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The pandemic of SARS-CoV-2 has been expanding since January 2020
.
Hydroxychloroquine was originally developed as an antimalarial drug during World War II and has been used for decades as an antimalarial drug and to treat connective tissue diseases, with little
reported report of heart death after hydroxychloroquine.
Methods: Twenty young (≤ 30 years) and 20 elderly (65-75 years) healthy male subjects were enrolled
.
Plasma hydroxychloroquine concentrations
in both age groups.
Results: There was no significant correlation between hydroxychloroquine concentration and ECG characteristics (including RR-, QRS- and QTcF intervals) (P = .
Taken together, this concentration effect analysis in healthy subjects provides insight into the effects of hydroxychloroquine on ventricular repolarization without confounding factors
due to illness or hospitalization.
References:
Eveleens Maarse BC, Graff C, Kanters JK, van Esdonk MJ, Kemme MJB, In 't Veld AE, Jansen MAA, Moerland M, Gal P.