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A new technique to reveal hidden genomes
Time of Update: 2022-09-09
Computational biologist Dr Sonia Chothani, a Duke-NUS Cardiovascular and Metabolic Disease (CVMD) program researcher and lead author of the study, explained: "We have a large portion of the 2% of the genome that is known to encode proteins.
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Science Advances: Protein structure is not static
Time of Update: 2022-09-09
This work underscores the power of combining genomic data and structural biology approaches to study one of the most important questions in biology and draws some unexpected conclusionsArticle titleStructural plasticity enables evolution and innovation of RuBisCO assemblies Pictured: Albert Lui (left) and Patrick Shih show how they studied the structure and evolution of rubisco, an enzyme used by plants to produce sugars from carbon dioxide, in Koshland Hall, University of California, Berkeley.
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Shanghai Jiaotong University Chen Gongyou's team revealed a new mechanism for S. striae to overcome stomatal immunity in rice
Time of Update: 2022-09-09
This study revealed for the first time the pathogenic mechanism of type III effector proteins targeting lipids, expanded the knowledge in the field of plant target research, and provided new ideas for plant disease prevention and control .
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Autoimmune diseases increase the risk of cardiovascular disease
Time of Update: 2022-09-09
In a large epidemiological study from the University of Leuven, researchers showed that patients with autoimmune diseases had a higher risk of developing cardiovascular disease than individuals without autoimmune diseases.
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Nature Sub-Journal: New insights into organ development help fight cancer
Time of Update: 2022-09-09
Image credit: Courtesy Zang lab Dr. Chongzhi Zang of UVA and his collaborators have revealed a key process that determines the formation of our digestive tract, lungs and liver, a finding that may have important implications for our understanding of cancer.
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A genetic evolutionary mechanism that produces mucin function
Time of Update: 2022-09-09
Results and discussionMultiple instances of SCPP site evolution from de novo mucinTo establish the basis for studying the evolution of mucin, we constructed a simple but conservative bioinformatics approach that identifies potential mucin genes in a given genome by searching for available gene annotations, and confirms mucin function by validating proline(P), threonine (T) rich exon repeats, as well as serine amino acids.
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Explore how molecular motors convert chemical energy into mechanical work.
Time of Update: 2022-09-09
References: Mechanism of AAA+ ATPase-mediated RuvAB-Holliday junction branch migration Molecular motors are complex devices made up of many different parts that consume energy to perform various cellular activities.
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During bacterial meningitis, the brain housekeeper fails?
Time of Update: 2022-09-09
”Published: Dysfunctional glymphatic system with disrupted aquaporin-4 expression pattern on astrocytes causes bacterial product accumulation in the CSF during pneumococcal meningitis Bacterial meningitis is a life-threatening brain infection that causes long-term nerve damage to many survivors.
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Literature sharing Single-cell TCR sequencing: Analyzing immunohistocologic characteristics of renal cell carcinoma
Time of Update: 2022-09-09
Preface:T cells are an important component of the acquired immune response, and their surface receptors (T cell receptors) (TCRs) act to recognize antigen molecules. NGS is the mainstream technology f
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Cotton team reveals new mechanism of cotton callus fate regulation
Time of Update: 2022-09-09
Nanhu News (Correspondent Sun Weinan) Recently, the research results of the cotton genetic improvement innovation team of our school were published in The Plant Cell with the title of "GhTCE1-GhTCEE1 dimers regulate transcriptional reprogramming during wound-induced callus formation in cotton" .
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Mermaid prototype 'Dugong' confirmed to be extinct in China
Time of Update: 2022-09-09
The dugong (rú gèn) is a first-class protected animal in China and was once listed as one of the endangered species .
The dugong (rú gèn) is a first-class protected animal in China and was once listed as one of the endangered species .
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Nitric oxide "scavengers" to target triple-negative breast cancer
Time of Update: 2022-09-09
"Nitric oxide is one of the major free radicals produced by tumor tissue," Amir explains, "at a certain concentration, it plays an important role in breast cancer progression by inducing cancer cells to spread to other parts of the body.
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The molecular mechanisms underlying the spatial mapping of the brain in Nature
Time of Update: 2022-09-09
The new study, conducted in mice, published Aug. 24 in the journal Nature, confirms that a gene called Fos plays a key role in spatial mapping, helping the brain use specialized navigation cells to form and maintain stable characterization of the environment.
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New ways to detect electrical signals in the brain may be the key to better treatments for epilepsy and schizophrenia
Time of Update: 2022-09-09
Researchers at Aston University are exploring new ways to "listen" and record electrical signals from brain cells, which could help treat the disease.
Researchers at Aston University are exploring new ways to "listen" and record electrical signals from brain cells, which could help treat the disease.
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Building knowledge: Chinese scholar Science's latest article, developing new chromosome editing technology to create new karyotype mice
Time of Update: 2022-09-09
, Ltd. Schematic diagram of chromosome connection and FISH test resultsChromosome-connected mouse "Xiaozhu" has a unique karyotype Original link: On August 26, 2022, Science magazine published a research paper titled A sustainable mouse karyotype created by programmed chromosome fusion, which was jointly completed by the team of Researcher Li Wei and Researcher Zhou Qi from the Institute of Zoology, Chinese Academy of Sciences and Beijing Institute of Stem Cell and Regenerative Medicine.
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Zhang Xinjun's team from the School of Life, Huazhong University of Science and Technology discovered that the small G protein RAB21 regulates autophagy and energy homeostasis
Time of Update: 2022-09-09
2114271 On August 21, 2022, the team of Professor Zhang Xinjun from the School of Life Science and Technology of Huazhong University of Science and Technology published the latest research results online entitled "RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1" in "Autophagy" magazine.
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The team of Hou Tingjun of Zhejiang University School of Pharmacy reported in Research an AI-based covalently targetable cysteine prediction method...
Time of Update: 2022-09-09
In July 2022, the team of Professor Hou Tingjun/Pan Peichen of the School of Pharmacy, Zhejiang University published a research paper titled "Proteome-Wide Profiling of the Covalent-Druggable Cysteines with a Structure-Based Deep Graph Learning Network" online in the Research magazine, proposing a new A graph representation-based deep learning method DeepCoSI is used for the prediction of covalent drug binding sites .
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BIOPIC Tang Fuchou's research group and collaborators systematically explore the effect of spindle replacement technology on early human embryonic development
Time of Update: 2022-09-09
Figure 1 Comparative analysis of transcriptomes of spindle-replaced blastocysts and ICSI control blastocystsWe further inferred the sex of each embryo based on the expression levels of sex-linked genes and found that sex ratio was a confounding factor in the differentially expressed gene analysis (Fig. 2), i.
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Researchers discover new molecular target for nonalcoholic steatohepatitis
Time of Update: 2022-09-09
article titlePromotion of nonalcoholic steatohepatitis by RNA N 6-methyladenosine reader IGF2BP2 in mice Figure: IGF2BP2 overexpression leads to liver steatosis (left), inflammation (middle), and hepatocyte apoptosis (right) in mice .
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The incidence of liver disease in children rises rapidly, and The Lancet emphasizes the root causes
Time of Update: 2022-09-09
"These findings could provide more effective early prevention and intervention strategies to address the current non-alcoholic fatty liver epidemic," said Dr. Vishal Midya, a member of the Mount Sinai Exposure Institute at the Icahn School of Medicine, The Department of Environmental Medicine and Public Health, and a postdoctoral researcher.
