The top journal of immunology tells you: T cell exhaustion is worth digging into

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Ly108 and CD69 molecular signatures define 4 Tex stages during T cell depletion

• Exhaustion progenitor 1 (T cell Exhaustion progenitors, Tex Prog1): Ly108+, resting state, local resident tissue;
• Exhaustion progenitors 2 (T cell Exhaustion progenitors 2, Tex Prog2): Ly108+, enter the proliferation, with the ability to enter the blood;
• T cell Exhaustion intermediate (TexInt): Tex Prog2 gradually loses TCF1, divides and switches to the third stage, and exhausted T regains some cytotoxic effector functions, especially after PD-L1 blockade;
• T cell Exhaustion terminally (Tex Term): exhausted T cells with high expression of PD-1 eventually enter the terminal phase and no longer respond to PD-L1/PD-1 blockade;

Ref: 32396847; Immunity; IF43

Consequences of T cell depletion T cell depletion is a major obstacle to current anticancer immunotherapy

How to curb T cell exhaustion Immune checkpoint inhibitors can reverse the T cell exhausted state.

Must-read classic articles on T cell depletion

2.
Epigenetic regulation of T cell depletion: T cell depletion leads to overall epigenetic remodeling that confer phenotypic stability to these cells and prevent T cell reactivation through checkpoint inhibition
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Review elucidates the developmental and epigenetic regulation of exhausted T cells, as well as the functional impact of viral infection, cancer, autoimmunity and engineered T cell therapy
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Research Article 1.
Four stages of T cell exhaustion: scientists from research units such as the University of Pennsylvania and Kanazawa University in Japan published an article in Immunity: Expounding the developmental framework of the four stages of T cell exhaustion and the molecular characteristics of each stage (must read)

2.
T cell exhaustion reversal marker discovery: A study published by Cui Guoliang's team at Heidelberg University in Germany in Science Immunology, a top journal in immunology, found that the expression of Rgs16 can mark a terminally differentiated subset of T cells that have lost their T cell stemness.
and decreased responsiveness to PD-1 blockade
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Therefore, inhibiting the expression or function of Rgs16 may provide a potential interventional pathway for enhancing anti-tumor CD8+ T cell survival and anti-tumor effect
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Statistics of T Cell Exhaustion Top Journal of Immunology Of course, there are still many articles about T cell exhaustion.
The editor focuses on the number of relevant research publications in the top immunology journals.
It can be seen that the top immunology journals are favored by the direction of T Cell Exhaustion.
Yes, after all, following the big guys to go to the hot spot is designated to take care of it! Conclusion T cell depletion obviously plays an important role in tumor immunity, infection immunity, and autoimmunity
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The PMID32396847 work found that T cells in the middle stage of exhaustion responded best to immune checkpoint inhibitor treatment and were able to restore the cytotoxic function of T cells
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Therefore, companion diagnostics (such as Tex Int ratio) based on T cell exhaustion staging (or exhausted T cell subtypes) should play a positive role in better exerting the effect of immune checkpoint inhibitor therapy
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T-cell depletion research is a key point in the intervention of various vaccines and targeted therapy drugs.
It has always been a multiple hot spot in top journals, fund funding, clinical research, and drug development and marketing.
It is definitely right to pay attention to the hot spots
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The editor will continue to share the entry point of T Cell Exhaustion with you tomorrow.
Fans who want to know in advance how T cell exhaustion can generate letters should hurry up!

Personalized bioinformatics ideas for T cell depletion

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