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A new discovery from the University of Virginia School of Medicine sheds light on how our digestive tract, lungs and liver are formed, a discovery that could have important implications
During mammalian development, the stomach, colon, intestine, pancreas, liver, lungs, esophagus, pharynx (throat), and thyroid are all formed
Dr.
"Gut development is a fascinating dynamic process from which we can learn how the same genome creates many different types of cells in different organs," said
Understand organ development
Zang and his colleagues, including collaborators led by Dr.
The team found that chromatin exhibits different dynamics in cells that become livers, for example, in
Later in the course of development, these interactions will further refine the emerging organs, for example, allowing the intestine to be subdivided into the large and small intestines
It is important
The researchers note that the "cell fate" error occurs in the early stages of pancreatic cancer, leading to precancerous lesions
"A better understanding of how genes work during organ development could give us insight into the underlying mechanisms by which many types of cancer occur," Zang said