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The study identified potential new therapeutic targets for sleep apnea
Time of Update: 2022-11-04
1113/JP283678 In a new study of obese mice, researchers at the Johns Hopkins School of Medicine say they have added new evidence that special channel proteins may be therapeutic targets for sleep apnea and similar abnormally slow breathing disorders in obese people.
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The research team of the Institute of Microbiology revealed the molecular and cellular mechanism by which the kinesin nKCBP regulates symbiosis in rhizobia
Time of Update: 2022-11-04
On November 1, 2022, the Kong Zhaosheng research group of the Institute of Microbiology published a publication in Nature Plants entitled " A Legume Kinesin Controls Vacuole Morphogenesis for Rhizobi
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Chromosome level genomic release of capers (mouse melon).
Time of Update: 2022-11-04
TRS_Editor A{margin-top:0px;margin-bottom:15px;line-height:2;font-family:;font-size:12pt;}Capparis spinosa is a perennial vine semi-shrub, a Capparidaceae plant of the genus Capparis, which originated in the arid regions of West or Central Asia and is mainly distributed in Xinjiang, Tibet, Gansu and other places in China.
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In aging brains, there are fewer anti-inflammatory molecules
Time of Update: 2022-11-04
"A class of anti-inflammatory lipids decrease with aging in the central nervous The brain is made up of lipids, but the role of these molecules in health and disease remains unknown.
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The new indication of class I new drug CS0159 was approved in China IND
Time of Update: 2022-11-04
CS0159 new indication IND approved in China Xu Huaqiang's team at Shanghai Institute of Materia Medica, has been in-depth research in the field of the mechanism of action of nuclear hormone receptor drugs for more than 20 years; Li Jia's team has long been committed to the research and development of innovative drugs for metabolic diseases, and has established a multi-target integration, multi-functional screening and multi-level pharmacodynamic evaluation system around metabolic diseases such as diabetes and non-alcoholic steatohepatitis.
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For the first time, the underlying cause of chronic heart failure after a heart attack has been identified
Time of Update: 2022-11-04
essayIntramyocardial hemorrhage drives fatty degeneration of infarcted myocardium A multi-institutional study led by Dr. Rohan Dharmakumar of Indiana University School of Medicine found that iron drives the formation of adipose tissue in the heart, leading to chronic heart failure in about 50 percent of heart attack survivors.
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The application of single-cell transcriptome technology by Cui Jie team at eBioMedicine highlighted the potential function of human endogenous retroviruses in gallbladder cancer
Time of Update: 2022-11-04
On October 28, Lancet's international journal eBioMedicine published online the latest research results of Cui Jie's research group at the Shanghai Pasteur Institute of the Chinese Academy of Science
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Cell subjournal: How gut bacteria affect the role of cocaine in mice
Time of Update: 2022-11-04
Senior author Vanessa Sperandio, a microbiologist and senior author at the University of Wisconsin School of Medicine and Public Health, said: "Gut bacteria are consuming all of glycine, and levels of glycine in the system and brain are declining.
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NEJM: Monoclonal antibodies prevent malaria infection in African adults
Time of Update: 2022-11-04
A clinical trial by the National Institutes of Health found that a dose of antibody drugs could safely protect healthy non-pregnant women from malaria infection during the six-month malaria peak season in Mali, Africa.
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"Smart" red blood cells to deliver antibiotics against specific bacteria
Time of Update: 2022-11-04
Erythro-PmBs: A Selective Polymyxin B Delivery System Using Antibody-Conjugated Hybrid Erythrocyte Liposomes Scientists test "smart" red blood cells to deliver antibiotics that target specific bacteria"Many traditional drug therapies have challenges.
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Xiamen University scholar Nature published a paper: METTL3 acetylation modification regulates its nucleoplasmic dynamic transposition and affects the mechanism of breast cancer metastasis
Time of Update: 2022-11-04
Original link: style="text-indent: 2em;">(Photo/Text You Han Research Group) The methyltransferase METTL3 (methyltransferase like 3) is responsible for the N6-adenosine methyl modification (m6A) of mRNA, which regulates gene expression and protein translation through a variety of mechanisms, and is widely involved in regulating cell life activities and the occurrence and development of a variety of diseases.
