High uric acid, these hazards should be careful!

What is hyperuricemia?

Normally, the amount of uric acid production and excretion in the human body every day is about equal, and maintaining this balance will make uric acid values normal
.

And what we want to say about high uric acid is a disease
caused by problems in purine metabolism in the human body, resulting in imbalance in the concentration of uric acid in the blood.

According to the 2017 multidisciplinary expert consensus of hyperuricemia in China, under normal diet, the level of fasting blood uric acid > 420μmol/L twice on the same day can be diagnosed as hyperuricemia
.

Hazards of hyperuricemia

1 Cardiovascular disease

If high uric acid is allowed to develop, it will cause high blood pressure with a high
probability.
Studies have shown that hyperuricemia is one of the independent risk factors for hypertension, and the increase in blood uric acid concentration is positively correlated with the increase in vascular resistance in hypertensive patients, and the relative risk of hypertension increases by 23%
for every 59.
5μmol/L increase in blood uric acid.

Long-term hypertension will also affect uric acid metabolism through glomerular arteriosclerosis and other pathways, thereby aggravating hyperuricemia, and the two are causal and mutually reinforcing
.

In addition, elevated blood uric acid levels also indicate worsening
coronary heart disease.
Increased blood uric acid levels are accompanied by increased production of oxygen free radicals and participate in vascular inflammation, which can not only accelerate the atherosclerosis process, but also promote platelet aggregation and thrombus formation
.

2 Gout

Hyperuricemia and gout are continuous, chronic pathological processes, and the incidence of gout gradually increases
as blood uric acid levels increase.

The highest solubility of uric acid in the blood is 420μmol/L, beyond this value, monosodium urate crystals will be formed and deposited, thereby inducing local inflammation and tissue destruction, that is, gout
.
As the disease progresses, the joint inflammation will become more and more serious, and the frequency of pain will become higher and higher, seriously affecting the patient's normal daily life
.

According to clinical statistics, about 10% of patients with high uric acid will eventually develop gout
.

3 Kidney disease

As we all know, the kidneys are the main metabolic organs of uric acid in the human body, and blood uric acid is at a relatively high level for a long time, which will increase the metabolic burden of the kidneys and even cause kidney damage
.

If left untreated, it is likely that uric acid crystals will be deposited in the renal tubules, and over time, the risk of chronic renal failure and uremia will also increase
.
A small number of patients will also cause a transient increase in uric acid during an acute attack of gout, leading to acute renal failure, severe cases and even death
.

Renal insufficiency is an important risk factor for
hyperuricemia and gout.

4 Other risks

A large number of clinical studies have also shown that hyperuricemia can also cause diabetes, cerebral infarction, alcoholic and non-alcoholic fatty liver, cerebrovascular injury and other diseases
.

Prevention and treatment of hyperuricemia by traditional Chinese and Western medicine

At present, the main treatment is through early diet control and lifestyle adjustment, as well as the use of urate-lowering drugs
.

According to a certain uric acid value, we can divide hyperuricemia into three horizontal intervals (as shown in the figure above).

When blood uric acid is in stages 3 and 4 in the figure, it is necessary to use drugs to control uric acid
.

Western drugs that lower uric acid on the market are mainly divided into two categories: drugs that inhibit the production of uric acid, commonly allopurinol, febuxostat; Drugs that promote uric acid excretion, commonly phenbromarone
.

Although there is no record of "hyperuricemia" in Chinese medicine, the "gout" caused by the development of the disease to the middle and late stages belongs to the category of
"paralysis", "calendar", "white tiger disease" and other diseases of traditional Chinese medicine.
Zhu Danxi once described in "Gezhiyu Theory": "Gout, the limbs are painful.
.
.
White Tiger Calendar Wind Disease is also"
.

Chinese traditional Chinese medicine believes that uric acid is a harmful substance formed in the human body, similar to "turbidity", and its basis is spleen and kidney deficiency
.
Mainly due to poor diet, stress, sedentary and staying up late, etc.
, the liver, spleen, kidney and other organs are dysfunctional, resulting in the accumulation of wetness in the body and causing symptoms
.

In recent years, through a large number of clinical studies, the TCM community has taken the principle of dialectical treatment as the principle, combined with the specific conditions of patients, and used methods such as tonifying the kidney, strengthening the spleen, removing dampness, and removing stasis, which has shown good therapeutic results
.