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Researchers at the University of Colorado have discovered a new way to prevent heart fibrosis
Time of Update: 2023-02-02
”Unique inhibitorsThe CU study, published today in the American Heart Association's Journal of Circular Research, shows that compound SW033291 slows fibrosis by inhibiting the action of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme that degrades eicosanoids, lipid-signaling molecules that help prevent fibrosis.
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To solve a mystery that has puzzled biochemists for decades, scientists reconstruct an "ancestral enzyme"
Time of Update: 2023-02-02
The team reconstructed an ancestral enzyme by searching the database for the corresponding modern enzyme, calculated the original sequence using the obtained sequence, and introduced the corresponding gene sequence into the laboratory bacteria to produce the desired protein.
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Chem Eur J Shanghai Institute of Medicine conducted re-research on the chemical composition of Meat Mushroom soft coral
Time of Update: 2023-02-02
202203487 Team introduction Founded in 2000, Guo Yuewei's research group of Shanghai Institute of Materia Medica, has long been committed to the research of invertebrate chemistry, chemical ecology and biological activity/druggability in the South China Sea, especially in the field of chemical composition of soft corals in the South China Sea, and has achieved a series of research results.
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Xiao Xiang's team from Shanghai Jiaotong University and Hong Liang's team applied high-throughput protein structure groups to reveal the metabolic characteristics of the common ancestor of deep-sea hydrothermal archaea bacteria
Time of Update: 2023-02-02
Recently, Xiao Xiang's team, School of Life Science and Technology/State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, and Hong Liang's team from the Academy of Natural Scien
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Xie Wuxiang's team at the Clinical Research Institute combined artificial intelligence technology and fundus photo information to identify high-risk groups of dementia
Time of Update: 2023-02-02
Based on the above research background, Xie Wuxiang's research team cooperated with a number of studies to collect fundus photos and health-related data of 271,864 physical examination participants in 19 provinces (cities) across the country, and randomly divided them into development sets (95 %) and internal validation sets (5%), using convolutional neural network technology to develop artificial intelligence algorithms to estimate CAIDE dementia risk scores and in an independent external cohort (20,690 medical examination participants).
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The immune system's monitoring of cancer itself can induce metabolic adaptations in early tumor cells
Time of Update: 2023-02-02
" ” Ping-Chih HoSource: Ludwig Cancer Research CenterA study by the Ludwig Cancer Institute found that the immune system's monitoring of cancer itself can induce metabolic adaptations in early-stage tumor cells, while promoting their growth and enabling them to suppress deadly immune responses.
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Feng Xinhua's team revealed the role and molecular mechanism of HERC3 in promoting YAP/TAZ protein stability and tumorigenesis and development
Time of Update: 2023-02-02
The role and molecular mechanism of HERC3 in promoting YAP/TAZ protein stability and tumorigenesis and its molecular mechanismYuan Bo, a young researcher in Feng Xinhua Laboratory, Liu Jinquan, a postdoctoral fellow (currently working in the First Affiliated Hospital of Zhejiang University), and Shi Aiping, a professor at Bethune Hospital affiliated to Jilin University, are co-first authors of the paper, and Feng Xinhua and Zhao Bin are co-corresponding authors.
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New crown immunity "son preference"? Nature: The new crown virus changes the immune system, and men are more likely to trigger excessive immune responses!
Time of Update: 2023-02-02
On January 4, 2023, researchers from the National Institute of Allergy and Infectious Diseases and Yale University published a research paper titled "Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19" in the top international journal Nature 。 Studies have found that the long-term effects of new coronavirus infection on the immune system are related to the sex of the individual, and that viral infection affects the basic immune status of humans, which in turn affects future immune responses.
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Chinese scholars have made progress in the research of Chinese-brain connectome and its big data resources
Time of Update: 2023-02-02
Figure: Comparison of Chinese and Western brain function activation maps With the funding of the National Natural Science Foundation of China (grant numbers: 81790650, 81727808), Professor Gao Jiahong's team of Peking University has made progress in the research of Chinese brain connectome and its big data resources 。 The findings, titled "Increasing diversity in Chinese connectomics with the Chinese Human Connectome Project," were published online in Nature on December 19, 2022.
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Itchy eyes, runny nose? Climate change may be to blame
Time of Update: 2023-02-02
A team of researchers at Rutgers University's Institute for Environmental and Occupational Health Sciences used computer modeling to study the effects of climate change on the distribution of pollen from native U.
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Molecular Psychiatry: Expression of immune-related genes in the brains of autistic patients
Time of Update: 2023-02-02
According to a new study of thousands of postmortem brain samples, genes involved in immune system function have atypical expression patterns in the brains of people with certain neurological and psychiatric disorders, including autism.
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A new way to explore plant-microbial interactions
Time of Update: 2023-02-02
In the three-year project, Babnigg and his colleagues at Argonne, the University of Chicago, and the Department of Energy's Joint Genomics Institute plan to develop a new imaging technique that uses engineered plant growth to promote bacteria as biosensors.
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The first amputated human limb model for studying human tissue imaging probes
Time of Update: 2023-02-02
The team believes that human limb models can in the future be used not only to study and select other fluorescent agents, but also to study peripheral diseases and pathological features of tissues under controlled conditions.
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Brain: A new biomarker may help detect Alzheimer's disease neurodegeneration in the blood
Time of Update: 2023-02-02
Recently, a research report entitled "Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration" published in the international journal Brain, scientists from the University of Gothenburg and other institutions have developed a new detection technology through research.
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The first to mine the fungal genome using multiple base editing
Time of Update: 2023-02-02
Xue Sherry Gao, a chemical and biomolecular engineer at Rice University, and his collaborators used a method to simultaneously modify multiple sites in the fungal genome, tricking the fungi into revealing their best-kept secrets, speeding up the pace of new drug discovery.
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The mRNA monkeypox vaccine is doing well, but it may not be on the market
Time of Update: 2023-02-02
In May last year, when Moderna announced the development of an mRNA monkeypox vaccine, the monkeypox epidemic in the United States was just beginning, with an average of two new cases reported per day.
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Science discovers previously unknown components of the brain: the platforms on which immune cells monitor brain infections and inflammation
Time of Update: 2023-02-02
A new study describes a new anatomical structure in the brain called SLYM, short for Subarachnoidal lymphoaticlike membrane, which acts as a barrier and platform for immune cells to monitor the brainSource: University of CopenhagenFrom the complexity of neural networks to basic biological functions and structures, we still don't know enough about the human brain.
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Weiling Sun's research group in the School of Environment revealed the effects of micro/nanoplastics and azithromycin on cyanobacterial photosynthetic carbon sequestration under single and composite pollution conditions
Time of Update: 2023-02-02
Screenshot of the coverThis work found the antagonistic effect between micro/nanoplastics and azithromycin that decreases with the increase of plastic particle size, revealing that nanoplastics mainly adversely affect algal cells by damaging the integrity of cell membranes, while microplastics mainly affect the photosynthetic carbon sequestration of algae through shading effect.
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Nature stops aging – strengthens immune cells and improves brain waste removal
Time of Update: 2023-02-02
In this study, we treated aged mice with a molecule that activates senescent immune cells, which plays a role in improving brain fluid flow and waste removal.
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PNAS: A cellular mechanism for improving physical fitness through exercise training
Time of Update: 2023-02-02
The researchers recorded wild-type Caenorhabditis elegans swimming or crawling, observing typical age-related declines in the animals' physical health within 15 days of reaching adulthood.
The researchers recorded wild-type Caenorhabditis elegans swimming or crawling, observing typical age-related declines in the animals' physical health within 15 days of reaching adulthood.
