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Explore how molecular motors convert chemical energy into mechanical work.

 Last Update: 2022-09-09
 Source: Internet
 Author: User

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Molecular motors are complex devices made up of many different parts that consume energy to perform various cellular activities

Now, a team of Thomas C.

They report in nature how the RuvAB branch migration complex converts chemical energy into mechanical work for DNA recombination and repair

The basic energy needed for this branch migration to occur comes from a molecular mechanism that scientists label as the RuvAB branch migration complex

Active branch migration excited by RubB AAA+ motor molecules is very rapid and highly

The scientist captured more than 10 million images

"We were able to visualize the seven different states of the motor and demonstrate how interrelated elements work

AAA+ motors are often used in other biological systems, such as protein transport, so a detailed model of this RuvB AAA+ motor can serve as a blueprint

Future work by marlovits' team will explore ways

References: Mechanism of AAA+ ATPase-mediated RuvAB-Holliday junction branch migration

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