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Genome sequencing of honey crispy apples promises to breed better apples
Time of Update: 2022-11-04
Advances in gene sequencing technology have made it possible to sequence, assemble, and publish the honey crispy apple genome in a fraction of the time.
Advances in gene sequencing technology have made it possible to sequence, assemble, and publish the honey crispy apple genome in a fraction of the time.
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Nature Chemistry: A new approach to the study of ribosome function
Time of Update: 2022-11-04
Article Insights into the ribosome function from the structures of non-arrested ribosome–nascent chain complexes Figure: Illustrates the principle of the natural chemical ligation method developed by Syroegin et al.
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Small Methods Cholesterol metabolism regulates nanoparticles to improve tumor photodynamic-immunotherapy effect
Time of Update: 2022-11-04
Photodynamic therapy (PDT)-mediated immune activation makes it both effective as tumor immunotherapy. However, the efficacy of PDT immunity is affected by the function and status of tumor-infiltratin
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The rheumatology team of Renji Hospital reveals the core immunological characteristics of patients with anti-MDA5 antibody-positive dermatomyositis, which provides new ideas for precise targeted therapy
Time of Update: 2022-11-04
Recently, the rheumatology team of Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine published a paper entitled "Single-cell profiling reveals distinct adaptive immune hallmarks in patients with MDA5+ dermatomyositis" online in the journal Nature Communications (impact factor IF: 17.
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J Immunother Cancer Shanghai Institute of Materia Medica, found that PD-L1/TLR7 dual-targeted nanobody conjugate drugs can reshape the tumor immune microenvironment
Time of Update: 2022-11-04
gov/36253000/ PD-L1/TLR7 dual-targeted nanoantibody conjugates reshape the tumor immune microenvironment (Contributing department: Gong Likun Research Group) Tumor immunotherapy represented by immune checkpoint inhibitors has changed the pattern of cancer treatment, PD-1/PD-L1 blockade therapy has made breakthroughs in the treatment of a variety of tumors, but it has problems such as low response rate and drug resistance recurrence, and it is found that new PD treatment strategies to improve efficacy are urgent problems to be solved.
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ATR-mediated DNA damage response underlies abnormal B cell activity in systemic lupus erythematosus
Time of Update: 2022-11-04
，IFN-αBATR（CD40、CD80BAFF）[-DR（HLA-DR）](4，AC，S11、AB）。ATR，IFN-αBHLA-DR，ATR（S12）。，ATRChk1，ATR-Chk1CHR-124（Chk1Chk1i）（S12CS13）。，ATRIFN-αB，ATRB。4ATRiIFN-αB。B cells are isolated from the peripheral blood of healthy people by magnetic bead method and cultured for 2 (D2), 3 (D3), and 7 (D7) days with IL-21/CpGb/sCD40L survival and mild proliferation mixed culture medium in the presence or absence of IFN-α (850 U/ml) and ATRi or DMSO (control), depending on the experiment.
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Global warming increases the risk of heat exhaustion in ectothermic animals
Time of Update: 2022-11-04
Although the researchers are not aware of the underlying physiological and biochemical responses that lead to heat stress and death, their study shows that these processes are extremely sensitive to temperature in all ectothermic animal populations.
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Effect of "new and old" actin on cell motility
Time of Update: 2022-11-04
A new study in the journal Nature provides a high-resolution structure showing how two key biochemical states of actin work with bending forces to determine how actin interacts with other proteins.
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The South China Botanical Garden has made new progress in the study of the influence of functional traits on the life history of plants in the tropical monsoon evergreen broad-leaved forest in South Asia
Time of Update: 2022-11-04
Functional traits are the core plant attributes of plants to respond and adapt to environmental changes, and are an important research tool for predicting ecosystem response and adaptation to global
