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Effective mixed backbone antisense oligonucleotides inhibit the expression of mutant C9orf72
Time of Update: 2022-01-10
Using C9-ALS/FTD patient-derived cells and C9ORF72 BAC transgenic mice, we generated and optimized antisense oligonucleotides (ASOs), which can selectively attenuate the expression of G4C2 repeat transcripts and effectively Inhibit the level of poly (GP) dipeptide in the tissue .
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Mitochondrial C5aR1 activity in macrophages controls IL-1β production in aseptic inflammation
Time of Update: 2022-01-10
It is proved that the complement protein C5a sends a signal on the mitochondrial membrane through its receptor C5aR1 to control the production of IL-1β in response to the uptake of cholesterol crystals (CC) .
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Science: High-fiber diet can improve immunotherapy for patients with melanoma
Time of Update: 2022-01-10
According to a latest large-scale international collaborative study, when patients with melanoma receive immunotherapy, if their diet is rich in fiber, their immune system is more likely to kill cancer cells and produce a better response to the therapy .
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Li Xiaoliang's laboratory published a paper in JOURNAL OF VIROLOGY
Time of Update: 2022-01-10
078 )Authors: Xu, Jidong ; Mao, Junyong ; Han, Xiao ; Shi, Fushan ; Gao, Qin ; Wang, Tingjun ; Zhang, Zhenning ; Shan, Ying ; Fang, Weihuan ; Li, Xiaoliang* ()Source publication: JOURNAL OF VIROLOGYVolume 95, Issue 18, Literature Number e00853-21DOI10.
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The way to improve eye health is through the intestines?
Time of Update: 2022-01-10
After completing the National Institutes of Health (NIH) "Clinical Scientist Research Guidance Career Development Award", Lin became the first recipient of the Ohio State University School of Medicine "Physician-Scientist Transitional Support Award" .
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Nature's new achievement solves ten-year mystery and analyzes the structure of key proteins in Parkinson's disease
Time of Update: 2022-01-10
Zhong Yan Gan said: “An important discovery of ours is that PINK1 forms a dimer, which is essential for initiating or activating proteins to perform their functions .
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In experimental models, CBD can reduce the size of glioblastoma and support the environment
Time of Update: 2022-01-10
They found that CBD seems to be good at changing the tumor’s ecosystem or supporting the tumor’s microenvironment, including restoring inflammation levels, rather than protecting glioblastoma, which may make it a safe, effective and novel adjuvant treatment for these patients .
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Nature: No more flu shots every year?
Time of Update: 2022-01-10
Researchers have designed a more versatile experimental flu vaccine that stimulates the body to produce antibodies against HA's hard-to-change stem, which stretches like a stem between the influenza virus particles and the HA head .
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Chen Lingling's group discovered the immunogenic mechanism and potential applications of in vitro synthesis of circular RNA
Time of Update: 2022-01-10
Through in-depth comparison and analysis of the characteristics of different methods of in vitro synthesis of circular RNA, the study clarified the immunogenicity of in vitro synthesis of circular RNA and the molecular mechanism, and found that circular RNA with no immunogenicity and double-stranded structure can effectively inhibit natural immunity The activation of factor PKR reveals the application potential of in vitro synthesized circular RNA for the treatment of autoimmune diseases related to abnormal activation of PKR .
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Zheng Junke's research group from Shanghai Jiaotong University School of Basic Medicine published new results in Blood that bone marrow microenvironment components maintain the stemness of hematopoietic stem cells
Time of Update: 2022-01-10
Diagram of the working mode of ANGPTL2 derived from endothelial cells in bone marrow microenvironment regulating the stemness of HSCsResearcher Yu Zhuo from the Department of Pathophysiology of School of Basic Medical Sciences and PhD student Yang Wenqian are the co-corresponding authors of this paper .
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Professor Jianqing Xu’s team and collaborators reported that the combination of Lactobacillus plantarum strain and the new crown vaccine can significantly improve and maintain the immune response against the new crown after vaccination
Time of Update: 2022-01-10
<> </> Vaccination of the new coronavirus (SARS-CoV-2) vaccine is a key means to prevent and block the spread of the new coronavirus . Numerous studies at home and abroad have shown that the serum a
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Li Zhihuan, Hua Hui’s research group and collaborators from the School of Physics observed the new nuclide 18Mg outside the proton drip line for the first time and found new evidence that the magic number of N=8 disappeared
Time of Update: 2022-01-10
Words for Java 18. 9" >Associate Professor Li Zhihuan and Professor Hua Hui of the Department of Technical Physics and the State Key Laboratory of Nuclear Physics and Nuclear Technology, Peking Univer
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Human brain microglia methylation map
Time of Update: 2022-01-09
Researchers isolated microglia from the post-mortem brain tissues of 22 donors of different ages, including 1 patient with schizophrenia, 13 patients with mood disorders, and 8 people with no mental disorders extracted from 4 brain regions Control group .
Unsurprisingly, microglia display DNA methylation characteristics that differ from other cells in the central nervous system .
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A new study discovers previously unnoticed damage mechanisms from radioactive radiation
Time of Update: 2022-01-09
Excess energy causes Coulomb explosionThe DNA double helix structure of the genome is similar to a rope ladder composed of nucleic acid base pairs .
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"Science" supplemented with dietary fiber can strengthen your immune system and benefit cancer treatment
Time of Update: 2022-01-09
Morgun and collaborators studied hundreds of melanoma patients and analyzed their gut microbiota, eating habits, probiotic use, disease characteristics, and treatment results .
Morgun said: "We have found that the use of dietary fiber and probiotics can affect the gut microbiota, which is related to different ICB results .
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OptoMYPT: A new tool that uses focused light to reduce cell contractility
Time of Update: 2022-01-09
Blue light irradiation induces the translocation of SspB-PP1BD and endogenous PP1c from the cytoplasm to the membrane, resulting in inactivation of myosin near the membrane .
Blue light irradiation induces the translocation of SspB-PP1BD from the cytoplasm to the membrane by binding to iLID, resulting in co-recruitment of endogenous PP1c to the membrane .
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A common risk factor for Alzheimer's disease may be severe cerebrovascular disease
Time of Update: 2022-01-09
Now, a research team at the University of Helsinki and Helsinki University Hospital (HUS) has studied the link between the APOE4 allele and the severity of COVID-19 in the Finnish population .
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At the forefront of the battle, what makes T cells "immortal"?
Time of Update: 2022-01-09
Researchers at the University of Basel have now discovered a previously unknown signaling pathway that is essential for T cell survival .
They have further discovered an unknown coronin 1 driven signaling pathway that regulates T cell survival.
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Cultivate intestinal "organoids" in the laboratory to study why bats coexist with viruses but do not get sick
Time of Update: 2022-01-09
Intestinal organ of a round leaf bat Researchers are trying to explain why bats can be infected with many viruses, but never get a disease, such as COVID-19, which can help us reduce the chance that infectious diseases threaten humans .
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Russian scientists have discovered biomarkers of long-term post-traumatic stress disorder
Time of Update: 2022-01-09
In the research work of post-traumatic stress disorder, the representatives of the School of Medical Biology of Suzhou Medical University have reached a new level .
