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CRISPR base editing technology can correct Hurler syndrome before birth
Time of Update: 2021-08-08
According to a report published in the journal Nature Communications by researchers from the University of Pennsylvania, they have now shown that in a mouse model, it is possible to use the gene editing system CRISPR to correct Hurler syndrome in mice before birth.
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CSA & TISC 2021 Professor Li Xiaogang Interview: Combined with non-statin lipid-lowering program to promote ischemic stroke lipid-lowering standards
Time of Update: 2021-08-08
Introduction At present, the secondary prevention of ischemic stroke in China has limited benefits based on the current treatment plan.
Yimaitong: At present, the effect of statins for lipid-lowering treatment is limited.
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The diagnosis and treatment of recurrent dizziness and vertigo is done in one article!
Time of Update: 2021-08-08
2 Diagnosis of recurrent dizziness and vertigo Professor Qi Xiaokun introduced that the diagnosis and differential diagnosis of recurrent dizziness and vertigo should consider factors such as the onset of disease, frequency of attacks, duration of symptoms, etc.
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Can thrombolysis in mild and wake-up strokes?
Time of Update: 2021-08-07
It included patients with acute ischemic stroke with a NIHSS score of 0-5 and non-obviously disabling from May 30, 2014 to December 20, 2016, in the United States 75 The hospitals were treated with alteplase and aspirin, and it was found that intravenous thrombolysis within 3 hours after the onset of mild non-disabling stroke did not improve the short-term prognosis and had a higher risk of symptomatic intracranial hemorrhage .
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This invisible "vascular stenosis" can cause cerebral infarction
Time of Update: 2021-08-07
Ling Yifeng from the Department of Neurology of Shanghai Huashan Hospital to lead us to start with the case and understand the multiple cerebral infarctions caused by small vessel disease step by step .
CADASIL: autosomal dominant cerebral artery disease with subcortical infarction and leukoencephalopathy; more common, early temporal pole involvement; NOTCH3 gene pathogenic mutation .
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Interview with Professor Wu Bo: Thoughts on bleeding transformation after intravenous thrombolysis CSA & TISC 2021
Time of Update: 2021-08-07
At the 7th Annual Conference of the Chinese Stroke Society and the Tiantan International Cerebrovascular Disease Conference (CSA & TISC 2021), Yimaitong was fortunate to interview Professor Wu Bo on the topic of hemorrhage transformation after intravenous thrombolysis.
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Courier Advances Phase 3 Trial of Alzheimer's Disease Antibody Therapy, Eli Lilly Reaches Strategic Cooperation
Time of Update: 2021-08-07
The randomized, double-blind, placebo-controlled Phase 3 clinical trial TRAILBLAZER-ALZ 3 will evaluate the Lilly's research antibody therapy donanemab to slow Alzheimer's in patients at risk of cognitive and functional decline associated with Alzheimer's disease The possibility of clinical progression of silent disease, regardless of whether the subject carries the APOE4 gene .
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Always want to eat spicy food when you lose weight?
Time of Update: 2021-08-07
In the experiment, the control of these neuronal activities is to simulate the information transmitted to the fan-shaped area of the brain by the different sense organs produced by the fruit fly when facing different foods .
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The latest guidelines for emergency analgesia evaluation and medication are very clear, and collect them quickly!
Time of Update: 2021-08-07
Table 1: Common pain in emergency patients (organized from Professor Guo Wei's PPT) Analgesia and sedation are an important part of the treatment of emergency patients.
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Two-dimensional semiconductor transistors simulate synaptic behavior stimulated by drugs｜npj 2D Materials and Applications
Time of Update: 2021-08-07
The team used the excellent gate control ability and photosensitivity of the two-dimensional semiconductor material-indium selenide (InSe) to fabricate charge trap assisted transistor-type synaptic devices, and successfully simulated the synaptic plasticity after the action of drugs .
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Can stroke patients with atrial fibrillation be anticoagulated?
