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Assessment of coronary heart disease and ischemic stroke, the latest guidelines are coming!
Time of Update: 2022-10-01
Recurrent unstable angina or myocardial infarction may be considered in patients in the stable phase after medication, PCI, and coronary artery bypass grafting:(1) Frequent angina in the past 1 month;(2) (spontaneous) angina at rest;Assessment of ischemic strokeRecurrent strokes should be considered in patients with a history of previous stroke who suddenly develop one or more of the following conditions.
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How much do you know about the diagnosis and treatment of chronic fatigue syndrome?
Time of Update: 2022-10-01
m. and at bedtime), morning cortisol, antinuclear antibodies, thyroid-stimulating hormone, free thyroxine, C-reactive protein, vitamin B12, erythrocyte sedimentation rate, 25-dihydroxyvitamin D, ferritin, 。 Question FourWhat non-pharmacological treatment is recommended for ME/CFS-related post-exercise discomfort?A.
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The course of treatment for drug overuse headaches is recommended on the Knowledge Card
Time of Update: 2022-10-01
Medical pulse passGuideIn 2019, Xiaobian launched the "Knowledge Card" column, which organizes some clinical disease-related knowledge points in the form of simple and easy-to-save tables, so that clinicians can use fragmented time to learn from the past, which is quite popular with doctor readers!
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Skin cells successfully transform into neurons! What does this mean for patients with Parkinson's disease who have lost neurons?
Time of Update: 2022-10-01
The study data reflect that functional neurons generated from adult skin fibroblasts are age-specific, enabling age-related aspects of Parkinson's disease to be modeled.
The study data reflect that functional neurons generated from adult skin fibroblasts are age-specific, enabling age-related aspects of Parkinson's disease to be modeled.
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Today's Science reveals for the first time: a mysterious network of blood vessels that protects the whale's brain from damage
Time of Update: 2022-10-01
Now, a new study published in the journal Science has unveiled this mysterious mechanism: a network of blood vessels, the retia mirabilia (also known as the "strange web"), protects the brain and allows cetaceans to swim smoothly in the ocean.
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The new theory is that Alzheimer's disease is not a brain disease in nature, but an autoimmune disease
Time of Update: 2022-10-01
The research team believes that while traditional drugs that treat autoimmune diseases may not be effective against Alzheimer's disease, other immunomodulatory pathways that target the brain may find new and effective treatments from them.
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Express reduces opioid consumption by nearly 80%, and the clinical results of long-acting local analgesics phase 3 are positive
Time of Update: 2022-10-01
▲If you have any business needs, please long press to scan the QR code above, or▎Editor of WuXi AppTec content teamRecently, Pacira BioSciences published positive data from a Phase 3 clinical trial of its drug EXPAREL as a single-dose popliteal sciatic blocker for postoperative local analgesia in patients undergoing bunion resection.
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Memory saved? Stimulates the brain or helps improve memory
Time of Update: 2022-10-01
According to a study published August 22 in Nature Neuroscience,[1] Robert Reinhart, a cognitive neuroscientist at Boston University, and colleagues showed that repeated stimulation of the brains of adults over the age of 65 with a weak electric current for several days led to memory improvements that lasted up to a month.
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Unresponsive don't just think of dementia
Time of Update: 2022-10-01
Qualitative diagnosis:• CPM: the patient has a history of severe hyposodium, normal sodium supplementation within 1 day, blood sodium rise of 26mmol/L, sudden apathy, slow response, accompanied by involuntary dancing of both upper limbs, the disease may be considered, although the fourth day of the onset of the skull MRI did not show the performance of pontine demyelination, but there are literature reports that the imaging changes of CPM can lag behind the clinical manifestations by 2 weeks.
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Is it mating or fighting? The Nature paper reveals the decision-making mechanism of "love and hate" in the mouse brain
Time of Update: 2022-10-01
Previous studies have shown that the terminal bed nucleus (BNST) is a key relay station for olfaction-behavior, receiving olfactory-recognized sex information from the amygdala and subsequently projecting it onto different hypothalamic nuclei to control mating (controlled by the medial anterioptic MPOA) and aggressive behavior (controlled by the ventral medial hypothalamic ventral lateral nucleus VMHvl), respectively.
