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Study of Nervous System

The BMJ: Intervention effects of opioid dose reduction in chronic noncancer pain

 Time of Update: 2022-04-24

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guideIn a study published today in the top journal BMJ, researchers aimed to evaluate interventions to reduce long-term opioid therapy in patients with chronic noncancer pain, taking into account dose reduction and discontinuation, pain, function, quality of life , Efficacy of withdrawal symptoms, drug use, and adverse events .
npj Parkinsons Dis: Integrating 4 million clinical data in the UK, what are the characteristics of the incidence of Parkinson's?

 Time of Update: 2022-04-24

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Therefore, to determine changes in the incidence of PD in the UK, Olaitan Okunoye et al at UCL UK studied age-adjusted incidence of PD in the UK primary care database, using the same confirmation method over time, using several definitions to illustrate the diagnosis Pattern changes over time .
npj Parkinsons Dis: Parkinson's disease, the inflammasome facilitates the assessment of the condition

 Time of Update: 2022-04-24

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This link is intuitive because NLRP3 inflammasome activity can be triggered by germ-free cellular stress associated with neurodegenerative disease pathology, including cell death, mitochondrial stress, reactive oxygen species (ROS), and proteinaceous damage, including amyloid -β and α-synuclein aggregation .
Neurology: Long-term ECG monitoring (PCM) after stroke improves the detection rate of atrial fibrillation and starts the application of anticoagulant drugs. The long-term benefits of stroke prevention need to be further demonstrated!

 Time of Update: 2022-04-24

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Cardiac rhythm monitoring (PCM) ischemic stroke (IS) atrial fibrillation (AF) European society of cardiology (ESC) American Stroke Association/American Heart Association (ASA/AHA) transient ischemic attack (TIA)In the current systematic review and meta-analysis, we sought to assess the impact of PCM on secondary stroke prevention by analyzing data from randomized controlled clinical trials (RCTs) and observational studies available to date .
NEUROLOGY: Loneliness linked to increased risk of dementia

 Time of Update: 2022-04-24

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published a research article in NEUROLOGY entitled Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline, studying loneliness and 10-year all-cause dementia risk and early cognitive and neuroanatomy of ADRD susceptibility Associations between imaging markers . 0000000000200039Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline.
Age & Ageing: In 1 in 4 hospitalizations, recurrent delirium can increase dementia risk by 7.8 times!

 Time of Update: 2022-04-24

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Taken together, delirium increases the risk of future cognitive decline and dementia independent of disease severity and baseline cognitive performance, with more episodes associated with worse cognitive performance .
npj Parkinsons Dis: What inspires us about Parkinsons morbidity, prevalence and mortality across Norway?

 Time of Update: 2022-04-24

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In the current study, Brage Brakedal lamps at Haukeland University Hospital, Norway, used the Norwegian Drug Prescription Database (NorPD) to assess the incidence, prevalence and mortality of PD in the entire Norwegian population between 2004 and 2017 .
JCI: Children with complete IRF8 deficiency are susceptible to alveolar proteinosis and multiple infectious diseases

 Time of Update: 2022-04-24

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Autosomal recessive (AR) complete IRF8 deficiency, a severe congenital immunodeficiency (IEI), has been reported in three unrelated patients from Ireland, the United Kingdom, and China . These results are representative of two independent experimentsFigure 2 Peripheral blood leukocyte, hemoglobin, and platelet counts and functions .
BMJ: Attention!

 Time of Update: 2022-04-24

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To estimate the risk of ischemic stroke associated with the use of antidopaminergic drugs (ADA) , researchers from France conducted a case-time-control study . BMJ 2022;376:e066192 Risk of first ischaemic stroke and use of antidopaminergic antiemetics: nationwide case-time-control study.
Brain Shenzhen Children's Hospital: Genome sequencing is expected to become the preferred method for genetic testing of epilepsy children in my country

 Time of Update: 2022-04-24

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To assess the diagnostic value of genome sequencing for childhood epilepsy and provide genome sequencing-based insights into the molecular genetic mechanisms of epilepsy to help establish an accurate diagnosis, design appropriate treatments, and assist in genetic counseling, experts from Shenzhen Children's Hospital conducted a survey of 320 The genomes of two Chinese children with epilepsy were sequenced, and single-nucleotide variants and copy-number variants were interpreted in all samples, and the results were published in the journal Brain .
Neurology: Relationship between modified rankin scale and recovery phenotype in patients with upper extremity weakness after stroke

 Time of Update: 2022-04-24

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After the stroke trial confirmed the exact value of stroke, mRS was roughly associated with domain-specific outcomes, but it did not accurately distinguish differences between lesions and function, nor did it adequately capture meaningful clinical changes across lesions, ADL status, and mobility .
NEJM: Endovascular therapy combined with thrombolysis in patients with massive acute stroke

 Time of Update: 2022-04-24

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For acute stroke patients with large vessel occlusion with large infarct size, thrombolysis combined with endovascular therapy is more effective than thrombolysis alone in improving the prognosis of patients, but the risk of intracranial hemorrhage is increased .
Neurology: Statins may be mediated by lower risk of cerebral atherosclerosis and may reduce Parkinson's risk in adults!

