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The first large-scale bipolar disorder gene study in Asian populations was launched
Time of Update: 2022-11-04
"There hasn't been any large-scale genetic studies of bipolar disorder in Asian populations," said Hailiang Huang, director of the Stanley Global Asia Program at Broad University's Stanley Center for Psychiatric Research, who is also an assistant professor at Massachusetts General Hospital and Harvard Medical School.
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Nature Chemical Biology: Mechanism of action of TRPV3 ion channel protein inhibitors and potential for the treatment of a variety of skin diseases
Time of Update: 2022-11-04
Trpvicin has shown good therapeutic effect in mouse models To further investigate the mechanism by which Trpvicin functions, the authors used cryo-EM to resolve the high-resolution structure of the human-derived TRPV3-Trpvicin complex, revealing that Trpvicin binds to a reported TRPV In the pockets of ligand sites, Trpvicin was found to exert inhibition by stabilizing TRPV3 in the off state.
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Nature: Why do you just want to lie down when you're sick?
Time of Update: 2022-11-04
By stimulating an immune response in mice, the researchers demonstrated that specific cell populations in the brainstem could effectively induce three suggestive uncomfortable behaviors.
By stimulating an immune response in mice, the researchers demonstrated that specific cell populations in the brainstem could effectively induce three suggestive uncomfortable behaviors.
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The world's first six-gene edited pig-monkey multi-organ and multi-tissue combined transplantation
Time of Update: 2022-11-04
On October 25, Xijing Hospital of Air Force Military Medical University announced that led by Professor Dou Kefeng, academician of the Chinese Academy of Sciences and 20 disciplines including hepatobiliary surgery, urology, cardiovascular surgery and other disciplines, the world's first six-gene edited pig-monkey multi-organ and multi-tissue joint transplantation was successful, achieving a breakthrough in the international xenotransplantation field of multi-organ and multi-tissue transplantation.
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Further development of using CRISPR to edit T cells to treat drug-resistant leukemia
Time of Update: 2022-11-04
Researchers at Great Ormond Street Hospital for Children (GOSH) and University College London's Great Ormond Street Institute for Child Health (UCL GOS ICH) used CRISPR/Cas9 technology to engineer donor T cells in an attempt to treat critically ill children with drug-resistant leukaemia who would otherwise have exhausted all available treatments.
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Inhibits SFRP4 to downregulate the aging-related secretory phenotype, helping to prevent skin aging
Time of Update: 2022-11-04
204273 essayDown-regulation of aging-related secretory phenotypes by inhibiting the secretion of curl-associated protein 4 helps prevent skin aging Figure: Effects of SFRP4 knockout on skin in aging mice.
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The latest article published in the Cell sub-journal of East China University of Science and Technology: a new technology for high-performance lactic acid monitoring and imaging
Time of Update: 2022-11-04
On October 28, Professor Zhao Yuzheng and Professor Yang Yi, School of Pharmacy, East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Shanghai Frontier Sci
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Gut bacteria may be a potential therapeutic target for rheumatoid arthritis
Time of Update: 2022-11-04
"The next step for us to do is to determine whether these bacteria are associated with other genes, the environment and mucosal immune responses in larger populations at risk of rheumatoid arthritis, and ultimately determine the development of rheumatoid arthritis," Kuhn said.
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Rare endocannabinoid gene mutations cause neurological disorders
Time of Update: 2022-11-04
In a study published in the October 2022 issue of the journal Brain, researchers from the Rady Children's Institute for Genomic Medicine and the University of California San Diego School of Medicine describe a new clinical syndrome they have discovered, Neuro-Ocular DAGLA-related Syndrome (NODRS), in children whose diaacylglycerol lipase α (DAGLA) gene terminates mutations, This gene encodes an enzyme in the brain involved in the signaling pathway of the endocannabinoid (eCB) system.
