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2022 ACR Conference Blockbuster: CD8 T cell-Mediated Psoriatic Arthritis Subtype Newly Discovered in Mouse Models!
Time of Update: 2022-11-25
To fill this gap, we injected serum and peripheral blood mononuclear cells (PBMC) from patients with specific phenotypes (psoriasis simplex, psoriasis with non-erosive arthritis, psoriasis with erosive arthritis, dactylitis) into immunodeficient NSG-SGM3 mice to experimentally evaluate cells and serum factors that promote regional inflammation in PsA.
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2022 ACR Blockbuster: Denosumab Can Significantly Delay the Progression of Erosive Hand Osteoarthritis!
Time of Update: 2022-11-25
Compared with placebo, Denosumab has obvious structural modification effect on erosive hand osteoarthritis, and erosion progression is significantly reduced after 24 weeks of treatment, and the treatment effect is enhanced after 48 weeks.
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ACR 2022 Blockbuster: Bimekizumab Treats Patients with Active Psoriatic Arthritis with Amazing Results!
Time of Update: 2022-11-25
In the Phase 3 BE OPTIMAL study of patients with the biologics DMARD (bDMARD)-naïve, BKZ was superior to placebo (PBO) in the treatment of joint and skin diseases, and data on drug efficacy and safety for up to 52 weeks are presented here.
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Nature | functional antibody light chain consistency
Time of Update: 2022-11-15
Written by | NovemberThe adaptive immune system of vertebrates modifies the genome of individual B cells, encoding antibodies that bind to specific antigens [1], and is the Monkey King in the human body, with seventy-two changes.
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Made 8 differential diagnoses, and finally relied on this trick to clarify the diagnosis!
Time of Update: 2022-11-15
*For medical professionals onlyDuring the diagnosis process, be sure to keep a clear head~ Synopsis: The young man of the patient thought it was just ankylosing spondylitis (AS), but he did not expect
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"Nature": Internet celebrity dietary fiber inulin adds new worries! Cornell's team found that inulin induces an allergy-like immune response
Time of Update: 2022-11-15
Guo Chunjun and his colleagues at Weill Cornell Medical College in the United States found that inulin leads to an increase in the level of bile acids in the serum by changing the structure of the intestinal flora and its metabolite composition, which can cause type 2 inflammation and eosinophilia, which can aggravate allergic reactions in mice and enhance the body's defense under helminth infection [3].
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Chi Hongbo and other teams have written 6 Nature/Cell/NCB articles in 1 year, and have made important progress in the field of immunization
Time of Update: 2022-11-15
iNaturePhosphatase and tensin homologue (PTEN) is a frequently mutated tumor suppressor gene that plays an important role in T cell biology. Mice carrying PTEN-deficient T cells form T-cell lymphoma a
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The first prescription for the subcutaneous dosage form of tocilizumab was issued in many places across the country, and Chinese RA patients have a more friendly treatment!
Time of Update: 2022-11-15
*For medical professionals onlyInnovative drugs have been approved for new dosage forms to help the clinical treatment of RA!Tocilizumab opened the era of "double dosage form" and helped the long-term
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From the change of classification standards, we can see the development journey of RA early diagnosis and early treatment
Time of Update: 2022-11-15
The scoring system includes varying numbers of joint involvement, serologic results (rheumatoid factor versus anti-cyclic citrullinated peptide antibodies), acute reactants (C-reactive protein versus erythrocyte sedimentation rate), and duration of symptoms, and the diagnosis of RA is confirmed when the patient achieves an overall score of at least six points [5].
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The truth of numbness in the limbs, is actually Sjogren's syndrome playing tricks?
Time of Update: 2022-11-15
Deputy Chief Physician Yang Yue commented: Although the clinical symptoms of patients are not typical, doctors still focus on the investigation of autoimmune diseases through this layer-by-layer, peeling and cocooning differential analysis, obtain certain clues through the positive of the patient's autoantibodies, further improve the ophthalmic salivary gland function and other examinations, get more evidence, and finally diagnose Sjogren's syndrome through lip gland biopsy.
