-
Neurology: Health-related quality of life trajectories in people with multiple sclerosis
Time of Update: 2022-09-30
The study identified a group of patients with multiple sclerosis who reported similar physiological and psychological HRQoL trajectories over time.
The study identified a group of patients with multiple sclerosis who reported similar physiological and psychological HRQoL trajectories over time.
-
Eisai/Bojian Aβ antibody lecanemab successfully in the treatment of Alzheimer's disease stage III and successfully slowed cognitive decline (Clarity AD study)
Time of Update: 2022-09-30
On September 28, 2022, Eisai / Biogen jointly announced that the Phase III Clarity AD clinical study of lecanemab anti-amyloid β (Aβ) antibody lecanemab for the treatment of mild cognitive impairment (MCI) induced by Alzheimer's disease (AD) has achieved positive key results, that is, the primary endpoint and all key secondary endpoints have been met and the results are statistically significant.
-
Advances in thrombolytic therapy in patients with mild stroke
Time of Update: 2022-09-30
A retrospective analysis of the 2005 National Institute of Neurological Disorders and Stroke (NINDS) rt-PA stroke study demonstrated that the thrombolytic group benefited from intravenous thrombolysis compared with the placebo group, and the proportion of good outcomes was significantly higher than that in the placebo group, while the incidence of sICH in the thrombolytic group was 0.
-
Neurology: behavioral and cognitive phenotype of patients with amyotrophic crest lateral sclerosis carrying the superoxide dismutase 1 gene variant
Time of Update: 2022-09-30
0000000000201044 SOD1 variants in patients with amyotrophic lateral sclerosis (ALS) are associated with specific clinical features and disease progression, but rarely with cognitive and behavioral impairment.
0000000000201044 SOD1 variants in patients with amyotrophic lateral sclerosis (ALS) are associated with specific clinical features and disease progression, but rarely with cognitive and behavioral impairment.
-
Neurology: How epilepsy, vascular risk factors, and cognitive function relate
Time of Update: 2022-09-30
In the Cardiovascular Health Study (CHS), as an example of this excessive decline due to the interaction of epilepsy and another factor, the average global cognitive decline in older adults with epidemic epilepsy and apolipoprotein 4 alleles has greatly exceeded expectations.
-
Cell: GM pigs offer new perspectives on the treatment of Alzheimer's!
Time of Update: 2022-09-30
02 Can I test drugs before the disease breaks out?Olav Michael Andersen said: "We know from human genetics that when the SORL1 gene is destroyed, we develop Alzheimer's.
-
Current view: spinal cord electrical stimulation for neurogenic pain
Time of Update: 2022-09-30
In addition, some patients have attenuated pain relief after permanent implantation of the stimulator.
In addition, some patients have attenuated pain relief after permanent implantation of the stimulator.
In addition, some patients have attenuated pain relief after permanent implantation of the stimulator.
-
Antiplatelet therapy for noncardiac stroke stroke
Time of Update: 2022-09-30
4. Ischemic stroke or TIA patients with symptomatic intracranial artery stenosis (70% to 99% stenosis) within 30 days of onset should be given aspirin plus clopidogrel for 90 days as early as possible (grade II recommended, grade B evidence).
-
Nat Neurosci: Science has found that electrical stimulation through the scalp can improve a person's memory
Time of Update: 2022-09-30
Based on the study, the team showed that stimulating the dorsolateral prefrontal cortex (a region near the front of the brain) with high-frequency currents improves long-term memory, while stimulating the sub-parietal lobe located deeper in the brain, enhancing working memory with low-frequency currents.
-
Neurology: Herpes virus affects white matter and cognitive function in the elderly
Time of Update: 2022-09-30
, of the Behavioral Neuroscience Laboratory at the National Institute of Aging in Baltimore, USA, published research papers in Neurology, hypothesizing that sHHV is associated with cognitive decline (especially memory), as well as biomarker-defined amyloidosis, reactive astrocyte hyperplasia, and higher levels of neurodegeneration.
-
Secondary prevention of ischemic stroke
Time of Update: 2022-09-30
Stroke, commonly known as stroke, can be divided into ischemic stroke and hemorrhagic stroke, and stroke is the second leading cause of death worldwide and the number one cause of acquired long-term d
-
ECG manifestations of acute stroke, do you have a mastery?
Time of Update: 2022-09-30
4 Effects of acute stroke site on electrocardiogramDepending on the site of acute stroke, ECG findings vary:(1) More patients with temporal, frontal and parietal stroke have ECG changes;(2) Ischemic T wave inversion often occurs in patients with left parietal lobe and right frontal lobe cerebral infarction;(3) The incidence of arrhythmias in cerebral hemisphere stroke is higher than that in patients with brainstem stroke;(4) Acute stroke of the insula of the brain may cause sinus tachycardia, pre-stage contraction, and ST-segment elevation.
-
Mol Psychiatry: Too much pressure, teenagers don't want to socialize? Scientists have revealed that leptin may alleviate the lack of social pleasure induced by adolescent stress
Time of Update: 2022-09-30
Lack of pleasure is the core symptom of depression, which can be divided into physical pleasure loss and social pleasure loss, the former manifested as the loss of pleasant sensations of individual ph
-
Neurology: Relationship between gender, age, and cardiometabolic risk profiles and brain structure and cognition: a potential category analysis of a UK biobank
Time of Update: 2022-09-30
Recently, a study published in Neurology explored the relationship between the underlying categories of middle-aged individuals clustered by age, sex, menopause, and cardiac metabolic health and brain structure and cognitive performance.
-
A Blockbuster Review: A Comprehensive Summary of the Neurological Effects of COVID-19
Time of Update: 2022-09-30
Introduction: As we all know, COVID-19 mainly affects the respiratory tract of patients, causing serious damage to the respiratory system of patients. But recently, Harvard University neurology author
-
Neurology: relationship between blood inflammation biomarkers and penumbral region depletion in patients with acute ischemic stroke after mechanical thrombosis
Time of Update: 2022-09-30
Recently, a study published in Neurology evaluated the relationship between blood biomarkers of inflammation and penumbral lesion growth in patients with acute ischemic stroke (AIS) after receiving mechanical thrombotomy (MT).
-
Reperfusion therapy for acute ischemic stroke
Time of Update: 2022-09-30
5 hours of onset – intravenous thrombolytic therapyThere have been multiple clinical trials evaluating the efficacy and safety of rt-PA venous thrombolysis in acute cerebral infarction, and the treatment time window of the study includes 3h, 3-4.
-
Int J Neuropsychopharmacol: Structural and functional abnormalities in the olfactory-related regions of the AD spectrum worsen with disease severity
Time of Update: 2022-09-30
Odor recognition (OI) dysfunction is an early marker of Alzheimer's disease (AD), but it is unclear how the olfactory-related region transitions from the stages of subjective cognitive decline (SCD) and mild cognitive impairment (MCI) to AD dementia.
-
Movement disorders: Dietary quality is related to the precursor characteristics of Parkinson's disease in Chinese adults
Time of Update: 2022-09-30
In terms of individual PD prodromal characteristics, according to mAHEI assessment, better dietary quality was associated with a lower chance of excessive daytime sleepiness and constipation (P-trend <0.
-
Neurology: Diagnostic value of ECG-gated cardiac CT and transthoracic echocardiography in the acute phase of ischemic stroke
Time of Update: 2022-09-30
Recently, a study published in Neurology determined whether cardiac CT obtained during initial stroke imaging had a higher detection rate than transthoracic echocardiography (TTE) in detecting high-risk cardio-aortic embolization sources.