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Nat Commun Xu Tianle/Li Weiguang/Zhang Siyu teamwork reveals the neural circuit organization law of "one-click switching" of good and bad emotions
Time of Update: 2022-10-01
On September 21, 2022, the team of Professor Xu Tianle and Zhang Siyu of the School of Basic Medical Sciences of Shanghai Jiao Tong University, the National Children's Medical Center (Shanghai) Children's Brain Science Center, and Li Weiguang, a researcher at the Institute of Brain Science Transformation of Fudan University, published Insular cortical circuits as an executive gateway to decipher online in Nature Communications A research paper on threat or extinction memory via distinct subcortical pathways.
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Spotlight: Effect of the FcRn antagonist efgartigimod on protective antibodies and vaccination efficacy in vivo patients with pemphigus and myasthenia gravis
Time of Update: 2022-10-01
In individual patients with gMG receiving ADAPT+ therapy, the first dose and the second dose (day 1) BNT162b2 (A-C) before and after treatment with IgG levelsInfluenza vaccine: Patients with no significant reduction in IgG levels after vaccination, a clear immune response to all tests, and A/H1N1, A/H3N2, and/or B/Y antibody titers can meet or exceed the protection threshold✔ Patients 10 and 11 were vaccinated between two treatment cycles of efgartigimod (Figure 3A).
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Deadly brain tumors are hopefully prevented! On the same day, two articles "Nature" uncovered the root causes of tumors buried in brain development
Time of Update: 2022-10-01
Academic Latitude and Longitude Related Reading:Nature: Nearly 90,000 cells were sequenced individually, and the individualized treatment of children's brain tumors completed the groundbreaking workThey found that these mutations cause genes to lose function, with the result that normal differentiation of cells is blocked in specific cell types.
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Neuron Huazhong University of Science and Technology Lu Youming/Zhu Lingqiang collaborated to reveal the mechanism of action of cholinergic neurons that regulate anxiety and memory
Time of Update: 2022-10-01
iNatureThe cholinergic system powerfully regulates the physiology and behavior of health and disease, and it is the most widely used pharmacological target for improving the progression of Alzheimer's
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Movement disorders: What is the difference between serotonin transporter imaging in multisystem atrophy and Parkinson's disease?
Time of Update: 2022-09-30
The significance of the study was to find that patients with MSA had more severe serotonin deletions in the brainstem and some subcortical regions of the forebrain compared to patients with Parkinson's disease, and showed a specific association with MSA in the severity of movement disorders.
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Key points of imaging diagnosis - central nervous system and ears, nose, throat
Time of Update: 2022-09-30
Key points of imaging diagnosis - central nervous system and ears, nose, throatClassification of skull fractures:☆ depending on the location: vault fracture, skull base fracture☆ Open by opening: clos
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Neurology: Health-related quality of life trajectories in people with multiple sclerosis
Time of Update: 2022-09-30
The study identified a group of patients with multiple sclerosis who reported similar physiological and psychological HRQoL trajectories over time.
The study identified a group of patients with multiple sclerosis who reported similar physiological and psychological HRQoL trajectories over time.
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Transparent spacer cavity, intermediate sail cavity image diagnosis points
Time of Update: 2022-09-30
Ventricular anatomy, normal variationTransparent spacer cavitytermimageNarrow, finger-like cerebrospinal fluid accumulation between the lateral ventriclesThe size ranges from crack to a few millimeters, and occasionally > 1 cmThe fetal transparent septum is all cysticThe transparent spacer is seen in 15% to 20% of adultsThe main differential diagnosispathologyClinical points(Left) crown and axial inset plots show typical representations of transparent spacer and Verga cavity.
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Eisai/Bojian Aβ antibody lecanemab successfully in the treatment of Alzheimer's disease stage III and successfully slowed cognitive decline (Clarity AD study)
Time of Update: 2022-09-30
On September 28, 2022, Eisai / Biogen jointly announced that the Phase III Clarity AD clinical study of lecanemab anti-amyloid β (Aβ) antibody lecanemab for the treatment of mild cognitive impairment (MCI) induced by Alzheimer's disease (AD) has achieved positive key results, that is, the primary endpoint and all key secondary endpoints have been met and the results are statistically significant.
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"Mini brain" sign in the vertebral body【YXZX087】
Time of Update: 2022-09-30
The "mini-brain" sign on MR axis images has been reported to be characteristic of isolated vertebral plasma cell tumors.
The "mini-brain" sign on MR axis images has been reported to be characteristic of isolated vertebral plasma cell tumors.
