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Int J Clin Pract: Hydroxychloroquine has potential clinically significant drug-drug interactions

 Last Update: 2022-09-30
 Source: Internet
 Author: User

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Hydroxychloroquine (HCQ) has been approved in many countries to treat patients with
coronavirus disease‐2019 (COVID‐19).

This predictive DDI is reasonable for COVID-19 patients taking HCQ because many people with COVID-19 have multiple comorbidities and are susceptible to multiple medications
.

Methods: Inhibitors, substrates, and inducer drug lists of interest for CYP enzymes from internationally recognized evidence-based drug interaction resources were used to identify potentially clinically significant pharmacokinetic DDI pairs of
HCQ.

Results: Of the 329 identified interactions, the clinically significant DDI expected to lead to HCQ, 45 (13.

List of 29 potentially clinically significant severe DDI to HCQ identified from the clinical table of strong inhibitors of the FDA and Flockhart CYP enzymes involving CYP3A4/5, CYP2C8, and CYP2D6 enzymes:

In summary, clinicians should consider all resources for checking for DDI of HCQ because of disagreements
regarding the recruitment of interacting drugs.

References: Biswas M, Roy DN.

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