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High uric acid, these hazards should be careful!
Time of Update: 2022-11-14
3 Kidney disease3As we all know, the kidneys are the main metabolic organs of uric acid in the human body, and blood uric acid is at a relatively high level for a long time, which will increase the metabolic burden of the kidneys and even cause kidney damage.
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Thrombopoietin receptor agonists (TPO-RA) and ITP therapy
Time of Update: 2022-11-14
Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder characterized by isolated peripheral platelet count reduction without a clear cause. Based on three large retrospectiv
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Pain, fatigue is SLE recurrence? It is also possible that this common disease is due
Time of Update: 2022-11-14
65% of people with SLE consider chronic pain to be the hardest part of the disease to face76% of people with SLE admitted that fatigue caused by lupus forced them to reduce their social activities89%
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Fibroblasts are essential for the development of cutaneous autoimmune diseases
Time of Update: 2022-11-14
On December 16, 2021, Chen Ting's research team from the Beijing Institute of Biological Sciences/Institute of Biomedical Interdisciplinary Research of Tsinghua University published a research paper entitled Anatomically distinct fibroblast subsets determine skin autoimmune patterns in the journal Nature, through single-cell transcriptome sequencing, mouse models and a series of genetic experimental methods.
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Hydroxychloroquine can reduce autoimmune hepatitis!
Time of Update: 2022-11-14
Lipid metabolism in T cells is controlled by HCQ: HCQ inhibits the activation of JAK2-STAT3-SOCS3 and promotes phosphorylation of AMPK in T lymphocytes:In summary, HCQ has a specific and effective therapeutic effect on autoimmune hepatitis and concomitant liver injury, which is attributed to HCQ acting on GRK2 translocation, inhibiting PI3K-AKT and inflammation-related JAK2-STAT3 signals related to T lymphocyte metabolism, thereby regulating lipid metabolism of T cell function to regulate T lymphocyte differentiation and function.
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Nature: West China Hospital reveals heterogeneity and plasticity of cancer-associated fibroblasts
Time of Update: 2022-11-14
The study performed pan-cancer analysis on 226 samples from 10 solid cancers to analyze TME at single-cell resolution, revealing commonality/plasticity of heterogeneous CAFs. https://doi.
The study performed pan-cancer analysis on 226 samples from 10 solid cancers to analyze TME at single-cell resolution, revealing commonality/plasticity of heterogeneous CAFs. https://doi.
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Arthritis Res Ther: efficacy and safety of Guselkumab and Adalimumab in the treatment of pustular osteitis and their effect on peripheral blood immunophenotype
Time of Update: 2022-11-14
Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes Arthritis Res Ther 2022 Oct 27; 24(1) Background: Palmoplantar impetigo (PPP) is a chronic, recurrent inflammatory skin disease characterized by the appearance of aseptic pustules following the formation of erythema and scaly vesicles locally on the palms and soles of the feet.
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Chinese Translation 2021 ACR Guidelines: COVID-19 Vaccination for Patients with Rheumatic and Musculoskeletal Conditions (3rd Edition)
Time of Update: 2022-11-14
Guide Name: [Chinese translation] 2021 ACR Guidelines: COVID-19 vaccination in patients with rheumatic and musculoskeletal disorders (3rd edition)American College of Rheumatology Guidance for COVID-19
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Sudden dizziness, headache: rheumatoid patients must know about the involvement of the disease
Time of Update: 2022-11-14
It may seem that it is very difficult to completely prevent, but if cervical symptoms have already appeared, how can we treat it?Early treatment is keyTreatment of rheumatoid involvement of the cervical spine includes surgery, medication, and traditional Chinese medicine.
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These two kinds of pain are inseparable! Why is fibromyalgia always accompanied by headaches?
Time of Update: 2022-11-14
From the lifestyleStress and lack of sleep can make fibromyalgia and headaches worse, and controlling some of the workload and avoiding the so-called 996 and 007 can better manage life and reduce feelings of depression and anxiety.
