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Why don't immune cells attack gut microbes? Nature reveals key clues!
Time of Update: 2022-09-21
In a new study published in Nature on September 8, Beijing time, a research team from Cornell University's Weill Cornell School of Medicine found that a class of congenital lymphocytes plays an important role in establishing tolerance to symbiotic microorganisms in the human gastrointestinal tract.
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The Nature retrofit element Lx9 regulates the immune response to viral infections
Time of Update: 2022-09-21
Next, the researchers used CRISPR-Cas9 to construct a usable mouse model of Lx9c11 deletion, and on the fourth day after CVB4 infection, RNA-seq analysis confirmed a reduction in host transcription in Lx9c11-/-mice, and reduced expression of L1_Mus3 on nearby LINE-1, or chromosome 11.
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Directly attack the clinical pain points of SpA, improve the level of diagnosis and treatment, and "go to the future" together!
Time of Update: 2022-09-21
”A three-pronged approach to improving the status quoTowards the future plan will be in view of the pain points and difficulties in the clinical diagnosis and treatment of SpA in China, Professor Zeng Xiaofeng said that the "To the Future" project mainly carries out three major sections of work:Establish a standardized diagnosis and treatment center to promote the development of standardized diagnosis and treatment of rheumatology and immunology in the country.
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Clinically encountered knee joint pain, the article summarizes the most complete causes
Time of Update: 2022-09-21
So what are some common diseases that can cause damage to the structure of the knee joint?Source of this article: Rheumatic Immunity Channel of the Medical CommunityThis article is organized: Mo intoThis article is reviewed: Chen Xinpeng, Deputy Chief PhysicianEditor-in-charge of this article: Orange
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Woman has been bedridden for 36 years due to rheumatism! And at the age of 6, he was diagnosed...
Time of Update: 2022-09-21
The 2019 International Experimental Organization for Children's Rheumatology (PRINTO) proposed a new typing standard for JIA[3], changing the age classification standard of JIA from 16 years old to 18 years old, deleting the 2001 ILAR proposed oligoarticular JIA, RF-positive polyarticular JIA, RF-negative polyarticular JIA and PsA, and adding RF-positive JIA, Early-onset ANA-positive JIA (Table 1).
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Want to predict lymphoma risk in patients with Sjogren's syndrome? This indicator is important!
Time of Update: 2022-09-21
Download the Doctor Station App and subscribe anytime, anywhere*For medical professionals onlyClinical information, 1s reach ▎ Clinical question: Can accurate records of parotid swelling (PSW) predict non-Hodgkin lymphoma (NHL) in primary Sjögren syndrome (pSS)?
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Dysbiosis of the gut microbiota can trigger autoimmune diseases, and the tonsil flora is no exception
Time of Update: 2022-09-21
In conclusion, the study reveals the immunomodulatory role of Salivaricin in autoimmune diseases, demonstrating that it beneficially regulates host immunity by directly binding to and inhibiting IL-6 and IL-21 receptors.
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First reported: Sjogren's syndrome coexists with such conditions, and this test is key to diagnosis
Time of Update: 2022-09-21
Magnetic resonance angiography (MRA) does not see the common carotid artery, sees collateral vessels, these results are consistent with TAK; Therefore, FDG-PET/CT examination shows that the blood accumulation of the ascending aorta to the descending aorta is increased, and the descending aortic stenosis is found.
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AdTp: elastin-like polypeptide enhancement adeno-associated virus in Zongchao Han's research group at the University of North Carolina is expressed under pre-storage neutralizing antibody conditions
Time of Update: 2022-09-21
In view of this, the above immunogenic residues can be avoided by various ways to avoid the human immune response may improve the efficiency of gene therapy for some genetic diseases.
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The team of Fan Xiaoyong of MedComm Fudan University published an article: A review of the yin-yang balance of trained immunity and its application prospects
Time of Update: 2022-09-21
A team of researchers fan Xiaoyong of Shanghai Public Health Clinical Center affiliated to Fudan University published a review entitled Trained immunity: A Yin‐Yang balance in MedComm issued by Wiley, which systematically summarized the discovery process, research model, induction process and regulatory mechanism of training immunity, and proposed for the first time that the impact of training immunity on human health is in line with the ancient Chinese philosophical idea "Yin and Yang Theory".
