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Do a good job in CVD risk management of RA patients, it is important to choose the right drug!
Time of Update: 2022-09-15
Comparative Risk of Cardiovascular Events With Biologic and Synthetic Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis[J].
Comparative Risk of Cardiovascular Events With Biologic and Synthetic Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis[J].
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Immune Cell Research Guide: How B Cell Markers Are Selected
Time of Update: 2022-09-14
An overview of the major subtypes of B cells (image from Biocompare)Marker of B cell developmentMost B cells develop in the bone marrow (BM), followed by maturation in secondary lymphoid organs and eventually circulate in the bloodstream.
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Cytotoxic immunosuppressants commonly used in the treatment of SLE
Time of Update: 2022-09-14
In patients with refractory (poor treatment with conventional therapy) or recurrent SLE, the use of immunosuppressants reduces the amount of hormones used, controls disease activity, and improves clinical response rates.
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NEJM: Therapeutic effect of anti-BDCA2 antibody Litifilimab on systemic lupus erythematosus (LILAC study)
Time of Update: 2022-09-14
5 。 An analysis of the revised primary endpoints at week 24 (Table 2 and Figure 1) showed that the absolute change in mean least squares (±SE) in the total number of active joints compared to baseline in the litifilimab group was –15.
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Adv Sci: Professor Li Zhanguo's team found that the tonsil flora can regulate host immunity and fight rheumatoid arthritis
Time of Update: 2022-09-14
Figure: Tonsillar microbiome-derived wool sulfur antibiotic peptide sialic acid is defective in patients with RA and is associated with circulating immune cells.
Figure: Tonsillar microbiome-derived wool sulfur antibiotic peptide sialic acid is defective in patients with RA and is associated with circulating immune cells.
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A&R: Total transcriptomics analysis identifies differential gene expression characteristics between inflammatory and non-inflammatory aortic aneurysms
Time of Update: 2022-09-14
ObjectiveTo identify marker genes and biomolecular processes of aortitis using high-throughput gene expression profiles, and to provide a range of potential new drug targets (genes) and therapeutic methods through pharmacogenomic network analysis.
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Common clinical problems with biologics DMARDDs treatment regimens
Time of Update: 2022-09-14
What are biologics DMARDS?Biologics DMARDDs are targeted therapeutic drugs that target immune cells or cytokines, have good specificity, and are effective drugs to achieve standard treatment 。 Biological agents mainly include: (1) anti-tumor necrosis factor biological agents (TNF-α inhibitors): adalimumab, infliximab, etanercept, etc.
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1 in 10 people! Asymptomatic high uric acid, do not be careless
Time of Update: 2022-09-14
Patients with uric acidemia have a 95% higher risk of developing diabetes than those with normal blood uric acid!In addition, it has been found that hyperuricemia is related to the occurrence of lipid metabolism disorders such as obesity, hypertriglycerides, and hypercholesterolemia.
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Correct use of glucocorticoids in rheumatism
Time of Update: 2022-09-14
5 mg/day and planned to continue treatment for more than 3 months, it is recommended to give calcium supplementation and vitamin D at the same time as starting hormone use; For patients at high risk of fracture, the addition of bisphosphonates is recommended to prevent osteoporosis.
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Colchicine is a first-line medication for gout patients, but it is in mortal danger, and it is necessary to be cautious when taking the drug!
Time of Update: 2022-09-14
： ， 。 Video Applet Like, double tap to cancel Like in Watch, tap twice to cancel Watch When it comes to colchicine, gout with hyperuric acid is certainly not unfamiliar.
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Lymphatic migration of Immunity unconventional T cells promotes site-specific immunity in different lymph nodes
Time of Update: 2022-09-14
Overall, using LN transplantation, single-cell sequencing, spectral flow cytometry, and fluorescence-reported transgenic mouse models, the researchers elucidated UTCs migrating to localized drainage LNs via lymphatic pathways, each with a unique tissue-determined combination of UTCs. Through a single mouse model of UTC deficiency, UTC was found to function in interconnected units, producing a characteristic site-specific immune response.
