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In the central nervous system, microglia play a key role in development, aging, brain homeostasis, and pathology
This research was published in "Biological Psychiatry" published by Elsevier
Microglia, the brain's own immune cells, were once considered to be a homogeneous population, either "activated" or "inactivated", with pro-inflammatory or neuroprotective effects
Dr.
DNA methylation is the main form of epigenetic regulation, which determines the mode of genes being turned on or off over time in different environments
Researchers isolated microglia from the post-mortem brain tissues of 22 donors of different ages, including 1 patient with schizophrenia, 13 patients with mood disorders, and 8 people with no mental disorders extracted from 4 brain regions Control group
Unsurprisingly, microglia display DNA methylation characteristics that differ from other cells in the central nervous system
"Biological Psychiatry" editor John Krystal said of this work: "These promising data show that in the biology of depression, the key immune cells of the brain-the pathology of microglia
Magazine
Biological Psychiatry
DOI
10.
Methodological research
Experimental Study
Subject of research
cell
Article title
Contribution of age, brain region, mood disorder pathology, and interindividual factors on the methylome of human microglia
