-
Rheumatism that will "rot the face", never forget it after reading it
Time of Update: 2022-10-01
The etiology of this disease is not yet clear, the lesions often involve the skin, bones and joints, the course of the disease is prolonged, clinically characterized by intermittent recurrence and remission, more likely to occur in young and middle-aged age, skin lesions are characteristic, including palmoplantar pustules, pustular psoriasis, cluster acne, fulminant acne and purulent hidradenitis.
-
The risk of heart failure in people with systemic sclerosis is significantly increased, and more than 10,000 studies have confirmed...
Time of Update: 2022-10-01
Download the Doctor Station App and subscribe anytime, anywhere*For medical professionals onlyClinical information, 1s reach ▎Clinical Questions: What is the risk of clinical heart failure (HF) with accompanying symptoms in patients with systemic sclerosis (SSc)?
-
Nature Immunology Li Huabing/Wu Yuzhang/Yi Chengqi et al. reveal the mechanism by which tRNA m1A modification promotes the amplification of T cells
Time of Update: 2022-10-01
The study shows that when exiting from the resting state, T cells up-regulate the transport RNA (transfer RNA, tRNA) m1A58 encoder proteins TRMT61A and TRMT6, which conferm1A58RNA modifications on a specific subset of early expression tRNA.
-
Moderate starvation when sick can enhance immune cell activity
Time of Update: 2022-10-01
When T cells (blue-white spheres) are filled with energy in the form of ketone bodies (blue), they can fight viruses more effectivelyKetone bodies make the immune system strongerHopefully there will be new treatment optionsReference: Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19Source: Biocom
-
Glucocorticoids for the treatment of rheumatoid arthritis, Professor Zhang Zhuoli introduced in all aspects
Time of Update: 2022-10-01
Professor Zhang Zhuoli of the Department of Rheumatology and Immunology of Peking University First Hospital explained the changes of glucocorticoids in the treatment of rheumatoid arthritis, from the efficacy benefits of glucocorticoids, adverse reactions, stop reduction schemes to real events, and at the same time looked forward to the "poetry and distance" of hormone application, which provided great help for clinicians to use hormones more rationally in practice.
-
Hydroxychloroquine reduces neuroinflammation after traumatic brain injury
Time of Update: 2022-09-30
HCQ reduces neuroinflammation, activation and accumulation of microglia, and immune cell infiltration in the brain, reduces BBB destruction and cerebral edema, and upregulates the expression of tight connections.
-
How to manage patients with systemic lupus erythematosus before pregnancy
Time of Update: 2022-09-30
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that tends to occur in women of childbearing age, and pregnancy-related problems are extremely important for both maternal disease progression and fetal development.
-
Hydroxychloroquine is used to treat patients with systemic lupus erythematosus and their dosage
Time of Update: 2022-09-30
SLEDAI scores of patients with SLE who are treated with conventional or low-dose HCQ at baseline, 3-month follow-up, and 6-month follow-up:Methods: Disease activity was assessed using SELENA-SLEDAI 2011 standard, cutaneous lupus erythematosus disease area and severity index (CLASI), and serum biomarkers.
-
Int J Clin Pract: Hydroxychloroquine has potential clinically significant drug-drug interactions
Time of Update: 2022-09-30
Methods: Inhibitors, substrates, and inducer drug lists of interest for CYP enzymes from internationally recognized evidence-based drug interaction resources were used to identify potentially clinically significant pharmacokinetic DDI pairs of HCQ.
-
How does hydroxychloroquine play a role in the treatment of systemic lupus erythematosus?
Time of Update: 2022-09-30
Hydroxychloroquine (HCQ) is recommended according to European Rheumatology Union (EULAR) guidelines:Based on these multiple benefits, HCQ is now the mainstay long-term treatment for SLE, and current guidelines recommend HCQ for all patients unless there are contraindications or side effects.
-
Autoimmune diseases, increase the risk of cardiovascular disease! Lancet Journal Study 2.5 million people
Time of Update: 2022-09-30
8 times, respectively, in terms of specific diseases, and patients with systemic sclerosis, Addison disease, systemic lupus erythematosus and type 1 diabetes had the highest risk of cardiovascular disease, with an increase of 2.
-
Cell Reports Zhu Hao's team at Southern Medical University developed deepFavored, a deep learning algorithm that revealed that adaptive mutations are associated with disease susceptibility
Time of Update: 2022-09-30
Recently, the team of Professor Zhu Hao of Southern Medical University in China published a research article entitled "Uncovering the extensive trade-off between adaptive evolution and disease susceptibility" in the journal Cell Reports 。 The research team has developed a deep learning algorithm called DeepFavored, which can distinguish between favorable mutations and "free-rider" mutations by statistically testing existing genome-wide association study (GWAS) datasets.
-
Hydroxychloroquine can actually reduce EAU!
Time of Update: 2022-09-30
Hydroxychloroquine (HCQ) reduces inflammation caused by inflammation of retinal vascular endothelial cells (RVEC) dysfunction: Results: HCQ therapy protects mice from uveitis, which can be demonstrated by a decrease in the expression of inflammatory factors, chemokines, and adhesion molecules in the retina.
-
Lupus: Tytazeptide significantly increases SRI-4 response rates and reduces glucocorticoid doses in children with SLE in refractory children
Time of Update: 2022-09-30
1177/09612033221097812 Clinical data from a self-controlled trial of the safety and efficacy of a treatment of refractory children with systemic lupus erythematosus (cSLE) in a titazep, published in the journal Lupus.
-
Effect of hydroxychloroquine on ventricular repolarization: a randomized clinical trial
Time of Update: 2022-09-30
The results of this concentration effectivity ECG analysis show that hydroxychloroquine does not affect ventricular complexation, including the QTcF interval and T-wave morphology, at concentrations similar to those in patients with SARS-CoV-2.
-
Cell Blockbuster Review: Design of Therapeutic Antibodies
Time of Update: 2022-09-30
029： ， 。 Video Mini Program like, tap twice to cancel like in viewing, tap twice to cancel in viewing Antibody drugs are an important aspect of the biopharmaceutical field, and there are currently more than 100 antibody drugs approved by the US FDA for the treatment of a variety of human diseases.
-
Cell Sub-Journal: Simulated fasting can reshape the body's immunity and improve the effect of cancer immunotherapy
Time of Update: 2022-09-22
Compared with other experimental groups, fasting simulated diet combined with immunotherapy also increased the expression of cytotoxic activity-related genes and CD8 T cell activation percentage in tumor immune infiltration.
-
Sci Immuno iNKT cells help fight cancer
Time of Update: 2022-09-22
In 2022, the Giulia Casorati and Paolo Dellabona research group from Milan, Italy, presented a presentation in Science Immunology titled TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and The suppressive myeloid cells article provides an in-depth study of the anti-tumor effects and mechanisms of iNKT cells.
-
Gao Jinming/Fu Yangxin/Li Bo and others found that metabolizing "waste" lactic acid can enhance anti-tumor immunity
Time of Update: 2022-09-21
Thesis link: open reprint welcome to forward to the circle of friends and WeChat group SourceChina Biotechnology Reticulated Lactic Acid (Lactate), has always been considered to be a metabolic waste produced by carbohydrate fermentation or anaerobic glycolysis of skeletal muscle during exercise.
-
Why don't immune cells attack gut microbes? Nature reveals key clues!
Time of Update: 2022-09-21
In a new study published in Nature on September 8, Beijing time, a research team from Cornell University's Weill Cornell School of Medicine found that a class of congenital lymphocytes plays an important role in establishing tolerance to symbiotic microorganisms in the human gastrointestinal tract.