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Cell Host & Microbe Xia Ningshao team reveals a new mechanism of antibody cocktail therapy
Time of Update: 2022-09-10
On August 23, 2022, the team of Professor Xia Ningshao of Xiamen University published an article Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail on Cell Host & Microbe .
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The top journal of immunology tells you: T cell exhaustion is worth digging into
Time of Update: 2022-09-09
Overview01Knowledge sharing about T cell depletion02Must-read classic articles on T cell depletion03Statistics of the top journal of T cell depletion immunologyPersonalized bioinformatics ideas for T
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Repeated eye inflammation, beware of these 7 kinds of rheumatism!
Time of Update: 2022-09-09
It is the most common ocular manifestation of rheumatism, and uveitis is classified into anterior, intermediate, posterior, and panuveitis according to the anatomy of the inflammation (Figure 1) .
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High uric acid, gout, these 4 conditions must be treated with lowering uric acid, so choose the drug
Time of Update: 2022-09-09
What about the control goals?It is recommended that patients with asymptomatic hyperuricemia initiate uric acid-lowering drugs when:Blood uric acid level ≥ 540 μmol/L;Blood uric acid levels ≥ 480 micromol/L and have one of the following comorbidities: hypertension, abnormal lipid metabolism, diabetes mellitus, obesity, stroke, coronary heart disease, cardiac insufficiency, uric acid nephrolithiasis, renal impairment (≥ CKD stage 2).
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STTT (IF=38) Sichuan University Li Weimin/Zhang Li/Wang Chengdi reveal the heterogeneous immune landscape between lung adenocarcinoma and squamous cell carcinoma
Time of Update: 2022-09-09
Single-cell RNA sequencing (scRNA-seq) technology has given researchers the opportunity to dissect the different immune signatures between the two main subtypes of NSCLC, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) .
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If you don't want kidney crystals to develop into kidney stones, please keep the 5 treatment suggestions!
Time of Update: 2022-09-09
▌ Increase your intake of fruits and vegetablesIncrease the intake of fruits and vegetables, especially those rich in potassium, because the organic anions they provide are metabolized into alkaline substances in the body, effectively neutralizing the acid of animal proteins, while reducing high levels such as cola The intake of sugary drinks can reduce the formation of uric acid stones .
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Good news for psoriasis patients!
Time of Update: 2022-09-09
Study finds that this common amino acid is actually related to depression | Gut Jun WeeklyLearn a piece of knowledge and keep a piece of health ▼ Gut Jun Weekly [DrGut]▼ The knowledge feast in the field of intestinal bacteria medicine gives time to readingIssue 230 | Gut Jun WeeklyPsoriasis, Streptococcus salivarius K-12; alcohol, acetate; dietary cholesterolOriginal: Improvement of Psoriasis Using Oral Probiotic Streptococcus salivarius K-12: a Case-Control 24-Month Longitudinal Study.
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First disclosure: Sjogren's syndrome coexists with these two diseases at the same time, and clinical vigilance is required
Time of Update: 2022-09-09
This case highlights the underlying lung manifestations of Sjögren's syndrome, as well as the organ involvement and disease associations that LIP and LCDD may cause.
This case highlights the underlying lung manifestations of Sjögren's syndrome, as well as the organ involvement and disease associations that LIP and LCDD may cause.
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Toothaches can cause and aggravate rheumatoid arthritis, and this bacteria is involved!
Time of Update: 2022-09-09
*For medical professional reading reference onlyClinical knowledge points that rheumatologists cannot missThe People's Health Publishing House "Oral Science 9th Edition" clearly stated that periodontitis may cause and aggravate rheumatoid arthritis (RA), which may be related to the periodontitis bacteria prompting the immune system to produce anti-CCP antibodies.
