to a better understanding of the "genomic structure" behind the disorder.
