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Nature sub-journal: Inhibition of RNA synthesis after radiotherapy promotes the death of tumor cells
Time of Update: 2022-11-04
"CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway RNA, the molecule of the origin of life, has been shown to be essential for repairing human genetic material and preventing mutations that can lead to cancer.
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"Silent killer" – COVID-19 has been shown to trigger inflammation in the brain
Time of Update: 2022-11-04
The University of Queensland research team was led by Professor Trent Woodruff and Dr Eduardo Albornoz Balmaceda from the University of Queensland's School of Biomedical Sciences and virologists from the School of Chemical and Molecular Biosciences.
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J Immunother Cancer Shanghai Institute of Materia Medica, found that PD-L1/TLR7 dual-targeted nanobody conjugate drugs can reshape the tumor immune microenvironment
Time of Update: 2022-11-04
gov/36253000/ PD-L1/TLR7 dual-targeted nanoantibody conjugates reshape the tumor immune microenvironment (Contributing department: Gong Likun Research Group) Tumor immunotherapy represented by immune checkpoint inhibitors has changed the pattern of cancer treatment, PD-1/PD-L1 blockade therapy has made breakthroughs in the treatment of a variety of tumors, but it has problems such as low response rate and drug resistance recurrence, and it is found that new PD treatment strategies to improve efficacy are urgent problems to be solved.
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The rheumatology team of Renji Hospital reveals the core immunological characteristics of patients with anti-MDA5 antibody-positive dermatomyositis, which provides new ideas for precise targeted therapy
Time of Update: 2022-11-04
Recently, the rheumatology team of Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine published a paper entitled "Single-cell profiling reveals distinct adaptive immune hallmarks in patients with MDA5+ dermatomyositis" online in the journal Nature Communications (impact factor IF: 17.
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The South China Botanical Garden has made new progress in the study of the influence of functional traits on the life history of plants in the tropical monsoon evergreen broad-leaved forest in South Asia
Time of Update: 2022-11-04
Functional traits are the core plant attributes of plants to respond and adapt to environmental changes, and are an important research tool for predicting ecosystem response and adaptation to global
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Chromosome level genomic release of capers (mouse melon).
Time of Update: 2022-11-04
TRS_Editor A{margin-top:0px;margin-bottom:15px;line-height:2;font-family:;font-size:12pt;}Capparis spinosa is a perennial vine semi-shrub, a Capparidaceae plant of the genus Capparis, which originated in the arid regions of West or Central Asia and is mainly distributed in Xinjiang, Tibet, Gansu and other places in China.
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Xiamen University scholar Nature published a paper: METTL3 acetylation modification regulates its nucleoplasmic dynamic transposition and affects the mechanism of breast cancer metastasis
Time of Update: 2022-11-04
Original link: style="text-indent: 2em;">(Photo/Text You Han Research Group) The methyltransferase METTL3 (methyltransferase like 3) is responsible for the N6-adenosine methyl modification (m6A) of mRNA, which regulates gene expression and protein translation through a variety of mechanisms, and is widely involved in regulating cell life activities and the occurrence and development of a variety of diseases.
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For the first time, the underlying cause of chronic heart failure after a heart attack has been identified
Time of Update: 2022-11-04
essayIntramyocardial hemorrhage drives fatty degeneration of infarcted myocardium A multi-institutional study led by Dr. Rohan Dharmakumar of Indiana University School of Medicine found that iron drives the formation of adipose tissue in the heart, leading to chronic heart failure in about 50 percent of heart attack survivors.
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Cancers: Makes glioblastoma easier to treat
Time of Update: 2022-11-04
Now that Daddacha and his colleagues have published a report in the journal Cancer they have surprisingly found that both SAMHD1 and the essential DNA building block dNTP it can destroy are highly expressed in glioblastoma in humans, suggesting that SAMHD1 may be important for the aggressiveness of brain tumors and raises questions about what it does there.
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Wang Jian of the School of Physics and his collaborators observed quasi-bound states with discrete scale invariance at atomic defects of topological materials
Time of Update: 2022-11-04
Professor Wang Jian and Academician Xie Xincheng of the Center for Quantum Materials Science, School of Physics, Peking University, Professor Pan Minghu, School of Physics and Information Technology,
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A predictive method can better identify which species are vulnerable
Time of Update: 2022-11-04
" "Under non-equilibrium abundance fluctuations, the effects of these interactions change over time, affecting any given species' sensitivity to perturbations.
" "Under non-equilibrium abundance fluctuations, the effects of these interactions change over time, affecting any given species' sensitivity to perturbations.
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Biological explanation for the increased risk of cancer in dense breasts
Time of Update: 2022-11-04
Dense breasts that appear white on mammograms have a higher risk of breast cancer than non-dense breasts that appear gray.
Dense breasts that appear white on mammograms have a higher risk of breast cancer than non-dense breasts that appear gray.
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Singaporean scientists have cracked the genome of Singapore's national flower
Time of Update: 2022-11-04
Image source: SingHealthA*STAR's Singapore Genome Institute (GIS) and the Institute of Biodiversity Medicine (BD-MED) of Singapore Health Duke-National University of Singapore have deciphered the entire genetic blueprint of Singapore's national flower: the orchid (Papilionanthe Miss Joaquim, also known as Vanda Miss Joaquim, VMJ).
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The cause of shingles can cause stroke is exosomes
Time of Update: 2022-11-04
Dr Andrew Bubak, lead author of the study and assistant research professor in the Department of Neurology at the University of Colorado School of Medicine, said: "Most people know that shingles produces a painful rash, but they may not know that the risk of stroke is increased one year after infection.
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"Cell" was first proposed 30 years ago, and the answer is still available
Time of Update: 2022-11-04
WNK kinases sense molecular crowding and rescue cell volume via phase separation Scientists at the University of Pittsburgh and Carnegie Mellon University have solved a decades-long mystery about how cells control their size.
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Research has revealed how natural compounds kill major drug-resistant bacteria
Time of Update: 2022-11-04
" Scientists analyzed the effects of an organic compound on drug-resistant bacteria and discovered how it inhibits and kills a bacterium that causes serious illness and in some cases death.
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Cell Rep: How the rate of RNA editing in the brain increases as an individual ages
Time of Update: 2022-11-04
Mount Sinai researchers have cataloged thousands of brain sites where RNA has been modified over a human lifetime, a process known as adenosine to inosine (A-to-I) editing, providing important new avenues for understanding the cellular and molecular mechanisms of brain development and how they affect health and disease.
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The use of DNA biomarkers to detect early HPV-positive oropharyngeal cancer has limitations
Time of Update: 2022-11-04
"Association of Pretreatment Circulating Tumor Tissue–Modified Viral HPV DNA With Clinicopathologic Factors in HPV-Positive Oropharyngeal Cancer Oropharyngeal cancer caused by human papillomavirus (HPV) has risen sharply in recent years, replacing tobacco use and alcohol abuse as the main drivers of new cases.
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Rare human intestinal diseases are due to a decrease in protein synthesis
Time of Update: 2022-11-04
Particularly affected are genes in the mTOR signaling pathway, which is a central regulator of protein synthesis; After treatment with mTOR inhibitors in wild zebrafish, intestinal developmental defects developed in the Mycn mutant.
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The Institute of Zoology collaborated to establish a cell lineage landscape database
Time of Update: 2022-11-04
The convergence and fusion of gene expression changes under different conditions were realizedThe Lineage Landscape database realizes the collection and integration of multidimensional omics data at different levels and at different times of cell lineage.
