-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
▎WuXi AppTec content team editor
Rheumatic and musculoskeletal diseases (RMDs) are a collective term for a series of diseases, such as rheumatoid arthritis (RA), osteoarthritis (OA), axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), gout, etc.
, which are one of the important factors of
disability.
Previous studies have found that lifestyle changes can help reduce the risk of developing certain chronic diseases, but it is unclear whether they also benefit the outcomes
of people with RMDs.
In 2018, the European Alliance Against Rheumatism (EULAR) established a task force to focus on the impact of 6 lifestyles (diet, exercise, weight, drinking, smoking, work) on the above 7 common RMDs diseases, as well as make relevant recommendations
based on the latest clinical evidence-based medical evidence.
Recently, the RMD OPEN journal of the British Medical Journal (BMJ) published a meta-analysis of the impact of dietary factors on the outcome of RMDs patients, in order to provide reference for the working group, the results of the meta-analysis show that some specific additives and food components can play a limited role in improving the symptoms of RMDs patients, such as pain, joint function, joint stiffness, etc.
However, due to the lack of high-level clinical evidence, dietary recommendations cannot be made on the results of the current study
.
This meta-analysis selected 174 articles on diet and RMDs published between 1 January 2013 and 18 September 2018, including 24 reviews and 150 research papers
.
The evidence included in the analysis came from three databases
: Medline, Embase, and Cochrane Library.
1
Rheumatoid arthritis
The evidence from dietary studies related to rheumatoid arthritis was generally low, with only probiotics, vitamin D, and fish oil/omega-3 being moderate, but these ingredients were not effective or limited in rheumatoid arthritis to be considered clinically valuable
.
2
Osteoarthritis
There were few dietary studies related to osteoarthritis, with moderate evidence from fish oil, chondroitin, glucosamine, vitamin D and avocado soy unsaponifiable (ASU), but the outcome effect size was small and therefore not clinically relevant
.
Figure 2: Summary of osteoarthritis results (Translation source: Reference [1])
3
Systemic lupus erythematosus
Fish oil/omega-3 has a moderate effect on systemic lupus erythematosus, but does not affect patient outcomes, and evidence from other dietary studies is low or very low
.
4
Psoriatic arthritis, axial spondyloarthritis
Dietary evidence from axial spondyloarthritis was low or very low
.
Evidence for psoriatic arthritis was moderate only with marine animal oil/omega-3, and evidence from other dietary studies was low or very low
.
Fig.
4: Summary of results of psoriatic arthritis and axial spondyloarthritis (Translation source: Reference [1])
5
Systemic sclerosis, gout
Evidence from all dietary studies in systemic sclerosis, gout was low or very low
.
Figure 5: Summary of results of systemic sclerosis and gout (Translation source: Reference [1]).
Overall, diet has little effect on outcomes in patients with rheumatoid arthritis, osteoarthritis, axial spondyloarthritis, psoriatic arthritis, systemic lupus erythematosus, systemic sclerosis, and gout, and there is no high-level clinical evidence-based medical evidence, and dietary opinions and recommendations
cannot be made on the results of the current study.
However, it is still important to maintain a healthy, balanced diet and a reasonable weight in your daily life:
1) Eat a healthy, varied diet: Eat more omega-3-rich foods, such as tuna, sardines, foods high in vitamin D, such as eggs, milk, etc.
, while maintaining a balanced intake
of fruits, vegetables, legumes, whole grains and other foods.
2) Avoid alcohol: Drinking alcohol may increase the risk of
diseases such as gout and rheumatoid arthritis.
3) Maintain a reasonable weight
.