-
Cell Rep Med: Reactogenicity of Multiple COVID-19 Vaccination Regimens and Immunogenicity to Omicron Cell Press Paper Express
Time of Update: 2022-08-20
Different experiments have analyzed the reactogenicity, immunogenicity and efficacy of BNT162b2 or mRNA-1273 as a second dose of mRNA vaccine in individuals vaccinated with ChAdOx1-S, and these studies have consistently shown that it is comparable to the homologous regimen ChAdOx1-S.
-
Anti-MDA5 antibody positive dermatomyositis, early typing may reduce mortality!
Time of Update: 2022-08-20
RESULTS: The study further succeeded in classifying patients with anti-MDA5 + dermatomyositis into three clinical subtypes of low, intermediate and high RP-ILD risk groups, finding patients' rash and inflammatory status (ESR, CRP, ALT, AST and LDH) is an important feature to distinguish groups .
-
Nat Commun Wang Yongxiang and Luo Cheng collaborated to discover that the new 33 peptide tag can improve the solubility and stability of single-chain antibodies
Time of Update: 2022-08-20
Recently, the research team of Wang Yongxiang from the Ministry of Education of Medical Molecular Virology/Health and Health Commission/Key Laboratory of the Chinese Academy of Medical Sciences, School of Basic Medicine, Fudan University, and Luo Cheng's research group from the State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, expressed the solubility of single-chain antibodies in Escherichia coli.
-
How are people with rheumatism vaccinated?
Time of Update: 2022-08-20
High-dose and adjuvant influenza vaccines are conditionally recommended for elderly patients with rheumatism ≥65 years of age and those aged >18 years and 18 years of age who are receiving immunosuppressive therapy .
-
Such vasculitis patients, pay attention to the risk of atherosclerosis!
Time of Update: 2022-08-20
Download the Doctor Station App and subscribe anytime, anywhere~*For medical professional reading reference onlyClinical information, reachable in 1s ▎Clinical question: Is there an increased risk of subclinical atherosclerosis in patients with eosinophilic granulomatosis with polyangiitis (EGPA)?Literature screenshot▎Study protocol: The common carotid artery (CCA) intima-media thickness (IMT) was measured in 40 EGPA patients and 80 controls (matched for age, sex, and traditional cardiovascular risk factors).
-
Interpretation of the top journal on immunization: Cancer and gender
Time of Update: 2022-08-20
Gender differences in cancer incidence and disease development have been widely recognized, but the underlying immunological mechanisms are still unclear. Today, Xiaobian brings you a study published
-
IgG4-related disease or tumor?
Time of Update: 2022-08-20
Malignant tumor?Don't worry, there is too much information about this case, let's summarize the characteristics of the case first:Older men, insidious onset, long course of disease, and multi-system involvement;Diarrhea, hypoalbuminemia, negative urine protein;Low white blood cells, elevated eosinophils, anemia, IgG↑, IgG4↑, IgE↑, low complement;Lacrimal glands, salivary glands, sinuses, ILD, dura mater, pancreas, hepatobiliary duct, ascending colon, peritoneum and mesentery, prostate;Multiple serous cavity effusions, multiple vascular lesions;Multiple lymphadenopathy .
-
When RA patients increase their treatment requirements, how should clinical treatment respond?
Time of Update: 2022-08-20
The overall goal of RA treatment is to improve joint swelling and pain symptoms, control disease progression, reduce disability rate, and improve patients' quality of life [1] .
-
Sci Immuno tumor microenvironmental signals reshape the chromatin landscape to limit potential functions of exhausted T cells
Time of Update: 2022-08-20
In addition, the authors found that tumor-mediated end-stage depletion of cells increased bivalent chromatin at promoters and resulted in decreased gene expression .
In addition, the authors found that tumor-mediated end-stage depletion of cells increased bivalent chromatin at promoters and resulted in decreased gene expression .
-
Plant Cell is unexpected!
Time of Update: 2022-08-20
published a research paper online in The Plant Cell entitled N-terminally truncated helper NLR NRG1C antagonizes immunity mediated by its full-length neighbors NRG1A and NRG1B, revealing unexpected antagonism of small fragments of NLR immune receptors Negatively regulates the function of intact NLR immunoreceptors .
