If someone in the family has rheumatoid, will it be passed on to the children?

The Kobayashi and his wife have recently been thinking about getting pregnan.

In order to ensure the health of the baby, they consulted the doctor and wanted to do some preparations before pregnancy, but when the doctor asked whether there were genetic or chronic diseases in the family, they were a little hesitan.

Genetic diseases refer to diseases caused by changes in genetic material or controlled by disease-causing gene.

It is worth emphasizing that the pathogenesis of rheumatoid arthritis is not entirely determined by genetic factor.

It is true that some patients show a certain genetic predisposition, such as siblings with rheumatoid disease, or parents and children with rheumatoid diseas.

Molecular genetic studies of rheumatoid arthritis have shown that many susceptibility genes are related to the pathogenesis of rheumatoid arthriti.

Human leukocyte antigen (HLA) class, interleukin (IL) class, signal transducer and activator of transcription 4 (STAT4), peptidyl arginine deiminase 4 (PADI4), tumor necrosis factor (TNF) class, Polymorphisms of susceptibility genes such as protein tyrosine phosphatase non-receptor type 22 (PTPN22), Toll-like receptors (TLRs), and interleukin receptor-associated kinase 1 (IRAK-1) increase the risk of rheumatoid arthriti.

People with a family history of rheumatoid disease have a 3- to 9-fold increased risk; serum rheumatoid factor-positive rheumatoid patients have a 50% chance of passing it on to the next generation, and their first-degree relatives have a 3-fold increased ris.

However, the current research on how much genetic factors can play are divided and not unifie.

Susceptibility genes increase the susceptibility of immune diseases, but they do not represent inevitabilit.

In a study of identical twins in Finnish and British populations, the comorbidity rate of rheumatoid arthritis was found to be between 12-15%, indicating that although identical twins share the same genetic inheritance, in most cases only one of them suffers from i.

Although genetic factors play an important role in the development of rheumatoid arthritis, there are many factors that influence the odds of developing the diseas.

One thing is for sure, if a family member has rheumatoid arthritis, it does not mean that the offspring will suffer from i.

references:

[1] Research progress of genetics of rheumatoid arthritis [J.

[2] Wu Jirong, Chen Yanfe.

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