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What is the safety and efficacy of hydroxychloroquine during pregnancy in lupus patients?

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Hydroxychloroquine (HCQ) has been shown to reduce the risk of SLE (lupus) episodes, lupus nephritis (LN), kidney damage and death from L.

It was hypothesized that previous studies were insufficient to determine the improvement in pregnancy outcomes associated with HC.

Search flowchart for identifying eligible groups:

Methods: Eligible studies included prospectively collected pregnancies in women with lupu.

Queue Features:

Results: Seven cohorts provided 938 pregnancies in 804 wome.

Forest plot of effects of hydroxychloroquine (HCQ) use on pregnancy outcomes in women with SLE:

In conclusion, this large study of prospectively collected lupus pregnancies showed that women who continued to use HCQ throughout pregnancy had reduced lupus activity with no impairment of pregnancy outcome.

References: Clowse MEB, Eudy AM, Balevic S, Sanders-Schmidler G, Kosinski A, Fischer-Betz R, Gladman DD, Molad Y, Nalli C, Mokbel A, Tincani A, Urowitz M, Bay C, van Noord M, Petri .

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