-
What is the safety and efficacy of hydroxychloroquine during pregnancy in lupus patients?
Time of Update: 2022-08-19
Forest plot of effects of hydroxychloroquine (HCQ) use on pregnancy outcomes in women with SLE:In conclusion, this large study of prospectively collected lupus pregnancies showed that women who continued to use HCQ throughout pregnancy had reduced lupus activity with no impairment of pregnancy outcomes .
-
When the heat wave hits, what should patients with Sjögren's syndrome pay attention to in the summer diet?
Time of Update: 2022-08-19
Watermelon contains a lot of water, which can promote body fluid and quench thirst, clear heat and relieve summer heat, especially in summer, suitable for people with Sjogren's syndrome .
-
Rheumatology: Rheumatoid arthritis is associated with increased gut permeability and bacterial translocation, which can be reversed by inflammatory control
Time of Update: 2022-08-19
1093/rheumatology/keac454 Objective: To evaluate the effects of rheumatoid arthritis (RA) and disease-modifying antirheumatic drugs (DMARDs) on intestinal permeability .
1093/rheumatology/keac454 Objective: To evaluate the effects of rheumatoid arthritis (RA) and disease-modifying antirheumatic drugs (DMARDs) on intestinal permeability .
-
Hydroxychloroquine: In the treatment of systemic lupus erythematosus, how can old drugs play new tricks?
Time of Update: 2022-08-19
A retrospective study showed that initiation of HCQ therapy in ILE patients delayed the onset of SLE, a finding that has raised concerns that the drug may alter early disease stages and have long-term effects that reduce subsequent disease severity interest .
-
If someone in the family has rheumatoid, will it be passed on to the children?
Time of Update: 2022-08-19
Research progress on genetic susceptibility to rheumatoid arthritis [J].
Research progress on genetic susceptibility to rheumatoid arthritis [J].
Research progress on genetic susceptibility to rheumatoid arthritis [J].
Research progress on genetic susceptibility to rheumatoid arthritis [J].
-
If you don't drink or eat seafood, why does gout come to you?
Time of Update: 2022-08-19
Gout is a clinical syndrome of tissue damage caused by the disorder of purine metabolism leading to elevated blood uric acid and monosodium urate deposition .
Gout is a clinical syndrome of tissue damage caused by the disorder of purine metabolism leading to elevated blood uric acid and monosodium urate deposition .
-
Immunity: Yale University study confirms that calorie-restricted diet reduces aging-related proteins and may help extend healthy lifespan
Time of Update: 2022-08-19
But are these benefits the same in humans?On August 12, 2022, Yale University researchers published a research paper titled: The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging in the Cell sub-journal Immunity .
-
Rheumatology: Effects of population-based cognitive behavioral therapy on insomnia in patients with rheumatoid arthritis, a randomized controlled trial
Time of Update: 2022-08-19
1093/rheumatology/keac448 OBJECTIVE: The primary objective was to compare the effects of cognitive-behavioral therapy for insomnia (CBT-I) with usual care on sleep efficiency, as measured by polysomnography (PSG) immediately after the intervention at week 7 .
-
ARD: Auxilin is a novel congenital heart block susceptibility gene that directly affects fetal heart function
Time of Update: 2022-08-19
Results: We identified DNAJC6 as a novel fetal susceptibility gene, and reduced cardiac expression of DNAJC6 was associated with disease risk genotypes .
Results: We identified DNAJC6 as a novel fetal susceptibility gene, and reduced cardiac expression of DNAJC6 was associated with disease risk genotypes .
-
J Ethnopharmacol: Yuxuebi tablet inhibits angiogenesis in experimental rheumatoid arthritis by inhibiting LOX/Ras/Raf-1 signaling
Time of Update: 2022-08-19
OBJECTIVE: To evaluate the anti-angiogenic activity of YXB and explore its mechanism of action in collagen-induced arthritis (CIA) rats and VEGF-induced HUVEC .
OBJECTIVE: To evaluate the anti-angiogenic activity of YXB and explore its mechanism of action in collagen-induced arthritis (CIA) rats and VEGF-induced HUVEC .