 Time of Update: 2022-04-24

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research method:research method:The study, conducted in older adults, was clinically tested annually for four Parkinson's symptoms and assessed statin use based on a review of all medications .
npj Parkinsons Dis: Irritable Bowel Syndrome, May Increase Parkinson's Risk

 Time of Update: 2022-04-24

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In a cohort analysis based on the Swedish Twin Registry, there was no statistically significant increase in PD risk associated with IBS (HR=1. 1038/s41531-020-00145 -8 Irritable bowel syndrome and Parkinson's disease risk: register-based studies. 1038/s41531-020-00145 -8 Irritable bowel syndrome and Parkinson's disease risk: register-based studies.
Drinking too much coffee will shrink the brain volume?

 Time of Update: 2022-04-24

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daily consumptiondaily consumption daily consumptionMR analysis based on the IVW method showed that coffee consumption was inversely correlated with gray matter volume (β = -0. MR analysis based on the IVW method showed that high coffee consumption was associated with reduced gray matter volume (β = -0.
Stroke: The effect of age on systemic inflammation in patients with ST-segment elevation myocardial infarction and acute ischemic stroke

 Time of Update: 2022-04-24

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Greater area under the curve for IL-6 and sTNF-RI, lower lymphocyte count, and higher neutrophil-lymphocyte ratio at 24 hours in STEMI and AIS patients were associated with older age after multivariate analysis .
npj Parkinsons Dis: Dynamic network impairments underlie cognitive fluctuations in dementia with Lewy bodies

 Time of Update: 2022-04-24

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Figure 2 Brain fMRI changesFigure 2 Brain fMRI changesCompared with healthy age-matched controls, DLB patients exhibited functional features of reduced network integration and low temporal variability, which may be directly related to subjective and objective measures of cognitive fluctuations .
Neurology: Identifying late-onset neuropsychiatric symptoms in elderly patients may benefit clinical outcomes!

 Time of Update: 2022-04-24

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Neuropsychiatric Symptoms (NPS) Mild Behavioral Impairment (MBI)One possibility is that incorporating NPS into the case finding of non-dementia populations may improve the specificity of MCI .
European Radiology: Application of Convolutional Neural Networks in Automatic Detection of Brain Metastases

 Time of Update: 2022-04-24

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Our CNN model accurately detected this lesion (arrow) in black (c) and light (d) images Figure 60-year-old woman with lung cancer and multiple brain metastases .
Neurology: Differential effects of apolipoprotein e and modifiable risk factors on hippocampal volume loss and memory decline in the elderly

 Time of Update: 2022-04-23

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We conducted a prospective study to determine cardiovascular risk factors, aging, dementia incidence (caide) risk score and hippocampal volume (hv) loss and episodic memory (em) decline in cognitively normal (cn) older adults.

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Study of Nervous System

The BMJ: Intervention effects of opioid dose reduction in chronic noncancer pain

npj Parkinsons Dis: Integrating 4 million clinical data in the UK, what are the characteristics of the incidence of Parkinson's?

npj Parkinsons Dis: Parkinson's disease, the inflammasome facilitates the assessment of the condition

Neurology: Long-term ECG monitoring (PCM) after stroke improves the detection rate of atrial fibrillation and starts the application of anticoagulant drugs. The long-term benefits of stroke prevention need to be further demonstrated!

NEUROLOGY: Loneliness linked to increased risk of dementia

Age & Ageing: In 1 in 4 hospitalizations, recurrent delirium can increase dementia risk by 7.8 times!

npj Parkinsons Dis: What inspires us about Parkinsons morbidity, prevalence and mortality across Norway?

JCI: Children with complete IRF8 deficiency are susceptible to alveolar proteinosis and multiple infectious diseases

BMJ: Attention!

Brain Shenzhen Children's Hospital: Genome sequencing is expected to become the preferred method for genetic testing of epilepsy children in my country

Neurology: Relationship between modified rankin scale and recovery phenotype in patients with upper extremity weakness after stroke

NEJM: Endovascular therapy combined with thrombolysis in patients with massive acute stroke

Neurology: Statins may be mediated by lower risk of cerebral atherosclerosis and may reduce Parkinson's risk in adults!

npj Parkinsons Dis: Irritable Bowel Syndrome, May Increase Parkinson's Risk

Drinking too much coffee will shrink the brain volume?

Stroke: The effect of age on systemic inflammation in patients with ST-segment elevation myocardial infarction and acute ischemic stroke

npj Parkinsons Dis: Dynamic network impairments underlie cognitive fluctuations in dementia with Lewy bodies

Neurology: Identifying late-onset neuropsychiatric symptoms in elderly patients may benefit clinical outcomes!

European Radiology: Application of Convolutional Neural Networks in Automatic Detection of Brain Metastases

Neurology: Differential effects of apolipoprotein e and modifiable risk factors on hippocampal volume loss and memory decline in the elderly