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Lupus patients can't hide from fatigue? Wait, why not try these 4 methods!
Time of Update: 2022-11-14
The combination of moderate exercise, reasonable diet, sleep intervention, and mental adjustment can effectively help SLE patients relieve fatigue, control their condition, and improve their quality of life.
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Hydroxychloroquine protects against placental injury in obstetric antiphospholipid syndrome
Time of Update: 2022-11-14
OAPS placental pattern diagram for HCQ-treated: Therapeutic effects of HCQ in APS animal models:After collecting clinical data to determine the therapeutic effect, human trophoblast cells in the first trimester of pregnancy were prepared and treated with aPL.
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Can people with rheumatoid arthritis stop their medications?
Time of Update: 2022-11-14
Rheumatoid arthritis (RA) is a chronic autoimmune disease that requires long-term treatment with disease-modifying anti-rheumatic drugs (DMARDs). The key goal of treatment for RA is to achieve clinica
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Care measures for secondary osteoporosis in patients with rheumatism
Time of Update: 2022-11-14
3, increase light irradiation to supplement calcium, sunlight can promote the production of active vitamin D in the body, improve the absorption rate of calcium, so as to prevent the occurrence of osteoporosis, we recommend that after 4 pm to evening every day, sunbathing 20-30 minutes is appropriate, but should vary from person to person, to avoid excessive sun exposure caused by sunburn, according to the weather can be adjusted.
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Ribosome pause + protein imbalance, time this "pig-killing knife"!
Time of Update: 2022-11-14
A model of increased ribosome pause and nascent peptide aggregation during aging (Source: Nature)In conclusion, this study links ribosome pause in the aging process with co-translational transport and protein homeostasis, and proves that the increase of pause will lead to RQC overload of nascent polypeptide aggregation, disrupt protein homeostasis, and play an important role in aging-induced systemic decline.
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Prairie Medical Talk: How to avoid hyperuricemia from developing into gout?
Time of Update: 2022-11-14
： ， 。 ， ， The rheumatology and immunology outpatient of the hospital has two patients: Xiao Wang's blood uric acid value is 558umol/L, but the doctor said that he is not gout but hyperuricemia.
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Can systemic lupus erythematosus eat seafood?
Time of Update: 2022-11-14
For patients with systemic lupus erythematosus combined with "lupus nephritis", because their kidneys are damaged, a large intake of protein-rich seafood will burden the patient's kidneys!In addition to seafood, some warm meats, such as beef, mutton, dog meat, venison, horse meat, donkey meat, etc.
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Mechanisms of acquired resistance to immune checkpoint inhibitors
Time of Update: 2022-11-14
Mechanisms of ICI-acquired resistanceAlthough many cases have uncertain or unknown mechanisms, the resistance mechanisms of ICI can be broadly divided into the following categories: 1) defects in antigen presentation mechanisms; 2) IFN-γ signal path defects; 3) loss of neoantigens; 4) tumor-mediated immunosuppression; 5) Other suppression checkpoints.
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Express prevents multiple sclerosis progression for nearly four years! T cell therapy has shown excellent results
Time of Update: 2022-11-05
▎WuXi AppTec content team editor Atara Biotherapeutics has updated new advances in its Phase 1 clinical trial of ATA188, an allogeneic T-cell immunotherapy targeting Epstein-Barr virus (EBV), in progressive multiple sclerosis, including new magnetic resonance imaging (MRI) biomarkers and open-label extension (OLE) trial data.
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Express 98.6% reduction in recurrence risk! AstraZeneca's Phase 3 clinical results for autoimmune disease therapy are impressive
Time of Update: 2022-11-05
▎WuXi AppTec content team editorToday, AstraZeneca announced positive results from a Phase 3 clinical trial of Ulomiris (ravulizumab), a long-acting complement C5 protein inhibitor developed by its subsidiary Alexion, in the treatment of neuromyelitis optica spectrum disease (NMOSD).
