-
Nature publishes a "truly useful" cell atlas: containing more than 300 types of protein kinases found in human cells
Time of Update: 2023-02-01
Original:An atlas of substrate specificities for the human serine/threonine kinome Protein kinase, the most important class of enzymes in humans, is a signaling molecule that regulates almost all cellular activities, including growth, cell division, and metabolism.
-
Cell Shanghai Institute of Medicine collaborated to elucidate the molecular mechanism of action between the opioid receptor family and the endorphin system
Time of Update: 2023-02-01
The picture shows a brain blooming with poppies, a great source of opioid analgesics. A frog on the poppy indicates that dervanins from the surface of the frog's skin were used in this study. On the
-
The final exam results are announced, not only the quality of the results, but also the expectation that expectations may lead to anxiety
Time of Update: 2023-02-01
Individual differences in naturalistic learning link negative emotionality to the development of anxiety Aaron Heller is an associate professor of psychology and director of the Division of Cognitive and Behavioral Neuroscience at the University of MiamiSource: University of MiamiHow we learn from the false expectations we face in the real world varies from person to person.
-
New ways to treat olfactory loss in COVID-19
Time of Update: 2023-02-01
Now, Patel's team has tested a new treatment to treat the long-term loss of smell associated with COVID-19 by injecting platelet-rich plasma extracted from the patient's own blood.
-
Chinese scholars have found that the condensed matter of biological macromolecules can regulate the plasticity of spindle microtubules
Time of Update: 2023-02-01
Figure Schematic diagram of EB1 protein phase separation regulating cell division spindle microtubule plasticity With the support of the National Natural Science Foundation of China (grant numbers: 32090040, 91854203, 31621002, 21922706), Yao Xuebiao's research group and collaborators of the University of Science and Technology of China carried out research to clarify the physicochemical mechanism of phase separation of end-binding protein (EB1 protein) to regulate the plasticity of spindle microtubules in cell division.
-
The gut microbiome is not only an influencing factor in Parkinson's disease, but also the center of its onset
Time of Update: 2023-02-01
The researchers employed metagenomics to analyze genetic material recovered directly from the fecal microbiome of Parkinson's disease patients and neurohealth controls.
The researchers employed metagenomics to analyze genetic material recovered directly from the fecal microbiome of Parkinson's disease patients and neurohealth controls.
-
The new drug combination could be effective in treating often fatal childhood brain tumors
Time of Update: 2023-02-01
Researchers at the University of Colorado's Anschutz School of Medicine have discovered a combination of drugs that may provide a better prognosis for children diagnosed with MYC enlarged into medulloblastoma, a commonly fatal brain cancer.
-
The EMBO Journal: Revealing a novel mechanism by which PML nucleosomes recruit TRIM33 to regulate gene transcription in mouse embryonic stem cells
Time of Update: 2023-02-01
Studies have shown that TRIM33, a member of the TRIM family, is a key member of the TGF-β signaling pathway, regulating the transcription of relevant marker genes during the differentiation of mouse embryonic stem cells into the mesoderm.
-
Nature sub-journal: Previously unknown function of immune cells - T cell void
Time of Update: 2023-02-01
Study leader Christina Zielinski explains: "We found a cytokine in Th17 cells, a subset of T helper cells, which was previously thought to be part of the innate immune system.
-
Science: Gut bacteria affect brain health
Time of Update: 2023-02-01
The study, conducted in mice, found that gut bacteria (in part by producing compounds such as short-chain fatty acids) influence the behavior of immune cells throughout the body, including those in the brain, which damage brain tissue and exacerbate neurodegeneration in diseases such as Alzheimer's disease.
-
Research Grant: How Mutations Help Pancreatic Cancer Grow
Time of Update: 2023-02-01
Patra has studied a number of genetic abnormalities associated with pancreatic cancer, including a gene called GNAS.
Patra said he is very excited about the future of the project and believes that the environment of the cancer center, UC School of Medicine and the research community is key to his success.
-
A human health trajectory tracking framework using transfer learning based on gut microbial community data
Time of Update: 2023-02-01
In January 2023, the team of Professor Ning Kang of the Department of Systems Biology and Bioinformatics, School of Life Sciences, Huazhong University of Science and Technology, published a report entitled "Tracing human life trajectory using gut microbial communities by context-aware" in the internationally authoritative academic journal Briefings in Bioinformatics Deep Learning" proposes a human health trajectory tracking framework based on intestinal microbial community data using transfer learning, which initially solves the problem of age-dependent human health status diagnosis.
-
Due to manufacturing issues, the FDA delayed approval of topical gene therapy B-VEC
Time of Update: 2023-02-01
“ Krystal Biotech announced that the FDA has decided to postpone the PDUFA date for the Biologics License Application (BLA) for B-VEC for the treatment of dystrophic epidermolysis bullosa to May 19, 2023, following receipt of its manufacturing information document submitted on December 20, 2022, and recommends that instruction manual labeling discussions be held no later than April 20, 2023.
-
Chinese scholars have made progress in the research of aging mechanism and intervention
Time of Update: 2023-02-01
, blocking ERV transcription, reverse transcription, viral cascade infection and other processes, thereby delaying the aging of cells, tissues and even systems (Figure。This study systematically revealed that aging-induced resurrection of endogenous retrovirus (AIR-ERV) can be used as the cause and marker of aging in cells, organs and even the body, providing ideas for the evaluation and intervention of aging-related diseases.
-
The Yichengji research group in the School of Life Sciences has developed a new RNA editing technology RESTART
Time of Update: 2023-02-01
In addition, RESTART technology will also promote research in the field of pseudouridine modification, providing favorable tools for basic research in this field and the treatment of nonsense mutational diseases.
-
Nature's latest research finds weaknesses in the coronavirus!
Time of Update: 2023-02-01
”In a safety lab at Boston University's National Laboratory for Emerging Infectious Diseases (NEIDL), researchers first studied the virus's spike protein, a molecule that helps SARS-CoV-2 invade cells and start infections, and is also used in most vaccines.
-
Chinese scholars put forward new ideas that are stimulating noise
Time of Update: 2023-02-01
Figure 1 The image recognition accuracy "counterintuitively" shows the phenomenon of "first increase and then decrease" with the increase of image noise intensity Figure 2 Application example of posi
-
Neuron: "Uncertain areas" in the brain affect its ability to form new memories
Time of Update: 2023-02-01
But how do past events and experiences leave their mark there?The latest research has found that a rarely studied area of the brain, known as the "uncertainty zone" or "uncertainty zone," communicates with the neocortex in an unconventional way to quickly control memory formation.
-
Researchers construct ionizable iron nanoadjuvant for personalized tumor vaccine treatment
Time of Update: 2023-02-01
Ionizable iron nanoadjuvants represent a powerful and universal vaccine delivery platform, which can improve the efficiency of tumor antigen cross-presentation and T lymphocyte activation, and provide a new strategy for personalized tumor vaccine treatment.
-
A mysterious form of childhood epilepsy that causes the disease
Time of Update: 2023-02-01
The article, published in the January 12, 2023 issue of Nature Genetics, researchers at the UC San Diego School of Medicine and the Reddy Children's Genomic Medicine Institute, in collaboration with an international consortium of more than 20 children's hospitals worldwide, report a major breakthrough in understanding the genetic causes of MCD.