Time of Update: 2021-08-06
Figure 3: Chinese and foreign guidelines recommend antiplatelet therapy in the secondary prevention of patients with atrial fibrillation stroke (Professor Tu Yuan ppt) ■ Question 2: When should anticoagulation therapy be initiated?
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Nature Genetics, a multi-omics analysis of brain tissue in patients with Alzheimer's disease at single nucleus resolution
Time of Update: 2021-08-06
Next, the author used Monocle3 [2] to perform pseudo-time trajectory analysis on the integrated data of snATAC-seq and snRNA-seq in oligodendrocytes, microglia and astrocytes, and used variational loop automatic Encoders (recurrent variational Autoencoder, RVAE) [3] model gene expression and chromatin access dynamics to reveal the molecular mechanisms that drive the heterogeneity of glial cells in AD .
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Vascular risk stratification after spontaneous cerebral hemorrhage
Time of Update: 2021-08-06
Kim, MD in a pooled analysis of two cohorts of patients with massive cerebral hemorrhage Among them, lobar hemorrhage and atrial fibrillation increase the risk of recurrent cerebral hemorrhage or ischemic stroke .
8 cases per 100 patients-years, respectively), but the incidence of ischemic stroke is similar regardless of the location of cerebral hemorrhage (Respectively 1.
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The director of the Department of Neurology of Huashan Hospital makes a big strike!
Time of Update: 2021-08-06
Metz Medical WeChat video account [Neural New Frontiers] On July 21st, Director Zhang Junhai of Huashan Hospital Affiliated to Fudan University will broadcast the introduction and improvement of craniocerebral pathological imaging.
Come and scan the code and follow the new frontier video number of Neurology!
Daily updates, more exciting live broadcasts are waiting for you!
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Intracranial hemorrhage combined with renal insufficiency, intensive blood pressure reduction may be fatal!
Time of Update: 2021-08-06
The results of a post-hoc analysis of an open-label ATACH-2 trial involving nearly 1,000 ICH patients showed that patients with estimated glomerular filtration rate (eGFR) decreased after intensive antihypertensive treatment at a significantly higher risk of death and disability than patients with normal eGFR .
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Depression in adolescence, is it because of inflammation in childhood?
Time of Update: 2021-08-06
The researchers pointed out that if inflammation occurs during the critical time of brain development in the early childhood, it will have a profound impact on the microglia in the brain, making it more likely to be randomly activated by stress events during adolescent development .
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Diabetics are at risk of dementia, ADA: do not be afraid to do this
Time of Update: 2021-08-06
Many people may have realized that low blood sugar will affect the energy supply to the brain, but in fact not only low blood sugar will affect the brain, high blood sugar and the entire metabolic abnormality caused by diabetes will also affect the brain-leading to cognition Dysfunction, sleep disturbance and even increase the risk of dementia .
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Neuron: How can dangerous gas leaks be quickly sensed and trigger escape behavior?
Time of Update: 2021-08-06
On July 12, 2021, the joint research team of Frank Zufall, Saarland University, Germany, and Peter Mombaerts, Max Planck Institute, Germany, mice sense hydrogen sulfide dangerous gas signals through the B-type cells of the olfactory epithelium to trigger defensive behavior .
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Express significantly improves chronic diabetic pain, FDA approves spinal cord electrical stimulation system
Time of Update: 2021-08-06
▎ WuXi AppTec content team editor July 19, 2021, Nevro announced that its proprietary 10 kHZ spinal cord stimulation (SCS) "Senza" system has been approved by the US FDA for the treatment of painful diabetic neuropathy (PDN).
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Interview with Prof. Song Haiqing: Essentials of Recognition and Management of Cerebral Small Vessel Diseases CSA & TISC 2021
Time of Update: 2021-08-06
Initially we thought that cerebral microhemorrhage may be a very important imaging manifestation, but as the research continues, we have found that it may increase the additional risk of cerebrovascular disease treatment, especially the antithrombotic of ischemic stroke , Anticoagulation therapy, which may increase the risk of bleeding, and is highly related to the location, etiology, and number of microbleeding lesions .
