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Rheumatology: Rheumatoid arthritis is associated with increased gut permeability and bacterial translocation, which can be reversed by inflammatory control

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Objective: To evaluate the effects of rheumatoid arthritis (RA) and disease-modifying antirheumatic drugs (DMARDs) on intestinal permeabilit.

Methods: To investigate the integrity of the colonic mucosa, the claudin proteins ZO-1, occludin and claudin-2 were quantified by immunohistochemical staining in colon biopsies from 20 RA patients and 20 age- and sex-matched control.

To explore intestinal permeability, in another cohort of 59 RA patients—21 DMARDs-naïve patients (17 before and after introduction of conventional synthetic (cs) DMARDs), 38 severe RA patients (before and after introduction of biologics) (b) before and after DMARD), and 33 healthy controls, serum concentrations of LPS-binding protein (LBP), sCD14, and zonulin-related protein (ZRP) were assessed by ELIS.

Results: The expression of ZO-1 protein in colon of RA patients was lower than that of controls (mean score ± SE: 6 ± 56 vs 0 ± 43, p=01), while no significant difference was detected in occludin and claudin-2.

Serum LBP and sCD14 concentrations were higher in RA patients than in control.

Unlike bDMARD non-responders and patients treated with csDMARDs, bDMARD responders had significantly lower LBP and sCD14 concentration.

Conclusions: Colonic tight junction proteins are altered in RA patients and serum biomarkers of intestinal permeability are increase.

Source:

Audo R, Sanchez P, Rivière B, et a.

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