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Be the first to see! ACR/EULAR revised mitigation criteria for RA
Time of Update: 2022-11-05
New standards have appeared!The following quantitatively validated study using independent patient data also suggests that increasing the PGA standard threshold from 1 to 2 results in more patients being defined as Boolean remission and increasing its agreement with SDAI response criteria without compromising its predictive value for imaging or functional outcomes.
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Patient Research Tips: Gut Bacteria Stimulate Autoimmunity in Rheumatoid Arthritis|Science and Translational Medicine
Time of Update: 2022-11-05
" ”Welcome to pay attention to the official scientific public account and click "Read Original" to visit the original English text to light up your "like" for medical researchClick on the blue words above to follow usA new study involving mice and 6 patients with rheumatoid arthritis or at high risk showed that a bacterium found in the gut microbiome may contribute to the formation of harmful autoimmune antibodies in the early stages of rheumatoid arthritis.
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Despite the diagnosis of rigidity, rheumatologists should not ignore these two conditions!
Time of Update: 2022-11-05
*For medical professionals onlyStill have to think more~Synopsis: A 29-year-old woman presents with "lower limb discomfort with low back pain for 10 years and polyarticular pain for 3 months". The pat
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Eur J Med Res: Icariin alleviates osteoarthritis via the PI3K/Akt/mTOR/ULK1 signaling pathway
Time of Update: 2022-11-04
Results: IL-1β increased MMP-3 overproduction, induced type II collagen degradation, and decreased levels of autophagy-related proteins, including ULK1, Beclin-1, and LC3-II/I.
Results: IL-1β increased MMP-3 overproduction, induced type II collagen degradation, and decreased levels of autophagy-related proteins, including ULK1, Beclin-1, and LC3-II/I.
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How to detect systemic lupus erythematosus early
Time of Update: 2022-11-04
LeadLupus erythematosus is not without traces, persistent fever, hair loss, joint pain, facial erythema is often an early manifestation of lupus, when the above symptoms occur, you must be vigilant and seek medical attention in time.
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Do you know what these joint examinations need to be done for rheumatic patients?
Time of Update: 2022-11-04
In the process of treatment, joint ultrasound examination can also help doctors predict the efficacy and imaging progress of drugs, so that doctors can more accurately understand disease activity, closely monitor disease changes, evaluate efficacy and judge prognosis, providing an important basis for formulating reasonable rheumatoid treatment plans.
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Gut(IF=32) Peng Hua/Tsinghua University of Chinese Academy of Sciences Fu Yangxin discovered a potential new method to disrupt HBV immune tolerance
Time of Update: 2022-11-04
Anti-PDL1-IFNα heterodimer combined with hepatitis B surface antigen inoculation produces functional cure in HBV-carrying mice (Figure from Gut) The authors took advantage of the high expression of PDL1 in the liver of CHB patients and chronic HBV-carrying mice to target IFNα with anti-PDL1-IFNα and PDL1 and type I IFN receptors (IFNAR) in the liver, Thus overcoming PDL1-mediated local resistance and virus production.
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Instructions for safe use of pregnant women with lupus erythematosus
Time of Update: 2022-11-04
SLE patients are pregnant to meet certain conditions, first of all, they must be stable for at least half a year and have no important organ damage, followed by stopping immunosuppressants such as methotrexate and leflunomide for at least half a year or more, and using hormones in small doses.
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The role of neutrophils in autoimmune diseases
Time of Update: 2022-11-04
Recent studies have found that neutrophils, especially the extracellular traps released after neutrophil activation, play a central role in the development and persistence of systemic autoimmune diseases.
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Nat Immunol Qi Hai/Wang Jianbin of Tsinghua University collaborated to reveal plasma cell responses to immunity, autoantigens and microbiota
Time of Update: 2022-11-04
On October 31, 2022, Qi Hai of Tsinghua University and Wang Jianbin jointly published a joint newsletter entitled "Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota" online in the journal Nature Immunology Through single-cell mRNA sequencing, cytology, and genetic pulse-chasing mouse models, the study found that IgG and IgM LLPCs showed the EpCAM hi CXCR3- phenotype, while IgA LLPCs were Ly6AhiTigit-.
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20 frequently asked questions by patients with systemic lupus erythematosus
Time of Update: 2022-11-04
1What is the incidence of SLE?The age of onset of the disease is mostly in young adults, and women are far more than men, the ratio of men and women is 1:7~10, and women of childbearing age account fo
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Rational use of colchicine, NSAIDs, glucocorticoids in gout
Time of Update: 2022-11-04
Low-dose NSAIDs are recommended as second-line agents for the prevention of gout attacks in patients who are intolerant to colchicine.
Low-dose NSAIDs are recommended as second-line agents for the prevention of gout attacks in patients who are intolerant to colchicine.
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Summary of clinical manifestations of Sjogren's syndrome
Time of Update: 2022-11-04
Chinese Journal of Internal Medicine, 2020, 59(4): 269-276 pages Sjogren's syndrome (pSS) is a chronic inflammatory autoimmune disorder characterized by lymphocyte proliferation and progressive exocrine gland damage, in which a variety of autoantibodies are present in the blood serum.
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The man behind thrombocytopenia in lupus patients
Time of Update: 2022-11-04
Therefore, in clinical practice, hormones and intravenous immunoglobulin are generally used in early stage for lupus patients with disease activity and thrombocytopenia to inhibit the production of platelet antibodies and their binding to platelet membranes and avoid platelet destruction.
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This article explains the side effects of rheumatoid drugs, and 6 methods are effective in alleviating them
Time of Update: 2022-11-04
"Doctor, taking so many medicines, will the side effects of the drugs be great?"Doctor, how can I make these drugs have fewer side effects? ”As we all know, rheumatoid is a disease with a long course
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Case analysis of systemic sclerosis
Time of Update: 2022-11-04
Systemic sclerosis (SSc) is a rare disease common in rheumatology and immunology, also known as scleroderma, which is a chronic connective tissue disease characterized by localized or diffuse skin thi
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Accidentally! Gout, arthritis, what to eat does not affect joint health? An authoritative panel of experts publishes the latest evidence
Time of Update: 2022-11-01
Figure 1: Summary of rheumatoid arthritis results (Translation source: Reference [1]) 2 OsteoarthritisThere were few dietary studies related to osteoarthritis, with moderate evidence from fish oil, chondroitin, glucosamine, vitamin D and avocado soy unsaponifiable (ASU), but the outcome effect size was small and therefore not clinically relevant.
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After initial biologic therapy failure, rheumatoid arthritis medication needs to consider "two strategies, nine types of factors" The latest review said
Time of Update: 2022-11-01
If treatment with a second TNF inhibitor fails, EULAR guidelines recommend that patients be treated with therapeutic drugs with different mechanisms of action.
If treatment with a second TNF inhibitor fails, EULAR guidelines recommend that patients be treated with therapeutic drugs with different mechanisms of action.
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What are the risk factors for developing discoid lupus erythematosus into severe lupus?
Time of Update: 2022-11-01
Conclusion outlookThe cohort of this study showed that risk factors for developing sSLE included: age at diagnosis of DLE< 25 years, phototyping V.
Conclusion outlookThe cohort of this study showed that risk factors for developing sSLE included: age at diagnosis of DLE< 25 years, phototyping V.
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The latest research progress of post-translational modification of natural immune signaling pathways in Yin Hang's research group of Tsinghua University in 2022
Time of Update: 2022-11-01
▎WuXi AppTec content team editor Natural immunity is the body's "first line of defense" against pathogen invasion. When a pathogen invades, the molecular patterns associated with the pathogen are reco
