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Clinical information, 1s reach
Clinical question: Observational studies have demonstrated an association between gout and high blood pressure, but are they causal?
Screenshot of the literature
。 A new Mendelian randomization (MR) model was used to detect a causal relationship between gout and susceptibility to hypertension by roughening exposure after removing SNPs associated with measuring confounders, using 4 gout-associated SNPs and 10 SNPs associated with hypertension, and vice versa
.
Inverse variance weighting (IVW) and polygenic risk score (PRS) methods were used to estimate effect size
.
MR analysis of coarse exposure was performed
with and without covariate adjustment.
▎Main findings:
Of the 88,347 participants, 3,253 (3.
68%) had gout and 11,948 (13.
52%) had hypertension [31.
9% men; Average age 51.
1 (SD, 11.
1) years].After adjusting for confounding factors measured, MR analysis of coarsened exposure found IVW [relative risk (RR) 1.
10; 95% CI 1.
03 to 1.
19; P = 0.
0077] and PRS method (RR 1.
10; 95% CI 1.
02-1.
19; P=0.
0092) showed that gout had a significant positive causal effect
on susceptibility to hypertension.The results of causality are the same
before and after when it comes to measuring confounders.
However, hypertensive susceptibility has no causal relationship
to gout.
▎Conclusion and outlook:
In this study, it was found that susceptibility to gout has a causal relationship with hypertension, but susceptibility to hypertension has no causal relationship
with gout.
Proper management of gout can reduce the risk of
high blood pressure.
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