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3 truths you need to know about carotid plaque!
Time of Update: 2022-04-23
Carotid artery plaque screening is necessary, but it must be reasonably standardized!Asymptomatic carotid stenosis (aCAS) is an important risk factor for stroke .
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Nearly 80,000 people followed up for 18 years: To prevent stroke, should you drink milk or yogurt?
Time of Update: 2022-04-23
This study investigated the association of updated information on milk and fermented milk consumption timing (1997 and 2009) with total stroke, cerebral infarction and hemorrhagic stroke risk in 79,618 Swedish women and men (mean age 61.
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Alzheimers Dementia: What are the clinical characteristics of dementia patients in a survey of 4 million people?
Time of Update: 2022-04-23
12635Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.
12635Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.
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Alzheimers Dementia: Inherited dementia with decreased nuclear integrity of the locus coeruleus followed by increased tau aggregation
Time of Update: 2022-04-23
In older adults, including preclinical sporadic AD, with specialized magnetic resonance imaging (MRI) methods, LC integrity peaks and begins to decline at age 54, which is the time in life when cortical tau begins to appear .
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NEJM: Hydrocortisone treatment started 2 weeks after birth does not significantly improve survival without moderate to severe bronchopulmonary dysplasia in premature infants
Time of Update: 2022-04-23
In preterm infants with bronchopulmonary dysplasia, treatment with hydrocortisone starting from postnatal days 14 to 28 did not improve survival without moderate to severe bronchopulmonary dysplasia, nor did the 2-year neurodevelopmental outcomes differ significantly between groups .
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Alzheimers Dementia: Integrating 8 countries, 10,000 big data: more exercise can reduce dementia risk
Time of Update: 2022-04-23
Several previous studies have examined the potential dose-response relationship between later-life physical activity and dementia risk .
of Fudan University conducted a pooled analysis based on 10 cohorts of COSMIC to investigate the dose-response relationship between physical activity in later life and the risk of developing dementia .
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JAMA: Left atrial function associated with dementia risk
Time of Update: 2022-04-23
80 cases of dementia were diagnosed in the lowest 1/5 of left atrial storage strain (LASr), 3.
20 cases of dementia were diagnosed in the lowest 1/5 of left atrial emptying fraction (LAEF), 3.
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Neurology: Brain functional imaging confirms altered dentate and globus pallidus functional connectivity in patients with focal dystonia, supporting that focal dystonia is a network-specific disease!
Time of Update: 2022-04-23
Resting-state functional MRI (rs-fMRI) studies aimed at identifying functional connectivity (FC) patterns , including whole-brain and seed-based approaches, have detected a wide range of functional changes in and out of sensorimotor circuits in patients with CD and BSP, with abnormalities in multiple brain regions Communication between, especially the basal ganglia and cerebral cortex .
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Neurology: Cognitive Outcomes 1 Year After Mild Traumatic Brain Injury: Results from the TRACK-TBI Study
Time of Update: 2022-04-23
The study objectives were to develop and establish the concurrent validity of a clinically relevant definition of cognitive impairment 1 year after mild traumatic brain injury (MTBI), to compare baseline characteristics of different cognitive outcome groups, and to determine whether routine baseline clinical variables could be used to predict 1-year adverse cognitive outcomes .
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Alzheimers Dementia: Specific indicators in the blood are closely related to pathological changes in the brain
Time of Update: 2022-04-23
Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort .
12639)Examining the association between blood‐based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort
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JAMA Neurology: Association of Tourette Syndrome and Chronic Tic Disorder with Violent Assault and Criminalization
Time of Update: 2022-04-23
JAMACox proportional hazards regression models were used to estimate the risk of violent assault and criminal conviction in patients with TS or CTD compared with the general population and unaffected siblings .
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Parkinson's drug CVN424, good news from clinical trials!
Time of Update: 2022-04-23
The results showed that, in addition to meeting safety endpoints, CVN424 was able to significantly reduce the time to relapse of Parkinson's symptoms, known as "off time .
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HUAN BRAIN MAPPING: Structural connectivity-functional connectivity coupling predicts sound therapy outcomes in patients with idiopathic tinnitus
Time of Update: 2022-04-23
original sourceoriginal sourceDistinct brain structural-functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy.
25848Distinct brain structural-functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy.
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npj Parkinsons Dis: Zhejiang University - The age of onset of Parkinson's disease is different, and the immune status is different
Time of Update: 2022-04-23
An abnormal immune system increases susceptibility to PD;In particular, previous studies have linked PD to autoimmune disease, microglial activation, histopathology of peripheral immune cell infiltration in the brain, and immune cell and cytokine dysregulation in peripheral blood .
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Brain: These factors are associated with early-stage multiple sclerosis progression and relapse!
Time of Update: 2022-04-23
The aim of this study was to investigate the contribution of relapse-related worsening and progression independent of relapsing activity to the accumulation of confirmed disability in patients with clinically isolated syndrome and early-stage relapsing-remitting MS, assessed within one year of onset, with follow-up >/=5 Years (n = 5169) .
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JNER: A randomized clinical controlled study on the efficacy of three-dimensional upper limb robotic exoskeleton training on chronic stroke
Time of Update: 2022-04-23
To achieve this goal, in this study, we compared the efficacy of robotic training using a multi-joint functional exoskeleton in goal-directed training with conventional physical therapy regimens in terms of clinical and functional outcomes, both in terms of intensity and time the same .
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JAMA Network Open: 3% hypertonic salt is more effective than mannitol in treating high intracranial pressure in children with severe traumatic brain injury
Time of Update: 2022-04-23
published a research article in JAMA Network Open entitled Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury, describing the current characteristics of hypertonic drug use in children with sTBI , and to assess whether HTS or mannitol were associated with greater reductions in intracranial pressure (ICP) and/or increases in cerebral perfusion pressure (CPP) .
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HUAMN BRAIN MAPPING: CBF as an alternative method for measuring rs-FC
Time of Update: 2022-04-23
CBF-based resting-state functional magnetic resonance imaging (rs-fMRI) can replace BOLD-based rs-fMRI to obtain reliable rs-FC when the total acquisition time exceeds 10 min .
CBF-based resting-state functional magnetic resonance imaging (rs-fMRI) can replace BOLD-based rs-fMRI to obtain reliable rs-FC when the total acquisition time exceeds 10 min .
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Nature: People who grew up in the city are prone to road idiots
Time of Update: 2022-04-23
Structured, grid-like layouts outside cities are less regular These findings suggest that the environment in which people grow up (particularly street structure) affects their ability to navigate, and that people navigate better in environments with similar structures to where they grew up .
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npj Parkinsons Dis: fMRI, useful for discovering which Parkinsons patients are suitable for deep brain stimulation
Time of Update: 2022-04-23
Figure 2 Schematic diagram of fMRI resultsFigure 2 Schematic diagram of fMRI resultsAt baseline, network analysis showed higher mean nodal intensity, local efficiency, and clustering coefficient in the occipital region of DBS-eligible individuals over time relative to controls and patients who were not eligible for DBS .