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From "fighting alone" to "fighting together", traditional medicines synergize
Time of Update: 2022-09-21
Efficacy and safety comparison of Ellamod or leflunomide combined with methotrexate in the treatment of active rheumatoid arthritis: a multicenter, randomized, double-blind, double-analog-controlled clinical study[J].
Efficacy and safety comparison of Ellamod or leflunomide combined with methotrexate in the treatment of active rheumatoid arthritis: a multicenter, randomized, double-blind, double-analog-controlled clinical study[J].
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For RA patients with poor efficacy of traditional drugs, where will the follow-up treatment go?
Time of Update: 2022-09-21
The drug treatment of RA has experienced a large variety of biological DMARDs (bDMARDs) and targeted DMARDs (tsDMARDs) from the clinical application of traditional disease-modifying anti-rheumatic drugs (csDMARDs) that change the course of the disease to the present.
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Heavy! 2022 NICE Gout Guidelines Released (FlowChart Included)
Time of Update: 2022-09-21
*For medical professionals onlyExclusive flowchart, hurry up and collect!Gout is a long-term disease, in which an increase in serum uric acid levels leads to the formation of uric acid monosodium crystals, which leads to severe joint pain and inflammation, recurrent attacks and progressions of gout and chronic arthritis.
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Additional use of hydroxychloroquine increases live birth rates in women with persistently positive antiphospholipid antibodies
Time of Update: 2022-09-19
In previous studies, treatment with low-dose aspirin and therapeutic-dose heparin in patients with APS was associated with higher live birth rates (mean 79% of pregnancies) .
In previous studies, treatment with low-dose aspirin and therapeutic-dose heparin in patients with APS was associated with higher live birth rates (mean 79% of pregnancies) .
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A case of alopecia universalis with hyperthyroidism treated with azathioprine and hydroxychloroquine
Time of Update: 2022-09-19
About a month after stopping steroids and adding azathioprine and hydroxychloroquine, she started improving with hair growth in the scalp area .
About a month after stopping steroids and adding azathioprine and hydroxychloroquine, she started improving with hair growth in the scalp area .
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The disease is difficult to control, hormones are difficult to reduce, how to break through the RA treatment dilemma?
Time of Update: 2022-09-15
How should the treatment options be chosen for such patients?Click [Read the original], learn more content now, full of dry goods, not to be missed!The case has been informed by the patient.
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Do you know all the 16 details of gout medication?
Time of Update: 2022-09-15
Therefore, patients must pay attention to drinking more water (more than two liters per day) during the period of taking such drugs to increase the amount of urine, promote the excretion of uric acid, and avoid the formation of urate crystals.
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Rheumatology regulates the use of cyclophosphamide, these five points to know!
Time of Update: 2022-09-15
Combined with the latest review and expert consensus, this paper focuses on the structural mechanism of action of cyclophosphamide in rheumatic diseases, clinical indications, adverse drug reactions, measures and precautions for reducing toxic side effects.
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This disease is extremely easy to distinguish from 4 types of rheumatism! But the director saw through it at a glance...
Time of Update: 2022-09-15
In this case, the patient's serositis, elevated blood picture, elevated inflammatory indicators and other manifestations are very similar to AOSD, but the patient does not have fever and arthritis, ANA is also positive, plus the lymph node biopsy of AOSD is characterized by chronic nonspecific inflammation or reactive hyperplasia, which is inconsistent with this case, so the director rejected the diagnosis of AOSD.
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Single joint pain is not rheumatoid? There are times when "standards" go wrong...
Time of Update: 2022-09-15
Recently, a case of single-joint rheumatoid arthritis of the elbow confirmed by synovial tissue biopsy in middle-aged women was reported on BMJ Case Reports.
Recently, a case of single-joint rheumatoid arthritis of the elbow confirmed by synovial tissue biopsy in middle-aged women was reported on BMJ Case Reports.
