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Gender differences in cancer incidence and disease development have been widely recognized, but the underlying immunological mechanisms are still unclear.
Stem cell-like CD8+ T cells refer to CD8+ T cells with self-renewal and proliferation ability, which express the transcription factor TCF-1 and are the key to maintaining durable anti-tumor immunity in immunotherapy
1.
Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
Figure 6.
Figure 7.
CD8+ T cells mediate sex differences in tumor growth, while AR signaling regulates the transition from stem-like CD8+ T cells in males to ultimately exhausted CD8+ T cells
.
This study provides considerable support for AR as a potentially effective therapeutic target in cancer immunotherapy
.
I believe that many male students felt cold when reading this research haha.
However, apart from the concern of "men and women are different", we can learn more highlights, which is different from the ordinary routine of "dry digging and then wet verification".
, The author starts from the wet experiment, interlocks each other, lays a solid foundation, and finally validates the data through mining data, connecting the previous and the next, and finally sublimates from the mouse model data to the human data of tumor patients, which is also the reason why the author can publish the top journal of immunization
.
Learn more dry goods to give birth to trust people, send high scores and good articles, I believe you can too!
Welcome everyone to add students and people to write for the star recommendation▎The moon is a bit round typesetting▎CY.
Literature▎Yang, C.
, Jin, J.
, Yang, Y.
, Sun, H.
, Wu, L.
, Shen, M.
, Hong, X.
, Li, W.
, Lu, L.
, Cao, D.
, et al.
(2022).
Androgen receptor-mediated CD8(+) T cell stemness programs drive sex differences in antitumor immunity.
Immunity 55, 1268-1283 e1269.
For more information on Shengxin analysis questions: 18501230653 (same number on WeChat)
- Stem-like CD8+ T cells dominate sex differences in antitumor immunity
- Androgen receptor (AR) signaling disrupts maintenance of stem-like state in male CD8+ T cells
- Ablation of AR signaling synergizes with T cell-based cancer immunotherapy
- AR expression positively correlates with CD8+ T cell exhaustion in human cancers
Stem cell-like CD8+ T cells refer to CD8+ T cells with self-renewal and proliferation ability, which express the transcription factor TCF-1 and are the key to maintaining durable anti-tumor immunity in immunotherapy
1.
Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
Figure 6.
Figure 7.
CD8+ T cells mediate sex differences in tumor growth, while AR signaling regulates the transition from stem-like CD8+ T cells in males to ultimately exhausted CD8+ T cells
.
This study provides considerable support for AR as a potentially effective therapeutic target in cancer immunotherapy
.
I believe that many male students felt cold when reading this research haha.
However, apart from the concern of "men and women are different", we can learn more highlights, which is different from the ordinary routine of "dry digging and then wet verification".
, The author starts from the wet experiment, interlocks each other, lays a solid foundation, and finally validates the data through mining data, connecting the previous and the next, and finally sublimates from the mouse model data to the human data of tumor patients, which is also the reason why the author can publish the top journal of immunization
.
Learn more dry goods to give birth to trust people, send high scores and good articles, I believe you can too!
END
Don't want to miss the hotspots and technologies every day.Welcome everyone to add students and people to write for the star recommendation▎The moon is a bit round typesetting▎CY.
Literature▎Yang, C.
, Jin, J.
, Yang, Y.
, Sun, H.
, Wu, L.
, Shen, M.
, Hong, X.
, Li, W.
, Lu, L.
, Cao, D.
, et al.
(2022).
Androgen receptor-mediated CD8(+) T cell stemness programs drive sex differences in antitumor immunity.
Immunity 55, 1268-1283 e1269.
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For more information on Shengxin analysis questions: 18501230653 (same number on WeChat)