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Gout is well controlled and the risk of high blood pressure is reduced?
Time of Update: 2022-11-15
Download the Doctor Station App and subscribe anytime, anywhere~*For medical professionals onlyClinical information, 1s reach Clinical question: Observational studies have demonstrated an association between gout and high blood pressure, but are they causal?
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Regarding the medication of osteoarthritis, you need to know at least these three points!
Time of Update: 2022-11-15
2. Joint2022 edition of the "Osteoarthritis Diagnosis and Treatment Specifications" believes that intra-articular injection of sodium hyaluronate can reduce pain, inhibit cartilage matrix decomposition, activate the cartilage tissue self-repair process, etc.
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CMI(IF=22) Zhang Yu, Chinese Academy of Medical Sciences/Liu Zhihua of Tsinghua University, found that a high-fiber diet synergizes with specific gut flora and exacerbates rheumatoid arthritis
Time of Update: 2022-11-15
On November 2, 2022, Zhang Yu of the Chinese Academy of Medical Sciences/Peking Union Medical College and Liu Zhihua of Tsinghua University jointly published a joint communication entitled "A high-fiber diet synergizes with Prevotella copri and exacerbates" online in Cellular & Molecular Immunology (IF=22).
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Immunity angels turn demons – Li Ming's team revealed that tumor-associated macrophages use IRF8 to promote T cell depletion
Time of Update: 2022-11-15
The authors first detected changes in the mononuclear phagocyte system in the MMTV-PyMT (PyMT) breast cancer model, and found that the number of tumor-associated macrophages residing in tumor tissues increased, while the proportion of DC1 decreased, and DC2 did not change significantly。 Most DC1 expresses CD103, a marker associated with maturation and migration to secondary lymph nodes.
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TA that is easily misdiagnosed as asthma, have you ever learned?
Time of Update: 2022-11-14
02 heartCardiac involvement accounts for 50% of deaths in eosinophilic granulomatosis with polyangiitis, and eosinophilic infiltration and coronary vasculitis can cause pathologies such as acute constrictive pericarditis, heart failure, and mitral valve prolapse in myocardial infarction.
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Lupus nephritis ≠ chronic nephritis! Do you understand these differences?
Time of Update: 2022-11-14
[9]Write at the endIn short, whether it is lupus nephritis caused by lupus or chronic nephritis, it is a chronic kidney disease, and the treatment process is destined to be very long, if you want to rescue your kidneys to avoid them falling into haze, in addition to active treatment, patients also need to develop good living and eating habits, and integrate the precautions for kidney protection into daily life.
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With immune checkpoint inhibitors, beware of myocarditis! study
Time of Update: 2022-11-14
The investigators pointed out that in the near term after the application of immune checkpoint inhibitors, especially within 1 month, adverse cardiovascular events should be closely monitored, and once they occur, glucocorticoid therapy and even gamma globulin should be given in time according to the degree of the patient's condition, in order to prevent and reverse the progression of the disease at an early stage.
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Chinese scientists reveal a new pathogenesis of rheumatoid arthritis
Time of Update: 2022-11-14
This study is the first to find that the STAT3-NAV2 axis plays an important role in rheumatoid arthritis through the joint analysis of clinical samples, super enhancer sequencing, and basic experiments.
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Sjogren's syndrome is quick solution
Time of Update: 2022-11-14
Oral care and treatment of xerostomiaFor patients with xerostomia, smoking and drinking should be avoided, and drugs that cause aggravation of dry mouth such as atropine, phenothiazines, tricyclic antidepressants, antispasmodics, antiparkinsonians, and long-term use of H2 blockers including cimetidine, ranitidine and famotidine.
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High uric acid, these hazards should be careful!
Time of Update: 2022-11-14
3 Kidney disease3As we all know, the kidneys are the main metabolic organs of uric acid in the human body, and blood uric acid is at a relatively high level for a long time, which will increase the metabolic burden of the kidneys and even cause kidney damage.
