Movement disorders: Dietary quality is related to the precursor characteristics of Parkinson's disease in Chinese adults

Dyskinesia, such as tremor, stiffness, and bradykinesia, are the leading clinical manifestations
of Parkinson's disease (PD).

Therefore, the pre-exercise and prodromal phases may be a key window
for early diagnosis and prevention.

Better diet quality, such as assessed by overall diet quality scores such as the Alternative Healthy Diet Index (AHEI) and the Alternative Mediterranean Diet (MED), was associated
with a lower risk of PD events and PD prodromal symptoms.

Although increasing population size and longevity in Asian countries contributes to increased PD prevalence, there are few records of similarities and differences in genetic and environmental risk factors for PD in Asian and European descent, such as diet, and there are largely no conclusions
.

Thus, Xinyuan Zhang of Pennsylvania State University and others studied the relationship between
overall dietary quality and precursor PD in more than 70,000 Chinese adults.

A total of 71,640 PRD-free Chinese participants
were included in this cross-sectional study.

After adjusting for age, sex, lifestyle factors, total energy intake, and other potential confounding factors, the probability of having a PD prodromal symptom combination (1 and 2+ symptoms versus 0 symptoms) was calculated using Logistic regression
.

In the multivariate adjustment model, the OR with 2+ and 0 precursor PD characteristics was 0.

In terms of individual PD prodromal characteristics, according to mAHEI assessment, better dietary quality was associated with a lower chance of excessive daytime sleepiness and constipation (P-trend <0.

There was a slight significant association between aMED and precursor PD characteristics (adjusted OR values compared to extreme quartile = 0.

Assessed by mAHEI and aMED, better dietary quality was associated
with a lower probability of precursor PD traits in Chinese adults.

Zhang X, Xu J, Liu Y, Chen S, Wu S, Gao X.