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The Wang Lan research group of the Institute of Nutrition and Health collaborated to reveal a new mechanism by which UHRF1 regulates acute myeloid leukemia
Time of Update: 2022-11-04
On October 27, 2022, the international academic journal Cell Research published online the latest research results entitled "Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication i
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Nature Communications—Zhang Xiaoming's research group uses single-cell technology to reveal core immunological characteristics and treatment of highly lethal MDA5 antibody-positive dermatomyositis...
Time of Update: 2022-11-04
Zhang Xiaoming's research group and Renji Rheumatology clinical team carried out a series of key research on MDA5+ DM, a refractory disease, using high-dimensional flow cytometry technology to measure peripheral immune cells in the early stage, dividing MDA5+ DM patients into high-risk and low-risk groups, and finding that CD8+ T cells have a high degree of activation, and the relevant paper was published in the authoritative journal of rheumatology Arthritis & Rheumatology (2022, 74:1822).
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The Institute of Aquatic Sciences and others revealed the distribution and influence of intestinal antibiotic resistance genes in the main culture area of Protocrayus cruzi in China
Time of Update: 2022-11-04
Habitat, environmental factors (NO3-N, pH and water temperature) and microbial α diversity all have significant influences on ARGs. The conditioned pathogens Streptococcus, Aeromonas and Acinetobacter There is a significant positive correlation with high-risk ARGs, indicating that these conditional pathogens may be potential hosts of high-risk ARGs, which may lead to ineffective antibiotic treatment in aquaculture, so susceptibility tests on pathogenic microorganisms are required to guide rational drug use.
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iScience: A new method can determine which genes are associated with the aging process
Time of Update: 2022-11-04
elegans Lifespan Mutants by Screening for Early-Onset Protein Aggregation Researchers from North Carolina State University have developed a new method to determine which genes are associated with the aging process.
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Science: Spermidine has antitumor effects in aging mice
Time of Update: 2022-11-04
Bioenergetically, compared with young CD8, mitochondrial activity of senescent CD8+ T cells is impaired, oxygen consumption rate, ATP production and fatty acid oxidation activity are reduced。 We found that SPD supplementation enhanced the antitumor activity of PD-1 blocking immunotherapy in older mice.
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Chinese scholars have made progress in imaging the charge separation and transport process of photocatalyst particles at the full spatiotemporal scale
Time of Update: 2022-11-04
Figure Full-time space-space dynamic "image" of the process of photogenerated charge separation of a single photocatalytic particle from femtoseconds to secondsWith the support of the National Natural Science Foundation of China (Grant No.
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Fan Xiaohui's research group at the School of Pharmacy of Zhejiang University reported in Nature Communications that the first ...
Time of Update: 2022-11-04
In recent years, single-cell sequencing (scRNA-seq) and spatial transcriptome sequencing (Spatially resolved transcriptomics) technologies have revolutionized the way people understand complex tissue
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Chemical Society Reviews cover review Lu Boxun / Ding Lu / Fei Yiyan / Xing Dong co-published a review of new technologies for degradation of lysosomal pathways represented by ATTEC and other technologies
Time of Update: 2022-11-04
Chemical Society Reviews cover roundupLu Boxun / Ding Lu / Fei Yiyan / Xing Dong collaborated to publish a review of new degradation technologies targeting lysosomal pathways represented by ATTEC and
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Synthetic biologists at Westlake University have tackled a world-class challenge
Time of Update: 2022-11-04
Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs All life exists in a mirror.
Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs All life exists in a mirror.
Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs All life exists in a mirror.
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Lu Guanda's team's new article: Synthetic gene control system for precise control of mammalian cells
Time of Update: 2022-11-04
Nature Communications, 2022; 13 (1) Using a CRISPR protein-based approach, MIT researchers have developed a new method that can precisely control the amount of a particular protein produced in mammalian cells.
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Physical activity in the afternoon or evening is associated with reduced insulin resistance.
Time of Update: 2022-11-04
A new study published in Diabetologia, a journal of the European Association for the Study of Diabetes, found that physical activity in the afternoon or evening was associated with reduced insulin resistance (and thus better control of blood sugar) compared to physical activity evenly distributed during the day.
