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Regarding the medication of osteoarthritis, you need to know at least these three points!

 Last Update: 2022-11-15
 Source: Internet
 Author: User

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Medication points, did you get it?

Osteoarthritis (OA) is a degenerative disease in which joint pain is the main symptom, and more women than men
are.
The prevalence of OA in people over 40 years old in China is as high as 46.
3%.

There are at least three things you need to know about the drug treatment of OA!

The three-step treatment

of OA 1, topical nonsteroidal anti-inflammatory drugs (NSAIDs)
are preferred.

The NSAIDs drugs in the medical insurance list include diclofenac diethylamine gel, ibuprofen cream, loxoprofen patch, flurbiprofen patch, etc
.

NSAIDs for topical use have less systemic absorption and few
side effects.

2.
When the effect of topical application is not good, combined with oral NSAIDs
.

NSAIDs (ibuprofen, loxoprofen, etoricoxib, etc.
) increase the high risk of cardiovascular events, using the lowest effective dose
for the shortest possible duration of treatment.

Patients with long-term, chronic, generalized pain and/or depression may also choose the anxiolytic drug duloxetine
.
Duloxetine has been approved by the FDA for chronic musculoskeletal pain
.

Simultaneous use of duloxetine with NSAIDs increases the risk of bleeding and is not recommended
.

3.
When the above treatment plan is not effective, intra-articular injection of corticosteroids
can be used with caution.

Intra-articular corticosteroid injections can provide rapid pain relief and improve joint function, but long-term repeated use carries the risk of
accelerating joint cartilage loss.

Intra-articular injection of corticosteroids, up to 2~3 times a year, the interval between injections should not be shorter than 3~6 months
.

Both drugs

can be tried1.
Although glucosamine
sulfate is no better than placebo in terms of effectiveness in treating knee and hip arthritis, it is safer and can still be used
as appropriate.

The 2022 edition of the "Osteoarthritis Diagnosis and Treatment Specifications" recommends glucosamine sulfate (500mg/time, 3 times/day).

It should be reminded that
glucosamine sulfate contains 151mg of sodium
per 1500mg.
Long-term use of large amounts may increase the risk of
hypertension, ischemic cardiomyopathy, heart failure and so on in the elderly.

If the symptoms do not improve after 3~6 months of use, treatment
should be discontinued.

2.
Joint injection of sodium
hyaluronate 2022 edition of the "Osteoarthritis Diagnosis and Treatment Specifications" believes that intra-articular injection of sodium hyaluronate can reduce pain, inhibit cartilage matrix decomposition, activate the cartilage tissue self-repair process, etc.
, for early and intermediate mild cartilage injury cases, or can relieve symptoms and improve function for a long time
For patients with mild to moderate OA, intra-articular injection of sodium hyaluronate, 2~3ml each time, once a week, 3~5 consecutive times
.

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