Diabetics are at risk of dementia, ADA: do not be afraid to do this

*It is only for medical professionals to read for reference.
Diabetes patients need to prevent Alzheimer's disease.
ADA teaches you to do it all with one stone.
The brain is the number one player in energy metabolism throughout the body.
Metabolic diseases and the brain are also inextricably linked
.

Many people may have realized that low blood sugar will affect the energy supply to the brain, but in fact not only low blood sugar will affect the brain, high blood sugar and the entire metabolic abnormality caused by diabetes will also affect the brain-leading to cognition Dysfunction, sleep disturbance and even increase the risk of dementia
.

 At this American Diabetes Association (ADA) annual meeting, two complete agendas were set up to discuss diabetes and brain health.
Professors from major universities and research institutions explained the impact of diabetes on the brain, and how to control and prevent it.
Related diseases
.

 Memory in decline? Can't sleep well? It may be related to poor blood sugar control.
Many patients with type 2 diabetes may have problems such as cognitive dysfunction, sleep disturbance, and memory loss at the same time, but often patients will blame these problems on a single neurological disease
.

In fact, these clinical symptoms may be secondary to diabetes itself, especially if the life>
.

 Professor Anna Marseglia from Karolinska Institutet in Sweden suggested that about 3% of dementia cases are "contributed" by diabetes
.

Regardless of the small proportion of 3%, the number of patients with dementia and diabetes in the world is already very large, and this data is still rising.
Among them, the growth trend of these two diseases in China is not optimistic.
This question must not be taken lightly
.

 Figure 1 Prediction of the number and increasing trend of dementia patients and diabetic patients From the perspective of diabetic patients, in fact, the risk is not limited to this mere 3%, but increased by 60%-130%
.

According to a meta-analysis of previous studies, the risk of Alzheimer’s disease in patients with type 2 diabetes is 1.
6 times the risk of disease in healthy people, while the risk of vascular dementia is even higher, reaching 2.
3 times—this is related to diabetes.
Related to vascular disease
.

 Figure 2 Compared with the risk of Alzheimer's disease and vascular dementia in patients with type 2 diabetes, dementia is finally diagnosed.
Cognitive dysfunction, changes in white matter and even changes in brain volume may occur first
.

Columbia University professor Jose A.
Luchsinger pointed out that these damages are mainly caused by poor blood sugar control and poor blood pressure control
.

 Professor Luchsinger also showed a relieved research result
.

In the past, it was suggested that patients with type 2 diabetes may be more likely to accumulate beta amyloid (Aβ) in the brain than healthy people, leading to an increased incidence of Alzheimer's disease
.

The results of Professor Luchsinger’s research show that patients with type 2 diabetes with normal neurological activity are not more likely to accumulate Aβ in their brains than patients with non-type 2 diabetes
.

 In the figure below, we can see that in patients with type 2 diabetes, the proportion of people with high Aβ in the brain is not very large (only 5.
1%), and there are slightly more people with moderate accumulation of Aβ in the brain than non-patients.
Aβ in the brain is There is almost no difference between the proportion of low-level patients and non-patients (49.
5%)
.

In other words, nearly half of patients with type 2 diabetes have very low levels of Aβ accumulation in the brain
.

Figure 3 The leftmost group of bars represents non-patients, the rightmost is diagnosed type 2 diabetes patients, and the green bars represent the proportion of the brain with a high degree of Aβ accumulation.
This is good news, because it means that there is no such uncontrollable physiology.
Factors to prevent us from controlling and preventing diseases
.

 Reduce blood pressure and control sugar with both hands, but also live an active life>
.

 It should be understood that nerve damage is difficult to reverse.
If a diabetic patient has already suffered nerve damage, what needs to be done is to stop the damage immediately or at least reduce the speed of the damage
.

Professor Luchsinger introduced the improvement of brain structure and the prevention of cognitive impairment by strengthening blood pressure and strengthening blood sugar
.

At the same time, long-term intensive life>
.

 As the study in the figure below suggests, under 8-12 years of life>
.

Figure 4 The intensive life>
.

It seems that by improving life>
.

 In fact, life>
.

Professor Anna Marseglia’s research pointed out that life>
.

 But the life>
.

 In Professor Marseglia’s research, life>
.

The higher the latter three, the more active they are considered
.

 Figure 5 The life>
.

 Figure 6 The statistical results of Professor Marseglia's life>
.

The combination of a poor life>
.

In addition, this study also found that brain volume and brain gray matter are also affected by life>
.

 Finally, Professor Marseglia pointed out that an active life>
.

 Global Connection, the speaker of the dialogue, what kind of physical exercise can prevent diabetics from dementia, can you talk specifically about it? Professor Anna Marseglia's research includes multiple dimensions.
The level of education before adulthood and the complexity of work after adulthood are all our objects of investigation
.

As far as physical exercise is concerned, it is actually included in the comprehensive concept of the three dimensions of lifelong cognitive activity, physical exercise level and social activity level of our survey subjects
.

In our questionnaire design, the measure of physical exercise is that if more than two high-intensity exercises per week (running, long-distance cycling, high-intensity aerobic, swimming, ball sports), we classify it as "high", We classify moderate-intensity exercises more than once a week as "medium", and classify them as "low" if even one exercise per week is not guaranteed
.

However, we have not conducted precise independent research on this factor, so the specific exercise or the amount required requires further clinical intervention research
.

At present, we can be sure that physical exercise will definitely help reduce the risk of dementia
.

Is the risk of dementia related to the course and complications of diabetes? Professor Anna Marseglia We did not observe the correlation between the age of the disease and dementia and decreased brain volume, but there is a correlation between blood sugar control level and decreased brain volume.
In patients with HbA1c higher than 6.
5%, cognitive impairment is more severe and dementia Progress is faster
.

In addition, cardiovascular complications have been shown in a Swedish cohort study, not only to increase the risk of dementia, but also to cause cognitive decline earlier
.

Source of this articleMedical Endocrine Channel Author of this articleJiang Feixiong Chief EditorCao Qian’s Copyright Statement This article is original, reprinting requires contact authorization -End-Submission/Reprint/Business Cooperation, please contact: pengsanmei@yxj.
org.
cn