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Cell discovers the "hub" of immune cells hidden in tumors
Time of Update: 2021-09-13
Using these new analytical tools, the research team found that specific genetic programs and cell types are only present in MMRd tumors, which are more sensitive to immunotherapy .
Regev said: "Observing the co-mutation process in different cell types provides a new perspective for this complex tumor ecosystem .
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Chinese scholars have made progress in the research of storage-computing integrated devices
Time of Update: 2021-09-13
Focusing on this problem, a collaborative team such as Associate Professor Ye Lei and Researcher Hu Weida took a different approach and constructed a new type of homogenous transistor-memory device structure by using the physical mechanism of two-dimensional materials and the close neighbor coupling of the ferroelectric substrate .
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Chinese experts discover new treatment targets for children with medulloblastoma
Time of Update: 2021-09-13
In vivo and in vitro experiments have shown that microRNA molecules derived from exosomes play an important role in the occurrence and development of childhood medulloblastoma, and can become a potential diagnostic and therapeutic target for children with medulloblastoma .
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A new method for quantitative determination of the phase separation characteristics of chromatin-related proteins under physiological conditions
Time of Update: 2021-09-13
In the cell nucleus, biological macromolecules such as proteins form biomolecular aggregates through liquid-liquid phase separation (LLPS), which have been reported to be closely related to gene expression 1, chromatin higher structure 2, and so on .
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Cell Rep: Fundamentally prevent brain cancer
Time of Update: 2021-09-13
"The researchers discovered that a protein called galectin 1 interacts with another protein called HOXA5 to control the genetic programs that drive cancer stem cell behavior .
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Nature Microbiology: High numbers of viruses in the lungs lead to high mortality from COVID-19
Time of Update: 2021-09-13
"Our findings indicate that the body cannot cope with the large number of viruses that infect the lungs, which is largely the cause of deaths from COVID-19 in the pandemic," the lead author of the study and a part-time job in the Department of Medicine, New York University Langone School of Health Professor Imran Sulaiman, MD said .
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Regarding the delta strain and vaccination, Zhong Nanshan and Zhang Boli have the latest research and judgment
Time of Update: 2021-09-13
What level must China achieve to achieve "herd immunity"?Zhong Nanshan said that this is not only related to the effectiveness of the vaccine, but also depends on the spread coefficient of the virus .
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Received US$3 billion from Roche to help develop gene therapies for diseases such as Alzheimer's disease
Time of Update: 2021-09-13
Today, Shape Therapeutics announced that it has reached a research and development cooperation and licensing agreement with Roche .
It will use its RNA editing technology platform RNAfix and AAVid technology platform to develop gene therapies for the treatment of Alzheimer's disease, Parkinson's disease and rare diseases .
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Broad Institute issues newsletter this week
Time of Update: 2021-09-13
Researchers hope that this discovery published in "Nature Human Behaviour" will provide a new way to prevent and treat complex metabolic diseases .
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How to keep the brain awake?
Time of Update: 2021-09-13
The research team led by Tsukuba used a technique in their latest work to directly visualize the movement of red blood cells in the brain capillaries (the place where nutrients and waste are exchanged between brain cells and blood) in mice in waking and sleeping states.
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Peking University researchers report the discovery of a new potential receptor for the new coronavirus
Time of Update: 2021-09-13
For SARS-CoV-2 entry research paper, this study found a number of potential new cells that mediate SARS-CoV-2 invasion through genome-wide gain-of-function screening based on the CRISPR activation (CRISPRa) system Receptor .
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Cholesterol may cause breast cancer cell therapy to fail
Time of Update: 2021-09-13
In these in vivo studies, tumors proliferate in mice without exogenous 27HC, which indicates that the observed increase in tumorigenicity is not the result of the direct action of 27HC, but the cell's resistance to the anti-proliferative effects of 27HC .
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CRISPR gene editing in the brain to treat Alzheimer's disease shows potential
Time of Update: 2021-09-13
In the FAD mouse model, the researchers found that after receiving a one-time gene editing therapy for 6 months, the amyloid deposits in the brains of the treated mice were significantly lower than those in the control group .
Reference materials:[1] HKUST Scientists Develop Genome-editing Strategy for Potential Alzheimer's Disease Therapy.
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Nature: The largest single-cell whole-genome analysis to date
Time of Update: 2021-09-13
The researchers examined the genomic scars of each individual in order to reconstruct their early embryonic cell dynamics .
After the completion of the 20-year Human Genome Project, the development of genetic technology, to a certain extent, we are now able to accurately identify mutations in the single-cell genome.
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The discovery of the "Achilles' heel" of cancer cells can help develop new therapies?
Time of Update: 2021-09-13
Discovery of the "Achilles Heel" of cancer cellsHelps develop new therapies that limit the development of solid tumorsScience and Technology Daily, Beijing, August 29 (intern reporter Zhang Jiaxin) Researchers from the University of British Columbia School of Medicine and the Cancer Institute of British Columbia have discovered the weakness of a key enzyme called carbonic anhydrase IX (CAIX).
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Science recently released the new research results of the protein science research team of the Huazhong Agricultural University of Science and Technology
Time of Update: 2021-09-13
Nanhu News Network (Reporter Wang Qiang) In the early morning of August 27, 2021, Beijing time, Professor Yin Ping's research team from the Hubei Hongshan Laboratory, the State Key Laboratory of Crop Genetic Improvement and the School of Life Science and Technology published a topic online in Science A research paper on "Structural insight into the SAM-mediated assembly of mitochondrial TOM core complex", revealing the molecular mechanism of the assembly of the mitochondrial outer membrane TOM translocase complex .
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How to produce protein at the correct rate?
Time of Update: 2021-09-13
During the synthesis process, small condensates of RNA and protein appear in the cell, and its function is to slow down the rate of ribosome production .
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Nature: Hidden bacterial hairs power the "grid" in nature
Time of Update: 2021-09-13
Scientists are seeking to use this natural grid to generate electricity, produce new biofuels, and even self-repair electronic components .
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Reduce the risk of hospitalization and death by 21%
Time of Update: 2021-09-13
The trial reached its composite primary endpoint, that is, in adult patients with preserved ejection fraction heart failure (HFpEF), empagliflozin reduced the relative risk of cardiovascular death or hospitalization for heart failure by 21% compared with placebo .
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The sense of smell affects our choice of food, and in turn, what we eat also affects our sense of smell
Time of Update: 2021-09-13
"Pizza and cinnamonTo conduct this research, the research team developed a new task that asked participants to smell a mixture of food and non-food odors ("pizza and pine" or "cinnamon bun and cedar"-"a good match" And different smells) .
