NEUROLOGY: Loneliness linked to increased risk of dementia

Loneliness is a risk factor for increased morbidity and mortality, and prevalence is rising, from 11% to 14% in a US population-based sample over a 2-year period from the early days of the COVID-19 pandemic
.

It is estimated that the prevalence of loneliness in adults aged 60 is higher in the US and international populations (13% 43%)

Loneliness is a risk factor for increased morbidity and mortality, and prevalence is rising, from 11% to 14% in a US population-based sample over a 2-year period from the early days of the COVID-19 pandemic

Joel Salinas et al.

The study participants assessed loneliness and were free of dementia at baseline
.

Loneliness (feeling lonely ≥3 days in the past week) was recorded using the Center for Epidemiological Research Depression Scale

The study participants assessed loneliness and were free of dementia at baseline

Of the 2308 participants (mean age 73 [SD 9] years, 56% female) eligible for the dementia sample, 14% (329 of 2308) had dementia, 6% (of 2308) 144) felt lonely

Lonely (relative to not lonely) adults had a higher 10-year dementia risk (age-, sex-, and education-adjusted hazard ratio 1.

 Lonely participants younger than 80 years without the APOE 4 allele had a 3-fold increased risk of APOE (adjusted hazard ratio 3.

10-year all-cause dementia incidence curve for the primary outcome in the subgroup of participants aged 60 to 79 years with the APOE ε4 allele (-)
.

10-year all-cause dementia incidence curve for the primary outcome in the subgroup of participants aged 60 to 79 years with the APOE ε4 allele (-)
.

 In a cognitive sample of 1875 eligible non-dementia patients (mean age 62 [SD 9] years, 54% female), loneliness was associated with poorer executive function, lower total brain volume, and greater white matter damage
.

 In a cognitive sample of 1875 eligible non-dementia patients (mean age 62 [SD 9] years, 54% female), loneliness was associated with poorer executive function, lower total brain volume, and greater white matter damage
.

This study of close clinical dementia monitoring over 10 years found that loneliness was associated with an increased risk of dementia ; this tripled in adults representing the majority of the U.
S.
population whose baseline risk was based on age and genetic risk relatively low
.

Loneliness was also associated with poorer neurocognitive markers of ADRD susceptibility, suggesting an early pathogenic role

This study of close clinical dementia monitoring over 10 years found that loneliness was associated with an increased risk of dementia ; this tripled in adults representing the majority of the U.

original source

Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline.

Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline.
Joel Salinas, Alexa S.
Beiser, Jasmeet K.
Samra, Adrienne O'Donnell, Charles S.
DeCarli, Mitzi M.
Gonzales, Hugo J.
Aparicio , Sudha Seshadri.
Neurology Mar 2022, 98 (13) e1337-e1348; DOI: 10.
1212/WNL.
0000000000200039.
  https://doi.
org/10.
1212/WNL.
0000000000200039 https://doi.
org/10.
1212/WNL.
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