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Mitochondrial DNA (mtDNA) mutations often cause severe inherited metabolic diseases, affecting the quality of life and even life safety of patients, and there is no cure yet
In order to systematically evaluate the impact of spindle replacement technology on human embryonic development, and determine whether spindle replacement technology has clinical translational value and safety, the team of Tang Fuqiu from the Biomedical Frontier Innovation Center (BIOPIC) of Peking University and the Seventh PLA General Hospital A research paper entitled "Single-cell multiomics analyses of spindle-transferred human embryos suggest a mostly normal embryonic development" was published online in Plos Biology on August 16, 2022, in cooperation with the Shangwei team of the Medical Center
1.
Figure 1 Comparative analysis of transcriptomes of spindle-replaced blastocysts and ICSI control blastocysts
We further inferred the sex of each embryo based on the expression levels of sex-linked genes and found that sex ratio was a confounding factor in the differentially expressed gene analysis (Fig.
Figure 2 Sex inference and sex-linked differential gene analysis of spindle-replaced blastocysts and ICSI control blastocysts
2.
Fig.
3.
Figure 4 Copy number variation analysis of spindle-replaced blastocysts and ICSI control blastocysts
4.
Figure 5 Integrative analysis of transcriptome and DNA methylome
Taken together, this study provides the first comprehensive and systematic single-cell multi-omics analysis of spindle replacement technology, demonstrating that the technology is useful in transcriptome, DNA methylome, and genome (copy number variation) levels.
Figure 6 The research framework and main findings of the paper
Qi Shuyue and Xue Xiaohui, doctoral students of Peking University, Wang Wei, postdoctoral fellow of the Seventh Medical Center of the PLA General Hospital, and Lu Zhuo of the New Hope Reproductive Medicine Center in New York are the co-first authors of the paper
